The drug "Sidnofarm" - instructions for use. Tablets "Sidnofarm": analogues and reviews

The drug "Sidnofarm" is an active peripheral agent that is able to expand the lumens of blood vessels and reduce the pressure in them. Also, the drug helps prevent and stop angina attacks, is used to treat other symptoms of coronary insufficiency.

Principle of action of the drug

Sidnofarm is a donator of nitric oxide, released with the help of the drug in the course of metabolic reactions. This binary compound stimulates the production of Soluble guanylate cyclase, an increased concentration of which leads to relaxation of smooth muscle tissue in the vessels. As a result, the load on their walls decreases, and as a result, the balance between the oxygen demand and its entry into the blood is restored. The narrowed vessels that are capable of stretching expand under the influence of the medication Sidnofarm.

Also, the drug slows the release and synthesis of thromboxane and serotonin, which leads to suppression of the early phase of aggregation of these enzymes and prevention of clotting.

pharmachologic effect

How does the drug "Sidnofarm" act biologically on the human body? Instruction for use says that as a result of the application of this agent in the side (bypass) blood flow pathways, blood circulation improves. Also, the drug increases the tolerability of the load and reduces the frequency of attacks of angina arising from physical efforts.

Among other things, the drug "Sidnofarm" narrows the heart chambers in the case of heart failure in chronic form, lowers the pressure in the arteries of the lungs. Due to this effect, the left ventricle of the main human organ is less filled with blood, and the muscle strain of the myocardium decreases.

Duration of action of the drug

How quickly does the patient improve when he takes Sidnofarm? Feedback from numerous patients and instructions for use suggest that it is well and quickly absorbed by the digestive system. The action of the medication "Sidnofarm" can be noticed after 20 minutes from the moment of its use inside or in 5-10 minutes, if you put the tablet under the tongue. The peak reaction of the body to the drug is observed between 30 and 60 minutes after its administration. Effective for 6 hours.

Medication "Sidnofarm" practically does not bind to plasma proteins. The process of metabolism of the drug occurs in the liver, and it is derived mainly through the kidneys. In the case of prolonged therapy with this drug, resistance to it does not arise.

Sidnofarm tablets: indications for use

The drug is used in medicine in the following cases:

1. To stop and prevent attacks of angina pectoris.

2. With myocardial infarction at the stage of stabilization of hemodynamic parameters.

3. If the left ventricle of the heart is in acute form.

4. With increased blood pressure in the pulmonary lobe.

5. With heart failure in chronic form.

In the latter case, there is one feature of the use of the drug "Sidnofarm". Indications for its use in this situation are diseases in which it is necessary to take more glycosides and diuretics in combination with the drug presented.

Mode of application

To avoid complications and overdose, only the doctor should prescribe Sidnofarm. Indications for use of this drug determine its use inside during or after a meal. Drink tablets with water in sufficient quantities.

In order to prevent attacks of angina, Sidnofarm is prescribed 1-2 mg for taking 4 to 6 times during the first and second day of treatment, 2-4 mg for 2-3 times every other day. Sometimes the dose rises to 6-8 mg or more, but the maximum is 12 mg.

The drug is dosed individually in each case. Its required amount for therapy depends on the stage and type of the disease, as well as on the symptomatology. Depending on the course of the disease, the duration of the course of treatment is also prescribed.

Side effects

Does the use of Sidnofarm tablets have a negative effect? Instruction for the use of the drug informs that the drug is capable of provoking the onset of a headache at the initial stage of its administration. After a short period of time, the sensation disappears.

Also, when using the drug "Sidnofarm" it is possible to lower blood pressure, sometimes to a state of collapse. Occasionally there is a slowdown in motor and mental reactions. This feature of the drug when it is used should be taken into account by drivers of vehicles and people of other professions that require concentration of attention and making quick decisions in the workplace.

Among other things, due to the use of tablets "Sidnofarm" (reviews of patients confirm the data), there may be side effects such as nausea, itching, dizziness, skin rashes and other allergic reactions.

Contraindications

Pathologies, in which the use of the drug "Sidnofarm" is contraindicated:

• Acute stage of myocardial infarction;
• Glaucoma (especially closed-angle);
• Craniocerebral, arterial hypertension;
• Collapse of blood vessels;
• Disorders of the blood circulation of the brain;
• Pregnancy (first trimester) and lactation;
• Advanced age ;
• Individual intolerance of the drug.

Interaction with other drugs

Is it permissible in therapy to use tablets with other medicines Sidnofarm? Instruction for the use of the drug says that the drug can simultaneously be used with calcium antagonists and beta-adrenoceptor blockers.

When using the medication "Sidnofarm" for medicinal purposes, it is necessary to completely exclude the ingress of alcohol into the body.

Features of the drug

In what cases should you use the medicine "Sidnofarm" with extreme caution? The instruction for its use explains that it is necessary to beware of unforeseen reactions of the body to the drug in case of impaired blood circulation of the brain, with increased intracranial pressure, with arterial hypotension, glaucoma, and also after hemorrhagic stroke or after myocardial infarction.

Patients in old age in the presence of deficiency of the kidneys or liver should use a minimal amount of the tablet "Sidnofarm". Instructions for use of the drug also warns that the dye E110, which is contained in this drug, can cause reactions of an allergic nature.

During pregnancy, it is necessary to carefully analyze the risk-to-fetus ratio and benefits for the expectant mother before starting treatment with Sidnofarm. Categorically contraindicated use of the drug during lactation. If the use of a medicine is vital at this time, then breastfeeding should be stopped. Children and adolescents under the age of 18 are also prohibited from taking this medication.

Overdose

What consequences can occur when Sidnofarm tablets are consumed in excessive amounts? First of all, it is fraught with a sharp drop in blood pressure. This causes dizziness, nausea, vomiting.

Treatment for an overdose depends on the symptomatology. An indispensable condition is the measures aimed at the speedy cleansing of the body of the drug "Sidnofarm", - forced diuresis or gastric lavage.

Form of issue

The drug "Sidnofarm" is produced in the form of tablets of 4 mg or 2 mg, as well as in the form of pills of prolonged action of 8 mg. The drug is packaged in contoured cellular plates. Each of them contains 10 tablets. The plates are packed in boxes, consisting of cardboard, 3 pieces (in one package contains 30 pills).

Storage conditions

Tablets "Sidnofarm" refer to potent medicines. Keep them for up to three years in cool, dry places out of the reach of children, at a temperature of 15 to 25 ° C.

Composition

The main active substance of the drug "Sidnofarm" is molsidomine. The auxiliary components of the drug include Avicel PH 101, mint oil, starch, hydroxypropylmethylcellulose, lactose, magnesium stearate, aerosil 200, mannitol.

Analogues

Can I replace Sidnofarm tablets with other medications? Analogs of this drug exist. These include "Dilasidom", "Corvamin" and "Corvaton" medications. The characteristics of each of them are given below.

The drug "Dilasidom" ("Dilasidom") . Produced in Poland. Its active substance is, as in the Sidnofarm facility, molsidomine (molsidomine). According to anatomo-therapeutically-chemical (ATC) classification, "Dilasidom" refers to peripheral vasodilators used for the therapy of heart diseases and antianginal drugs.

Means "Corvamin" ("Corvamin"). Produced in the Netherlands. The active ingredient of the drug is also molsidomine. According to the ATC classification, the drug "Corvamin" refers to antianginal drugs and peripheral vasodilators, which are used in the treatment of heart disease.

Medication "Corvaton" ("Corvaton"). Produced in Germany. Actively acting, the main substance of this drug is, as well as other analogues of tablets "Sidnofarm", molsidomine. According to the ATC classification, the drug "Corvaton" is a group of antianginal drugs and peripheral vasodilators, which are used to treat heart ailments.

Under no circumstances should you use Sidnofarm tablets or their analogues without the appointment of a doctor. Self-medication can lead to irreversible negative consequences. Also, it is strictly forbidden to change the dosage and duration of therapy, according to your own feelings, without consulting the doctor.