Method and instruction for the application of "Loraxon". Analogues and reviews

What is a drug such as "Loraxon 500"? The instructions for use, the characteristics of this product, as well as its indications, form, analogs and composition will be described below.

Packaging, form, composition of medicament

What form is typical for the drug in question? What does the instruction for use tell us about this? "Loraxon" is a crystalline powder of white or slightly yellowish color, intended for the preparation of intramuscular or intravenous solution. This medication contains an active ingredient, such as ceftriaxone. It is in the form of sodium salt.

Also, the drug "Loraxon", the instruction for which is contained in a pack of cardboard, includes a solvent in the form of water for injection.

The product in question is produced in glass bottles of 10 ml, which are placed in paper boxes (can be sold together with or without solvent).

Pharmacology of medicament

What is the aforementioned drug? What information does the instruction manual contain? "Loraxon" is an antibiotic (cephalosporin) of the third generation, intended for parenteral administration. It has a bactericidal action.

Due to the ability to inhibit the synthesis of cell membranes, this drug inhibits the growth of most gram-negative and gram-positive microorganisms.

According to experts, ceftriaxone is particularly resistant to beta-lactamases (penicillinase, cephalosporinase), which are produced by most bacteria.

Kinetic features of the drug

How is the drug being distributed over the human body? What does the attached instruction for use say about this? "Loraxon" with parenteral administration penetrates well into almost all tissues and liquids.

With intravenous infusion, ceftriaxone diffuses into the interstitial fluid rather quickly, where its bactericidal properties persist throughout the day.

It should also be noted that the active component of this agent reversibly binds to albumin. Due to the small amount of the latter in the interstitial fluid, the concentration of the drug in it is slightly higher than in the blood serum.

In what time frame is this medication removed from the patient's body? What does the instruction for use say? "Loraxon", the composition of which was discussed above, is displayed within 8 hours (along with bile and urine). It should also be noted that under the influence of intestinal flora, the active element of this agent is converted into an inactive metabolite.

In newborns, the half-life of the drug in question is 8 days, and in elderly people (over 70 years) this period is 2 times greater.

Kinetics of the drug in special cases

With failures in the kidney system, as well as liver pathologies in adults, the pharmacokinetics of ceftriaxone remains virtually unchanged, and the elimination half-life is not significant.

If the kidney function is significantly impaired, then the drug is excreted mainly along with the bile, and if the liver is damaged, ceftriaxone is excreted mainly through the kidneys.

In newborn infants and toddlers with inflammation of the meninges, this medication can penetrate into the cerebrospinal fluid. In adults with meningitis, 5-25 hours after the administration of ceftriaxone at a dosage of 50 mg / kg body weight, its concentration is many times greater than the MIC that is required to suppress the bacteria that cause the disease.

Indications

When should I inject with Loraxon 500? Instructions for use (injections should be prescribed only by an experienced doctor) argues that this medication is intended for the treatment of infectious and inflammatory diseases caused by drug-sensitive bacteria. Thus, it is actively used when:

• Meningitis;
• Infections of the ENT organs;
• Sepsis;
• Infections of the urinary tract and kidneys;
• Infections in the reproductive system (including gonorrhea);
• Infections in the abdominal cavity (including inflammatory diseases of the digestive tract, peritonitis, diseases of the bile ducts);
• Infections of the skin;
• Infections of the respiratory tract (including pneumonia);
• Infections of joints and bone tissue;
• Infections in people with low immunity.

Also, the agent in question can be shown for the prevention of infectious lesions in the postoperative period.

Prohibitions for appointment

Are there any contraindications to the above medication? What does the attached instruction for use say about this? "Loraxon," whose testimony was listed above, can not be assigned in the following cases:

• With increased sensitivity of the patient to penicillins and cephalosporins;
• In the first trimester of pregnancy.

With caution this medication is recommended to people with hepatic insufficiency, colitis and enteritis. It is also necessary to exercise caution in NNC, hyperbilirubinemia in newborn babies, in the last two trimesters of pregnancy, in premature infants and in breastfeeding.

Instructions for use

"Loraxon" is administered to patients intravenously or intramuscularly. The average daily dosage of this drug for adults and children from 12 years is 1-2 g once a day (every 24 hours).

In especially severe cases, as well as in infections that have been caused by moderately sensitive pathogens, the daily dose of this remedy can be increased to 4 g.

The following dosage is recommended for newly-born children when the medication is administered once a day: 20-50 mg / kg (before 2 weeks of age).

For infants and children up to 12 years of age, the dose of the drug per day should be 20-75 mg / kg. Adolescents with a body weight of 50 kg of medication prescribed in adult dosages.

The duration of treatment with this drug depends on the course of the disease.

Rules for the preparation of solutions

How correctly to prepare a medicinal solution? What does the instruction for use tell us about this? "Loraxon", the release form of which was presented above, for intramuscular administration should be diluted (in the amount of 1 g) in 3.5 ml of a 1% solution of lidocaine, and then injected deeply into the gluteal muscle.

To prepare the drug for intravenous injection, 1 g of powder should be diluted in 10 ml of distilled water (sterile). Ready solution should be slowly inserted into the vein (for 4 minutes).

For intravenous infusion, 2 g of the drug should be diluted in 40 ml of a solution (for example, sodium chloride, dextrose or fructose), free of calcium. Such an infusion should be conducted for at least half an hour.

Side effects

Does the drug Loraxon cause adverse reactions? Instructions for use (injections must be done only in a hospital) states that against the background of using this medication the patient can develop:

• Nausea, leukopenia, vomiting, granulocytopenia, diarrhea, hypocoagulation, constipation, hemolytic anemia, flatulence, lymphopenia;
• Abdominal pain, phlebitis, taste disorder, tenderness along the vein, stomatitis, urticaria, glossitis, neutropenia;
• Pseudomembranous enterocolitis, infiltration and soreness at the site of intramuscular injection, disruption of liver function;
• Renal dysfunction, dysbacteriosis, thrombocytosis, glucosuria, thrombocytopenia, oliguria, rash, azotemia, bronchospasm;
• An increase in urea in the blood, eosinophilia, hypercreatininaemia, exudative erythema polymorph, cylindruria, nasal bleeding, hematuria, superinfection, anuria;
• Chills, serum sickness, fever, angioedema, itching, dizziness, anaphylactic shock, candidiasis, headache.

Interaction and cases of overdose

An overdose of the drug under consideration is manifested by dizziness, headache, paresthesia, convulsions, encephalopathy and coma. To eliminate such phenomena, symptomatic treatment is used, as well as supporting the vital functions of the body.

Simultaneous reception of ceftriaxone with aminoglycosides increases their antibacterial activity. To prevent toxic effects, these agents are administered at different times and places.

With the parallel use of "Loraxon", inhibitors of platelet aggregation and NSAIDs, there is a high risk of bleeding.

When taken with "loop" diuretics there is a great danger of nephrotoxicity.

The drug in question is incompatible with ethanol, since such a combination causes severe nausea, epigastric spasms, vomiting, redness of the face, decreased blood pressure and tachycardia.

It is strictly forbidden to recruit ceftriaxone and other antibiotics into one syringe.

Similar drugs and reviews about the drug

Now you know what "Loraxon" is. Instructions for use, analogues of the means are discussed in this article.

How can I replace this medication? Experts consider the following products to be similar drugs: "Ceftriaxone-Promed", "Ceftriaxone-Elf", "Cefogram", "Cephson", "Ceftriaxone-Protech", "Ceftriaxone-Jodas", "Ceftriabol", "Cephathrin".

According to the patients' reviews, they were most often used to treat ENT infections and respiratory tract infections. Analyzing their reports, we can safely conclude that its rapid operation and high efficiency. It should also be noted that with the use of this medication, some patients experienced minor adverse reactions that did not require the withdrawal of therapy.