Antibiotic "Ceftriaxone". Description

The antibiotic "Ceftriaxone" (analogues of the preparation "Betasporin", "Roceferin", "Lifaxon") belongs to the category of cephalosporin semisynthetic drugs. Medication refers to third generation drugs.

The antibiotic "Ceftriaxone" has a high resistance to beta-lactamases. The drug is able to maintain high concentrations throughout the day. This, in turn, facilitates outpatient treatment of patients. It is established that the drug is safe, including for newborn patients, and for people at risk.

The antibiotic "Ceftriaxone" is produced in the form of a powder intended for the preparation of an injection solution.

It should be noted that third generation drugs show activity against gram-positive and negative microorganisms. The mechanism of action of the drug "Ceftriaxone" is based on its ability to disrupt the synthesis of the mucopeptide of the bacterial cell wall .

The drug is not subjected to hepatic transformation. This provides constant concentration in the body, and also allows the use of the drug for patients with renal and hepatic insufficiency. It is excreted from the body with urine and bile.

The drug is able to penetrate through inflamed meninges in children. One day after intravenous administration at a dosage of fifty to one hundred milligrams per kilogram of weight, the drug concentration in the cerebrospinal fluid exceeds 1.4 mg / ml. The maximum content of the drug reaches four hours after the introduction into the vein. On average, the level of medication in the blood is 18 mg / ml.

The antibiotic "Ceftriaxone" is able to pass through the placental barrier and penetrate into breast milk in insignificant concentrations. In milk, there are three to four percent of the serum level of the drug.

The antibiotic "Ceftriaxone" is prescribed in the treatment of a number of infectious lesions caused by sensitive microorganisms. Such diseases include lung abscess, pneumonia, mastoiditis, bronchiectasis, otitis media, gonorrhea, peritonitis, meningitis. The agent is indicated for infections in patients with weakened immunity and neutropenia.

The drug is prescribed for respiratory infections: bronchitis (acute and chronic), as well as pleural empyema. Indications include abdominal infections, gastrointestinal disorders, typhoid fever, salmonellosis, sepsis, bacterial endocarditis. Antibiotic "Ceftriaxone" is prescribed for infection of joints and bones, including in the maxillofacial area. In clinical practice, there is information about the successful use of the drug in chlamydial infection.

The appointment of "Ceftriaxone" during pregnancy is allowed in the case when the relationship between benefit to the mother and harm to the fetus is taken into account.

The drug regimen is determined by a specialist. As a rule, appoint one to two grams per day to patients with twelve years.

Depending on the severity of the infectious lesion, can be prescribed for 0.5-1 grams every twelve hours.