The drug "Sporagal": instructions for use, analogues and reviews

How should I take the drug "Sporagal"? Instructions for using the medication will be discussed later. Also, you will find out whether there are analogues for this drug, how much it costs, what patients are saying about it, for what purposes it is prescribed, etc.

Form, composition, packaging of an antifungal drug

The drug "Sporagal" comes in the form of capsules. Its main active ingredient is itraconazole. Also included in the formulation are polyethylene glycol 20,000, sucrose, hydroxypropylmethylcellulose and acrylate copolymer.

As for the shell, it consists of gelatin, titanium dioxide and indigotine.

In what kind of packaging is the "Sporagal" medication sold? Instructions for using this tool are embedded in a cardboard box. It also contains hard gelatin capsules of blue color (in blisters), inside which there are spherical granules of yellow color.

Pharmacodynamics of the drug

How do the Sporagal tablets work? According to the attached instructions, this medication is a triazole derivative. It has a high activity against fungi.

Admission of the drug helps to slow the biological synthesis of ergosterol, providing an antifungal effect.

Experts say that itraconazole blocks the growth and reproduction of a huge number of species of fungi.

Pharmacokinetics of an antifungal agent

The drug "Sporagal", analogues of which will be indicated below, is quickly absorbed into the bloodstream. The greatest level of itraconazole in the human body is observed after a lapse of 3 hours. Its bioavailability is 55% (the maximum is noted when taking capsules immediately after consuming fatty and high-calorie food).

Itraconazole is distributed to different organs and tissues of the body. Its content in bones, kidneys, liver, lungs, skeletal muscles, stomach and spleen is 3 times greater than in blood.

Metabolized medicine in the liver with the allocation of many derivatives. However, only hydroxyitraconazole has a pronounced antifungal effect.

Approximately 34% of the active substance is excreted together with urine and about 54% by the intestine.

In people with impaired liver and kidney function, as well as in patients with immunosuppression, the bioavailability of the drug may decrease.

Indications for use of capsules

What is the purpose of the "Sporagal"? The instruction says that this medication is intended for the treatment of mycoses that were provoked by pathogens that are sensitive to the drug:

• Candidiasis vulvovaginal;
• Ophthalmic and dermatological diseases of fungal origin (for example, fungal keratitis, dermatomycosis, pityriasis);
• Oral candidiasis ;
• Onychomycosis, which were provoked by dermatophytes or yeast;
• Systemic fungal infections, including cryptococcosis (for people with a weak immune system in cryptococcosis of the nervous system, medication is prescribed only in the absence of a treatment effect from other antifungal drugs), meningitis cryptococcal, systemic aspergillosis, and candidiasis;
• Sporotrichosis, paracoccidioidosis, blastomycosis, histoplasmosis, and other rare systemic mycoses.

Contraindications to the use of capsules

What are the contraindications to the use of the drug "Sporagal" (tablets)? The instruction says that this medication is forbidden to use when:

• Hypersensitivity to the main and auxiliary components of the drug
• Combination with such medications as Eletriptan, blockers of HMG-CoA reductase (for example, Atorvastatin, Lovastatin, Simvastatin), ergot alkaloids, substrates of CYP3A4 (for example, Cizapride, Bepridil, Pimozid , "Dofetilide", "Astemizol", "Quinidine", "Mizolastin"), "Nisoldipin", "Midazolam", "Triazolam".

It should also be noted that the use of this drug is contraindicated in people with ventricular dysfunction and heart failure, especially stagnant.

The drug "Sporagal": instructions for use

According to the instructions, this medication should be taken orally. Capsules should be consumed immediately after a meal (in order to ensure better absorption) in a general form, without chewing.

The dosage of this medication depends on the type of disease present:

• Dermatological and ophthalmic lesions (eg, pityriasis or dermatomycosis) are 200 mg once a day for a week.
• Keratinized lesions of skin areas (hands and feet) - 200 mg twice a day for a week.
• Candidiasis vulvovaginal - 200 mg twice a day for three days.
• Candidiasis oral - 100 mg once a day for two weeks. In patients with AIDS or neutropenia, the dose is increased to 200 mg once a day.
• Fungal keratitis - 200 mg once a day for three weeks.
• Onychomycosis, which was caused by dermatophytes or yeast fungi, is treated with repeated courses. One course of therapy involves taking two capsules twice a day for a week. For the treatment of nail lesions on the fingers, 2 courses of such therapy are carried out, and on the legs - 3 courses. The break between them should be 3 weeks. The effect is manifested after the completion of the courses (as the nail plates grow).

Evacuation of the drug "Sporagal" from the nails and the skin takes longer than from the blood. In this regard, optimal therapeutic effects in patients are achieved only after three weeks after the end of the course of infection therapy and approximately 9 months after the treatment of onychomycosis.

Methods of using capsules in systemic lesions

How to use the systemic lesions? "Sporagal" is prescribed in the following dosages:

• Candidiasis - 100-200 mg once a day for 5-30 weeks.
• Cryptococcosis without meningitis - 200 mg per day for 3-12 months. With a meningitis dose is doubled.
• Aspergillosis - 200 mg per day for 3-5 months.
• Histoplasmosis - 200 mg twice a day for eight months.
• Chromomycosis - 100-200 mg per day for six months.
• Sporotrichosis is 100 mg per day for three months.
• Paracoccidioidosis - 100 mg a day for six months. For patients with AIDS, the dosage can be increased.
• Blastomycosis - 100-200 mg twice a day for six months.

Side effects of the drug

Are there any side effects when taking Sporagal? References from specialists report the following reactions:

• Neutropenia, thrombocytopenia, leukopenia;
• Infections of the respiratory tract (upper);
• Hypertriglyceridemia, hypokalemia, hypocalcemia;
• Headache, paresthesia, peripheral neuropathy, hypoesthesia, dizziness;
• Serum sickness, angioedema edema, anaphylactoid anaphylactic and allergic reactions;
• Blurred vision, diplopia, hearing loss, tinnitus, impaired vision;
• Heart failure, especially stagnant;
• Shortness of breath, rhinitis, sinusitis, pulmonary edema;
• Vomiting, dyspepsia, hepatotoxic reactions, abdominal pain, pancreatitis, nausea, dysgeusia, constipation, hepatitis, diarrhea, bloating, temporary increase in hepatic transaminase;
• Pain in the joints and muscles;
• Urticaria, photosensitivity, leukocytoclastic vasculitis, alopecia, toxic epidermal necrolysis, pruritus, exfoliative dermatitis, rash, generalized pustulosis acute exanthematous, erythema multiforme;
• Dysmenorrhea, urinary incontinence, erectile dysfunction, pollakiuria;
• Fever, swelling.

Special Recommendations

What should the patient know before taking Sporagal? Reviews report that his active substance has a negative inotropic effect.

Against the background of taking this medication, congestive heart failure may develop, as well as severe hepatotoxicity.

With reduced acidity, the absorption of the drug worsens.

People who use antacids at the same time should observe an interval of 2 hours between their methods and the drug described.

The drug "Sporagal" is not recommended for elderly patients.

When symptoms of peripheral neuropathy appear, the medication should be withdrawn.

Breastfeeding and pregnancy

During pregnancy, a medication can be prescribed only with systemic fungal infections that threaten the mother's life.

As for breastfeeding, during this period, "Sporagal" is allowed to use, but only on strict indications.

The drug "Sporagal": analogues and price

The most well-known analogues of the drug in question are the following: Itrungar, Sporaksol, Orungal, Eszol, and Funit.

How much does the drug "Sporagal" cost? The price of this medicine varies between 1100-1200 rubles.

Reviews about the drug

According to the reviews of those who took this medication, it can be noted that it shows itself quite effectively with various types of fungal lesions. From negative messages it is possible to allocate those in which it is spoken, that this means has high cost. However, experts argue that the price of this drug is fully justified by its therapeutic effectiveness.

With regard to the shortcomings of this medication, patients often indicate a fairly long period of treatment.