Antibiotic "Glevo": reviews of doctors

What is and how is the Glevo 500 used? Instructions for use, reviews and features of this medication are described below. Also in the materials of this article you will find evidence for taking this medicine and prohibiting its use.

Packaging of medicament, its form, description, composition

In what form is the drug "Glevo" manufactured? The reviews claim that the drug is delivered to drugstore counters in the form of tablets. They have a film-colored brick-red shell, a round and biconvex shape, and a fault line on one side.

What does the "Glevo" drug contain? The doctors say that levofloxacin is the main substance of this medicine. It also includes such auxiliary ingredients as crospovidone, microcrystalline cellulose, povidone, starch and magnesium stearate.

The tablet shell contains: dibutyl phthalate, hypromellose, titanium dioxide, macrogol, red dye (iron oxide), and talc.

In the sale of the drug "Glevo" comes in blisters, which are packaged in packs of cardboard.

Action medication

What is "Glevo 500"? Instructions for use, the reviews say that this is an antibacterial agent belonging to a group of fluoroquinolones (has a wide range of activities).

The main component of this drug (levofloxacin) is able to block the DNA-gyrase (i.e., topoisomerase 2) as well as the topoisomerase 4. In addition, this substance disrupts crosslinking and supercoiling of DNA breaks, suppresses its synthesis, causes morphological changes (deep) in membranes, cellular Walls of bacteria and the cytoplasm.

The drug "Glevo", whose reviews are ambiguous, is active against many Gram-positive aerobic microorganisms.

Kinetic features

Where is the absorption of the drug "Glevo"? Instruction, reviews report that when taking the medicine inside, it is quickly and completely absorbed from the intestine. The intake of food has virtually no effect on the completeness and speed of absorption of the drug.

The biological availability of this drug is 99.5%, and the maximum concentration in the blood is observed after 2 hours.

The association of the drug with plasma proteins is approximately 33-40%. It penetrates well into tissues and organs, especially the lungs, sputum, bronchial mucosa, polymorphonuclear leukocytes, urogenital organs and alveolar macrophages.

In the liver, a small part of the drug is oxidized or deacetylated.

The half-life of this drug is 6-8 hours. It is excreted from the body through the kidneys.

Indications

When should I use the antibiotic "Glevo"? The doctors say that this remedy is effective in inflammatory and infectious diseases caused by bacteria that are sensitive to the drug. Thus, the drug in question is prescribed for infections:

• ENT organs (including acute sinusitis);
• Infections (uncomplicated and complicated) kidneys and urinary tract (including prostatitis and pyelonephritis of acute type);
• Respiratory tract, more precisely, its lower sections (including community-acquired pneumonia and exacerbations of chronic bronchitis);
• Genital organs;
• The abdominal cavity (in combination with agents that affect the anaerobic flora);
• Soft tissues and skin (including festering atheromas, furunculosis and abscesses).

Prohibitions to use

At what conditions should not be prescribed antibiotic "Glevo"? The reviews indicate the following contraindications for this remedy:

• Period of pregnancy;
• epilepsy;
• Underage age;
• The defeat of tendons, which arose with the previous treatment with quinolones;
• breast-feeding;
• Hypersensitivity to levofloxacin and other fluoroquinolones.

With special care, the drug in question should be given to elderly people (because of the high probability of reducing kidney function), as well as when there is a shortage of glucose-6-phosphate dehydrogenase.

Glevo tablets: instructions for use

The reviews say that this medication should be taken orally twice a day. Tablets should be swallowed in their entirety. They are not allowed to chew (it is advisable to drink plenty of water).

The drug can be consumed before meals or between meals.

The dosage of this drug is determined by the severity and nature of the infection, as well as the sensitivity of the pathogen.

• With sinusitis medication is prescribed for 500 mg (once a day) for two weeks.
• With exacerbation of chronic bronchitis - 250 or 500 mg (once a day) for one week.
• For community-acquired pneumonia, 500 mg (twice daily) for two weeks.
• In infections of urinary tracts of uncomplicated nature - 250 mg (once a day) for three days.
• With prostatitis - 500 mg (once a day) for one month.
• In infections of urinary tract complicated by nature (including pyelonephritis) - 250 mg (once a day) for 10 days.
• When infections of soft tissues and skin - 250-500 mg (twice a day) for two weeks.
• With infections of the abdominal cavity - 500 mg (once a day) for two weeks (in combination with antibacterial agents that affect the anaerobic flora).

In case of impaired liver function, no special selection of doses is required, since the metabolism of levofloxacin in the liver occurs to a small extent.

For the elderly, a change in the dosing regimen is not required, except for low QC.

Treatment with this drug should be continued about 48-78 hours after eradication and normalization of body temperature.

If you miss a medication, you should take the pill as soon as possible. Further it is required to continue the use of the drug according to the prescribed scheme.

Side effects

What are the negative effects of the drug "Glevo 500"? The responses indicate the following reactions:

• Nausea, decreased blood pressure, vomiting, vascular collapse, diarrhea, hypoglycemia, digestive disorders;
• Arthralgia, decreased appetite, muscle weakness, abdominal pain, visual and hearing impairment;
• Pseudomembranous enterocolitis, interstitial nephritis, increased transaminase activity of the liver, rhabdomyolysis;
• Hyperbilirubinemia, deterioration of smell, tactile and taste and sensitivity, hepatitis, tendonitis, dysbiosis;
• Myalgia, tachycardia, acute renal failure, urticaria, atrial fibrillation;
• Headache, hypercreatininaemia, dizziness, hemolytic anemia, weakness, agranulocytosis;
• Drowsiness, swelling of the skin and mucous membranes, insomnia, anaphylactic shock, tremor, vasculitis, restlessness, neutropenia, paresthesia;
• Allergic pneumonitis, fear, suffocation, hallucinations, exacerbation of porphyria, confusion, pancytopenia;
• Depression, thrombocytopenia, motor disorders, persistent fever, epileptic seizures, rupture of tendons;
• Leukopenia, itching and hyperemia of the skin, asthenia, erythema malignant exudative, eosinophilia;
• Necrolysis toxic epidermal, bronchospasm, development of superinfection, hemorrhage, photosensitivity.

Analogues and cost

The price of this product is about 170-250 rubles. In some cases, this drug is replaced with drugs such as Levolety, Zolev, Toksof, Lebel, Levofloxacin, Levobaks, Levoflox, Levobakt, Levotor, Levokils, "Levostad", "Levoksa", "Levomak", "Levoximed".

Antibiotic "Glevo": reviews of patients and doctors

Reviews of consumers about the drug "Glevo" are ambiguous. They can be divided into 2 groups: one part is happy with the action of the medicine, as it helps to cope with infectious diseases with minimal side effects, and the other - considers the drug ineffective.

As for doctors, their opinion boils down to the fact that the drug "Glevo" is a strong antibiotic, which can be taken only after consultation with the doctor. By the way, most specialists together with the medicine in question recommend taking probiotics so as not to disrupt the intestinal microflora.