The drug 'Famotidine'. Instructions for use

The drug "Famotidine" is a medicine used for gastrointestinal diseases. It is a competitive histamine antagonist. "Famotidine", the mechanism of its action directed at H2 histamine receptors in parental cells, significantly reduces the production of hydrochloric acid, provoked by different stimuli. The secretion of pepsinogen is inhibited in a smaller volume. The drug "Famotidine" provokes a dose-dependent suppression of the production of hydrochloric acid and a decrease in the activity of pepsin. When taking the medicine, there is a significant change in the level of gastrin in the plasma.

The duration of the effect after a single use of the drug depends on the dosage. Typically, the duration of the action - from twelve to twenty-four hours.

The "Famotidine" application guide recommends adults with an exacerbation of ulcers of the duodenum or stomach, erosive gastroduodenitis, symptomatic ulcers once a day for forty milligrams or twice a day for twenty milligrams. In agreement with the doctor, if necessary, the daily dosage may be increased to 80-160 mg. Duration of treatment - from one to two months.

To eliminate signs of dyspepsia, provoked by a strengthened secretory gastric function, the drug "Famotidine" instruction for use recommends taking twenty milligrams one or two times a day.

To prevent the recurrent development of peptic ulcer, appoint once a day for 20 mg (at night).

Treatment of reflux esophagitis is carried out by applying the drug at a dose of 20-40 mg twice a day. The duration of therapy is from one and a half to three months.

The preparation "Famotidine" instruction for use allows for the appointment of children from three years of age. The recommended dose is 2 milligrams per kilogram of weight (at a weight of more than ten kilograms) or 20 mg twice a day, but not more than 40 mg.

Among adverse events with the use of the drug "Famotidine" instruction for use notes the development of acute pancreatitis, hepatitis, increased activity of hepatic enzymes, anorexia. The drug can provoke flatulence, dry mouth, diarrhea, flushing, hallucinations. Negative effects include psychosis, nervousness, depression, drowsiness, fatigue, tinnitus. Probably the appearance of dizziness, insomnia. Side effects include atrioventricular blockade, arrhythmia, bradycardia, vasculitis, lowering of pressure, bronchospasm, acne, dry skin, hypersensitivity reactions.

With prolonged medication "Famotidine" impotence is noted, the concentration of urea increases in the blood, libido decreases, articular, muscle pains, febrile conditions occur.

special instructions

It is necessary to exclude before the beginning of the therapy the probability of the patient having malignant formations in the duodenum, esophagus or stomach, in connection with the ability of the drug "Famotidine" to hide the symptoms.

After elimination of symptoms of ulcers, continued treatment is recommended until the results of X-ray or endoscopic examination confirm scarring.

The drug "Famotidine" should be abolished gradually, in connection with the likelihood of the syndrome "ricochet".

Long-term treatment, as well as finding a patient under stress during therapy can provoke stomach lesions of a bacterial nature with the subsequent spread of the infectious process.

In case of an overdose, there is a collapse, tachycardia, tremor, hypotension, motor excitement. It is necessary to rinse the stomach or induce vomiting. Subsequently, symptomatic therapy is indicated.

Analogues of "Famotidine" include such drugs as "Atodine", "Acipept", "Famocid", "Gastrozidin" and others.