The drug "Nitroxoline" (indications for use)

One of the most popular antimicrobial drugs, which have a strong antibacterial effect on gram-negative and gram-positive microbes, are Nitroxoline tablets. Indications for their appointment are very diverse. This medication has many other names: "Nibiol", "5-Nitrox", "Nikinol", "5-NOC", "Nicopet", "Noxibiol", "Noxin", "Niuron", "Uritrol". All these medicines are essentially the same drug.

The active substance of this drug is a derivative of oxyquinoline-nitro-8-hydroxyquinoline. This substance is a fine crystalline powder of a yellowish-green color, practically insoluble in water. Powder stops the replication of nucleotides and forms complexes with certain enzymes of the microbial cell, which causes a strong bacteriostatic effect. The drug is active against staphylococci, streptococci, causative agents of gonorrhea, proteas, salmonella, shigella, trichomonads, mycobacteria, enterobacter and other pathogenic microorganisms that cause various infections.

The agent is released in tablets of 0.05 g, coated with an orange coating. The package contains 50 tablets. Indications for the use of the drug are very numerous. It is used for various infections of the urogenital tract, such as urethritis, cystitis, prostatitis, pyelonephritis and other diseases. The drug "Nitroxoline" quickly and almost completely absorbed in the gastrointestinal tract. The kidneys are excreted unchanged.

The drug "Nitroxoline" for cystitis and other infections of the genitourinary system take 4 r. Per day to 0.1 g. For the prevention of postoperative infections of the urinary tract and kidney appoint a 2-3-week four-time medication for 0.01 g. In combination with other antibacterial drugs, the effectiveness of treatment with the drug "Nitroxoline" is increased. Indication for complex therapy is a stable pathogenic microflora. The duration of treatment with this drug depends on the severity of the disease and its nature. The course of therapy - 2-3 weeks. If necessary, it is carried out several times with a break of 2 weeks.

Tablets "Nitroxoline", the instruction to which indicates their effectiveness against some pathogenic fungi, are actively used to treat candidiasis and other fungal diseases.

In some severe cases, the use of elevated doses of Nitroxoline tablets is prescribed. Indications for increased dosage: chronic infections, infection of wounds after kidney surgeries. In such cases, the drug is taken four times a day for 0.15-0.2 g. The daily maximum dose of the drug for adults is 0.8 g.

For children from 5 years, the optimal daily dose is 0.2-0.4 g. The drug is taken 4 r. Per day for 0.05-0.1 g. Children under 5 years of age take the drug at 0.2 g per day (4 rivers at 0.05 g).

The drug is normally transferred, but occasionally when it is taken, nausea is observed. To prevent this phenomenon, you should take the pill while eating. Very rarely there are allergic skin rashes. Particular care should be taken in patients with renal insufficiency, which is prescribed for taking Nitroxoline tablets. The indications in this case should be very significant, because when taking this drug, its active cumulation can be observed. During the period of treatment with this drug, patients urine is colored in saffron color.

The drug is contraindicated in susceptibility to oxyquinoline derivatives; With violations of the kidney function, accompanied by anuria, oliguria; With severe liver disease; Neuritis, cataract, polyneuritis; Pregnancy and lactation.

Store the drug in a dark dry place. It is released by prescription.