"Fluanksol": instruction manual, doctor's comments. Side effects of "Fluanxol", analogues of the drug

What is the "Fluansoxol" medication? Instructions for the use of this drug, its composition, side effects, form of release and pharmacological characteristics will be described in detail in this article. From it you will learn also about what contraindications and indications the mentioned preparation has, how much it costs, what will happen in case of an overdose, etc.

Composition of the drug and the form of its release

What active ingredient does the drug "Fluanxol" contain? The instruction for the use of this medication states that flupentixol hydrochloride acts as an active ingredient.

As for the form of release, today this remedy can be found only in drops, tablets and an oil-based solution intended for intramuscular administration. The first medicine goes on sale in an occlusive glass of 10 ml, the second - in a cardboard package of 100 or 50 pieces, and the third - in ampoules of 10 pieces.

General properties of the preparation

What is the purpose of the "Fluansoxol" medication? Patients' comments about this drug will be provided below. Tablets and solution for injection belong to the group of antipsychotic drugs. They have an anxiolytic, antidepressant and soothing effect. Positive feedback about this drug contains information that it effectively activates the emotional state of the patient and contributes to his social adaptation.

Pharmacological characteristics of the drug

What are the pharmacological characteristics of the drug "Fluanxol"? Instructions for use suggest that this drug is an antipsychotic that blocks adrenoreceptors and dopamine receptors in the brain. As a result of the action of the active substance, a sedative effect is achieved . As a rule, this occurs during 8 days of regular intake of the drug.

What do patients say about the drug "Fluansoxol"? The patients' reviews contain a lot of interesting information. In most cases, they note that this drug quite quickly eliminates symptoms of psychosis and depression, and also helps restore thinking. Patients who had antisocial disorders become communicative and adapt in society.

Features of the drug

How does the Fluanxol medication work? Reviews of doctors and other specialists say that the peculiarity of this drug is that depending on the dose, it can act on the patient in different ways.

The antipsychotic effect of the drug is manifested after the application of the agent in an amount of 3 mg per day. By the way, the intensity of this effect increases with the increase in dosage.

In the amount of up to 25 mg per day, the drug does not have a sedative effect. However, it should be noted that in higher doses, it can cause nonspecific sedation.

In the entire range of prescribed doses, the neuroleptic agent has a pronounced anxiolytic effect. When using small doses (up to about 3 mg per day), the drug can serve as an ordinary antidepressant drug.

Thus, the drug "Fluanxol" is able to reduce the main signs of psychosis, including paranoid nonsense, hallucinations and violation of thinking. It has disinhibitory properties (i.e., activating and anti-attic), and also reduces mood disorders, which ultimately contributes to the activation of patients with depressive symptoms, facilitates their social adaptation and increases their communication skills.

In detail about the injection form

The drug "Fluanksol Depot" is an oily solution intended for intramuscular depot injections. In other words, this medication is a deposited form of flupenthixol.

When using such a solution in small as well as medium dosages (up to 100 mg every 14 days), the patient does not have a nonspecific sedative effect. Although it does develop at high doses.

What do experts say about this form of the drug ("Fluanxol Depot")? Reviews say that such a solution has a long duration of exposure to the patient, rather than the drug in tablets. Moreover, thanks to it, it is possible to carry out continuous antipsychotic treatment easily, which is extremely important for patients who do not comply with medical prescriptions.

From all of the above, it can be concluded that the drug "Fluanksol Depot" is able to prevent frequent relapses associated with spontaneous interruption of therapy. Intramuscular injections can be administered at intervals of two or four weeks.

Pharmacokinetics

How long do I take Fluanxol tablets? After oral administration, the maximum concentration of the active element in the plasma is reached after about 3-7 hours. Bioavailability of the drug is 40%.

The active element of the drug penetrates insignificantly through the placental barrier. It should also be noted that in small amounts it is excreted in mother's milk. By the way, metabolites do not have neuroleptic activity.

How does the fluoxane Depo injection work? The guideline states that after intramuscular injection, the cis (Z) -flupentientol dexanoate substance is cleaved (enzymatically). In this case, the active element cis (Z) -flupentixol and decanoic acid are formed. The maximum concentration of the first in the serum is reached by the end of the 1st week after the injection.

When taking the tablets inside the period of their removal is about 35 hours. If an injection for injection has been used, the concentration in the serum decreases exponentially (after 3 weeks).

This medication is given in the form of metabolites through the intestine, as well as by the kidneys.

Indications for use of antipsychotics

In what cases is the drug "Fluanxol" shown? Its effect can be different, depending on the dosage.

The drug is indicated in doses up to 3 mg per day with the following pathological conditions:

• Moderate and mild depression, accompanied by asthenia, anxiety and lack of initiative;
• Psychosomatic disorders that manifest themselves with asthenic reactions;
• Neurotic disorders (chronic), accompanied by apathy, depression and anxiety;
• Situational and acute anxiety disorders, as well as conditions of excessive emotional stress that do not require a sedative or hypnotic effect (for example, if the patient abuses tranquilizers).

The "Fluansoxol" medication, analogues of which will be presented at the end of the article, is prescribed at dosages of 3 mg per day or more if there are the following deviations: psychotic conditions accompanied by paranoid delusions, hallucinations, thinking disorders, anergia, apathy and autism.

Contraindications to the use of antipsychotics

In what cases is it not recommended to use the drug "Fluanxol"? Instructions for use include the following list of contraindications:

• The age of children (up to 18 years);
• Oppression of the central nervous system;
• Lactation period;
• Period of pregnancy;
• Intoxication (acute) with barbiturates;
• collapse;
• Intoxication with opioid analgesics acute;
• Pheochromocytoma;
• Alcoholic poisoning is acute;
• Comatose conditions;
• Bone marrow suppression;
• Changes in blood pathological;
• Hypersensitivity to neuroleptics with a thioxanthene structure.

It should also be noted that in the state of hyperactivity or excitation, it is not recommended to prescribe the drug in small dosages (up to 3 mg).

The drug "Fluanksol": instruction (tablets, drops)

For the treatment of anxious and depressive disorders, the initial dosage of medication in tablets should be 1 mg once a day (preferably in the morning) or 500 μg twice a day. If there is no therapeutic effect, then in a week the amount of the drug can be increased to 2 mg. In this case, the daily dosage (2-3 mg) should be divided into several receptions. If the effect is absent when using the drug at the maximum dose (ie 3 mg), then it should be discarded.

In the treatment of psychotic conditions, the amount of medication is determined only individually. The initial daily dosage should be 3-15 mg in 3 divided doses. If necessary, this amount can be increased to 20 or 30 mg per day. The maximum dosage should not be more than 40 mg.

As a supportive treatment, the agent is prescribed in an amount of 5-20 mg once a day (in the mornings).

As for the drops "Fluanksol", they should be taken only inside. Usually, doctors prescribe this form of the drug only if for any reason it can not take the medicine orally (in tablets). The maintenance dosage for patients is 4-40 mg per day.

Injection solution "Fluanksol": instructions, patient reviews

The oily solution for intramuscular depot injection must be injected deep into the outer upper quadrant of the buttock. Dosages and the interval between procedures should be established only individually (depending on the therapeutic effect).

This drug is usually used in an amount of 20-40 mg (or 1-2 ml) every 2 or 4 weeks. It should be specially noted that some patients may require large dosages and a short interval between injections.

If the prescribed volume of medicament for injection (20 mg / ml) exceeds 2 or 3 ml per procedure, then it is necessary to switch to a solution with a high concentration.

The drug 100 mg / ml should be administered in a volume of 50-200 mg (or 0.5-2 ml) every 2-4 weeks. In case of acute relapse or exacerbation of the disease, one-time administration of the agent in an amount up to 400 mg at intervals of 2 or 1 week is sometimes required. After acute symptomatology passes, it is necessary to gradually reduce the dosage to maintenance (20-200 mg every 2-4 weeks).

If it is required to switch from the oral form of the drug to maintenance therapy with a parenteral drug, it is recommended to rely on the following scheme:

• Daily amount (in mg) of medication in tablets x 4 = single dose (in mg) of the injection solution every 14 days.

It should also be noted that within one week after drug administration it is recommended to continue taking the drug in tablets, but in a smaller dose. The subsequent volume and the gap between the procedures are established in accordance with the therapeutic effect.

The maximum dosage of the injection solution (one-stage) is about 400 mg. The interval between injections should be one week.

According to the patients' feedback, with proper use of the drug and compliance with medical recommendations, it positively affects their overall emotional state.

Side effects

Can the Fluanxol medication affect the body in a negative way? Side effects are available for this drug, regardless of its form. Let's list them right now.

1. Nervous system: hyperkinetic-hypertonic syndrome (extrapyramidal lung), weakness, akathisia, fatigue, dizziness, psychomotor retardation, tardive dyskinesia, dystonic and neuroleptic malignant syndrome reactions.
2. Heart and blood vessels: tachycardia, orthostatic hypotension.
3. Hemopoietic system: granulocytopenia.
4. Sense organs: violation of accommodation.
5. Gastrointestinal tract: constipation, cholestatic jaundice, dry mouth, transient changes in liver tests.
6. Endocrine system: weight gain, galactorrhea, sweating, gynecomastia, impotence, dysmenorrhea, increased appetite, decreased libido, hot flashes.
7. Urinary system: retention of urine.
8. Allergy: dermatitis, photosensitization and skin rash.

Special instructions for use

With special care, the medication is prescribed to patients with cardiovascular abnormalities, convulsive syndrome, respiratory failure, glaucoma, Parkinson's disease, gastric and duodenal ulcer, asthma, alcoholism, emphysema, urinary retention, hepatic insufficiency and prostatic hyperplasia.

If the patient has previously taken antipsychotics or tranquilizers with sedative effect, then their reception should be stopped smoothly.

With long-term treatment, especially at high dosages, it is recommended to monitor and assess the patient's condition with a view to correcting the maintenance dose.

With simultaneous therapy of diabetes, the purpose of this drug may require correction of the volume of insulin.

When neuroleptics are used, malignant neuroleptic syndrome may develop . Its main symptoms are muscle rigidity, hyperthermia, impaired consciousness and dysfunction of the autonomic nervous system. With such signs, urgent withdrawal of the drug and the appointment of maintenance symptomatic therapy.

In most cases, the drug "Fluanksol" does not cause sedation. But despite this, one should consider its possible impact on the ability to safely control the machine or other mechanisms. Also I want to note that during therapy (especially at the very beginning) patients should avoid potentially dangerous jobs (before determining the reaction to the drug).

Cases of overdose

If the medicine is taken incorrectly (in high volumes), then an overdose may occur. In this case, the following symptoms appear: hypo- or hyperthermia, drowsiness, convulsions, extrapyramidal disorders, shock, arterial hypotension and coma.

What to do in this situation? Supportive and symptomatic therapy is necessary. If the drug was taken orally, then it is required to quickly wash the stomach, and also take the sorbent. In addition, it is extremely important to maintain the activity of the vessels, heart and respiratory system. It is not recommended to use epinephrine, since it can lead to a decrease in blood pressure. Extrapyramidal signs can be stopped with the drug "Biperiden", and convulsions - "Diazepam".

Interaction with other drugs

With the simultaneous use of this medication, the sedative effect of barbiturates, ethanol and other agents that exert a depressant effect on the central nervous system may be enhanced.

The drug "Fluanksol" is highly not recommended to be used together with the substance of guanethidine and drugs with similar effects. This fact is due to the fact that neuroleptics can significantly weaken their hypotensive effect.

With a one-time use of the drug "Fluanksol", it can lower the effectiveness of the drug "Levodop" and other adrenergic drugs.

With the simultaneous administration of the drug with Piperazine and Metoclopramide, the risk of extrapyramidal disorders is significantly increased.

It should also be noted that the presented antipsychotic medication in the form of an injection solution should never be mixed with other liquids.

Price and analogues of the preparation

How much does the drug "Fluansoxol" cost? Its price is quite high. So, for 50 tablets of 1 mg you will have to give about 500 Russian rubles. If you need 100 tablets of 5 mg, they can be purchased for 1200 rubles. As for the injection form of the drug, it is even more expensive. For 10 ampoules (20 mg / ml), pharmacists require about 2300 rubles.

What should I do if the patient was unable to purchase the Fluanxol medication? Analogues of it are sold practically in all chemist's networks. Among them are the following:

1. Mortar "Fluanksol Depot". It is a faster and stronger drug. However, it is much more expensive than tablets.
2. The medicine "Klopiksol". At its cost is very close to the original. It goes on sale in tablets and has few contraindications.
3. Means of "Truksal". Sold in tablets. The main advantage is its use for children from 3 years old. The cost is slightly higher than the original.