Candles "Flexen": instructions, reviews, prices, analogies

Candles "Flexen" refer to the pharmaceutical group of NSAIDs (non-steroidal anti-inflammatory drugs). They have anti-inflammatory, antipyretic, analgesic and anti-aggregation effects. The present drug blocks the activity of enzymes (cyclooxygenases 1 and 2) and the synthesis of prostaglandins. This process prevents the formation of inflammatory mediators and inhibits the appearance of leukotrienes.

"Flexan" candles show anti-bradykinin activity, stabilize lysosomal biomembranes, cause inhibition of neutrophil activity in patients diagnosed with rheumatoid arthritis. Suppress the aggregation of platelets. The analgesic effect is due to both central and peripheral mechanisms. Many doctors prescribe "Flexen" (candles) for pain relief and treatment of arthritis. The price of the drug allows you to buy it to different categories of patients. The testimonials on the drug testify to its high efficiency and safety for health, while observing the relevant recommendations.

Instructions for the use of the drug is quite simple, and the reviews confirm the apparent therapeutic effect. What is the composition of the medicine? What properties does it have? Are there dangerous side effects? Many patients are looking for answers to these questions.

Chemical Composition of the Drug

The preparation includes a complex of bioactive and auxiliary substances:

• Ketoprofen (basic bioactive compound);
• beeswax;
• Hydrogenated vegetable oil;
• Silicon dioxide colloid;
• Ethylparahydroxybenzoate sodium;
• sorbitol;
• gelatin;
• vegetable oil;
• Glycerol;
• Soy lecithin;
• titanium dioxide;
• Propyl parahydroxybenzoate.

"Flexen", candles: analogues

In therapeutic practice, physicians quite actively use the analogues of the above drug:

• "Artrozilen."
• Ketonal Duo.
• Artrum.
• «Bystrumgel».
• "Valusal".
• Bystrumcaps.
• Ketonal.
• "Orewvel."
• "Fibrofit."
• "Flamax".
• Profenid.
• Ketonal uno.

Advantages

The main advantages of the medicine include the following indicators:

• Maximum therapeutic effect;
• High bioavailability of the drug in comparison with its analogues.

Disadvantages of the medicine

The main disadvantages of Flexan include the following criteria:

• High price of medicines in comparison with analogues;
• There is no daily (prolonged) form of release available.

Pharmacokinetics

Binding of bioactive substances of the drug with blood plasma proteins is 99 percent. Candles "Flexen" are characterized by high bioavailability (more than 90%). The therapeutic concentration of Flexan in the blood is maintained for 6 hours. The main metabolic cleavage of the drug occurs in hepatocytes by glucoridation. Half-life is about two hours. The drug is not cumulated, excreted mainly by the kidneys and through the intestine.

"Flexen" (candles): instructions for use, price

The above drug exhibits a broad therapeutic spectrum of action. In clinical practice, in the treatment of pain syndrome and inflammatory reactions of various genesis, the "Flexen" candles are often prescribed. The use of the drug is recommended for the following pathologies:

• migraine;
• Psoriatic arthritis;
• Tenosynovitis;
• renal colic;
• Gouty arthritis;
• bursitis;
• Dorsalgia;
• Myalgia;
• rheumatoid arthritis;
• otitis;
• Osteoarthrosis of different localization;
• Rheumatic polymyalgia;
• Bone pain;
• Ischialgia;
• phlebitis;
• Ankylosing spondylitis;
• neuralgia;
• Thrombophlebitis;
• radiculitis;
• Adnexitis;
• Pathology in the lumbosacral plexus;
• Ischialgia;
• Algodismenology;
• Postoperative and post-traumatic syndrome ;
• Lymphangitis;
• Pain syndrome in oncological pathologies.

To buy the drug "Flexen", the price of which varies in the range of 200-300 rubles, with the prescription available in any pharmacy. It is also worth noting that the "Flexen" candles in gynecology are often used, they are prescribed for ovarian cysts. According to many patients, the medicine works quite effectively. Many doctors claim that after treatment with "Flexen" for 10 days and subsequent taking additional medications the cyst disappears.

Contraindications

If you decide to use Flexen (candles), the instructions for use indicate that this medication should not be used in the following cases:

• Bleeding in the gastrointestinal tract;
• Severe dysfunction of the liver and kidneys;
• Lactation period and pregnancy;
• Hypersensitivity to non-steroidal anti-inflammatory drugs;
• hemorrhoids;
• "Aspirin" asthma;
• Bleeding disorders ;
• Proctitis;
• Age up to 15 years;
• Dysfunction of the hematopoiesis system (leukopenia, hemocoagulation disorders, thrombocytopenia, hemophilia);
• Diseases of the digestive tract in the phase of exacerbation.

Special instructions

"Flexen" (candles) instruction shows the appointment with special caution to patients with dysfunction of the kidneys, liver, digestive tract, bronchial asthma, alcoholism, rhinitis, polyps on the nasal mucosa, dehydration, hives, smoking, cirrhosis, hyperbilirubinemia, blood diseases, Sepsis, diabetes mellitus, cerebrospinal pathologies, and elderly people. In the process of treatment, this medication requires systematic monitoring of kidney and liver function. If the "Flexen" candles are prescribed together with anticoagulants (heparin), the risk of bleeding increases. A long therapeutic course is possible only in a hospital. During treatment avoid drinking alcohol.

Side effect

Have you been appointed "Flexen" (candles)? Instructions for use do not preclude the development of side effects. It:

• Severe headaches;
• nausea;
• heartburn;
• dizziness;
• Vomiting;
• Decreased appetite;
• insomnia;
• Gastrointestinal hemorrhages;
• asthenia;
• drowsiness;
• conjunctivitis;
• Xerophthalmia;
• nervousness;
• constipation;
• noise in ears;
• forgetfulness;
• Blurred vision;
• hepatitis;
• Hearing loss;
• Vertigo;
• Peripheral neuropathy;
• Gastralgia;
• tachycardia;
• Transient dysuria;
• hyperemia;
• eczema;
• cystitis;
• Nephrotic syndrome;
• urethritis;
• Photodermatitis;
• Swelling of the larynx;
• Hematuria;
• Exudative erythema;
• Renal dysfunction;
• Edematous syndrome ;
• Itching of the skin;
• Skin allergies;
• Increased activity of aminotransferases (alanine and aspartate aminotransferase) in blood serum;
• dyspnea;
• rhinitis;
• nose bleed;
• Bronchospasm;
• anaphylactic shock.

The use of suppositories can also cause diarrhea, a burning sensation and tenesmus.

Symptoms in case of drug overdose

Candles "Flexen" are intended for rectal use - 1 suppository (100 mg) 1-2 times a day. The maximum permissible daily dose of ketoprofen is 300 mg. When an overdose of the drug, the following symptoms are observed:

• Dysfunction of the liver and kidneys;
• drowsiness;
• nausea;
• bleeding;
• Severe pain in the epigastric region;
• Vomiting.

If the above signs are detected, symptomatic therapy is prescribed. Specific antidotes do not exist. Adsorbents are activated charcoal, Sorbeks, Medetopek or Neointestopan. Hemodialysis, forced diuresis - ineffective methods of treatment. Assign alkalizing drugs that alleviate the symptoms of the digestive canal. If necessary, glucocorticoids can be used. With renal failure, hemodialysis is performed. When convulsions are prescribed "Diazepam" or other benzodiazepane anticonvulsant drugs; In severe hypotension, plasma substitutes are introduced (Reopoliglyukin, Polyglyukin, Enterodez, Polidez, Gemodez). The patient requires constant observation for several days, since there is a danger of later manifestation of some gastrointestinal pathologies (bleeding, ulceration).

Interaction with other medicines

Strengthens the effect of anticoagulants, fibrinolytics, ethanol, antiaggregants, reduces the effect of peripheral vasodilators, spironolactone, the effectiveness of uricosuric medicines, hypotensive drugs and diuretics. The above medication is incompatible with "Tramadol". The joint application of Flexan with other non-steroidal anti-inflammatory drugs, ethyl alcohol, glucocorticosteroids, corticotropin provokes the formation of ulcers and the development of gastrointestinal bleeding. Antacids reduce the effectiveness of absorption of the drug. Two days before the test for the content of 17-ketosteroid, the drug is canceled.

"Flexen" increases the hypoglycemic effect of insulin, as well as oral hypoglycemic drugs. Myelotoxic medicines increase the manifestation of hematotoxicity of the drug. Inducers of microsomal biooxidation in the liver ("Phenylbutazone", ethanol, tricyclic antidepressants, "Phenytoin", "Rifampicin", barbiturates) activate the biosynthesis of hydroxylated active metabolites. Simultaneous application of Flexan with sodium valproate causes disruption of platelet aggregation.

Reviews about the drug

Many patients are interested in the question of what the "Flexen" candles actually are. Instructions for use, the cost of the drug, indications and contraindications are, of course, the main points. Nevertheless, it is worth familiarizing with the opinions of specialists and patients on this matter. Most doctors believe that the best analgesic and anti-inflammatory drug is Flexen (candles). Patients' responses in most cases (from 80 to 90%) are positive, which is due to the high effectiveness of the drug, reliable relief of pain of different etiology and localization, long-lasting effect, and ease of use. Positive effect can be noted already from the first days of admission. Negative reviews of the drug are mainly associated with the emergence of side effects and its cost, but such minuses of the drug are not able to eclipse its high efficiency.

Terms of leave from pharmacies

The drug in the form of suppositories and capsules is released strictly according to the doctor's prescription. The drug in the form of a gel can be dispensed without a prescription.

Storage conditions

Keep out of the reach of children at a temperature of no higher than 25-30 ° C. The specified temperature regime applies to all forms of release. Shelf life is indicated on the package. The drug should not be taken after the expiration date!