"Dermazol" (ointment): instructions, reviews, analogues

Very often the cause of unpleasant odor and itching is the fungus. This is a medical and aesthetic problem, which brings considerable discomfort. It is necessary to walk constantly in closed shoes and stay away from relatives and relatives. Fungal diseases can be quickly cured with the help of special medications. Good results show "Dermazol" (ointment). But the medicine should be administered strictly according to the instructions and only after consultation with the doctor.

Composition of the medicament

"Dermazol" is an antifungal agent for external use. The main active ingredient is ketoconazole. As auxiliary substances propylene glycol, stearyl alcohol, sorbitan stearate, polysorbate, isopropyl myristate, sodium sulfate anhydrous, and also purified water are used. The drug goes on sale in aluminum tubes and special cardboard packages. To keep the ointment longer to maintain its useful properties, keep it standing in the refrigerator.

Ointment "Dermazol" has a fugistatic effect on the skin. The mechanism consists in changing the lipid composition of the membrane of pathogenic microorganisms. They stop multiplying and soon die. The drug is active against microorganisms, which contribute to the development of multi-colored lichen, as well as some dermatomycosis. In addition, the main active ingredient can act against gram-positive cocci.

Pharmacokinetics

Ketoconazole is a fairly weak compound that dissolves rapidly in an acidic environment. The maximum content of the active substance in the plasma is reached only a few hours after the application of the drug "Dermazol". Ointment has a cumulative effect. It is not possible to notice improvements from the first application. The maximum bioavailability of the drug is achieved when it is taken with food in the form of tablets. In patients who have an increased gastric acidity, the absorption of ketoconazole is reduced. Therefore, it may be difficult to correctly determine the dosage of the drug.

The main component binds in the liver after absorption in the gastrointestinal tract. In this case, many inactive metabolites can be formed. The main ways of metabolism is the cleavage of the piperazine ring. Only 15 percent of the drug is excreted in the patient's urine. Not more than 5 percent comes out unchanged. More than 60 percent of ketoconazole is excreted from the body along with the calves.

Indications

Can be used in various cases, "Dermazol" (ointment). Instructions for use say that the drug can be used externally in many diseases. Most often it is used to treat various candidiasis. Often helps to cope with the running form of the foot fungus ointment "Dermazol". What else will the drug save? Ointment is prescribed for the treatment of inguinal epidermophytic, epidermophytosis of hands and feet, pityriasis, seborrhea.

With the help of topical application, you can cure acute vaginal candidiasis or a chronic recurrent form of this disease. Also, the medicine is used for preventive measures. Ointment is applied to the genitals in order to avoid the repeated development of fungal infection. Securing yourself is necessary with reduced resistance of the organism or after a course of treatment with antibacterial agents. It is worth remembering that antibiotics kill not only pathogenic microorganisms, but also useful ones. And as a result, the microflora suffers.

Ointment "Dermazol" may not give the desired effect with topical application. Then the medication is prescribed orally in the form of tablets. Use the drug for such diseases as histoplasmosis, blastomycosis, paracoccidioidomycosis, as well as coccidioidomycosis.

Contraindications

Medication can not be used for individual intolerance of its components. It is necessary to take with care "Dermazol" (ointment) to patients who have chronic liver diseases. The doctor must decide on the use of the drug. Medication in tablet form can not be administered to children under three years of age, as well as to pregnant and lactating women. Dermazol ointment during pregnancy and lactation is allowed.

The drug in the form of tablets is incompatible with many drugs. Using it without first consulting a physician can lead to serious side effects. It is necessary to consult with a dermatologist people who suffer from chronic diseases and are forced to constantly take medication. In rare cases, unpleasant symptoms begin to appear even when using multivitamins in conjunction with Dermazol. Allergic reactions associated with hypersensitivity may occur.

special instructions

Can not be prescribed for fungal meningitis ointment "Dermazol". The use is impractical, since the main active ingredient does not penetrate the blood-brain barrier. Some patients have a high risk of hepatotoxicity. Therefore, the specialist must conduct a number of necessary analyzes, weigh the pros and cons. The drug is prescribed only when the benefit exceeds the potential risk to the patient.

People with increased activity of hepatic enzymes, which appeared against the background of treatment with other medications, should not take Dermazol (ointment). The reviews show that the positive effect under such conditions is almost invisible. In this case, the patient can cause even greater harm to his body. People with liver failure, severe degree of antifungal ointment is generally contraindicated. The specialist must study the liver function of the patient before prescribing the medicine. For this, a number of analyzes are carried out. If the drug is still prescribed, it is necessary to constantly monitor the picture of peripheral blood. This makes it possible to notice the first symptoms of hepatotoxicity in a timely manner and to cancel the Dermazol ointment. You can always choose a more sparing medicine.

If glucocorticosteroids were prescribed for the treatment of skin diseases , then an antifungal ointment can be prescribed not earlier than two weeks after their withdrawal.

Dosage

Can be prescribed only to people who have completed a complete examination of the ointment "Dermazol" from the fungus. The doctors' testimonies indicate that such a preparation can cause harm to children. Therefore, it should be used strictly according to the instructions. The drug is intended for external (ointment) and internal use (tablets). Ingestion is carried out at a dosage of 200-400 mg per day. Children with body weight less than 30 kg dosage is calculated individually and is 5-10 mg per 1 kg of body weight.

External application may depend on the form and extent of the disease. To treat the foot or hair follicle, the drug is applied several times a day to the affected area. You can also make compresses at night for feet. "Dermazol" (ointment) is applied to the nail plate and feet and a gauze bandage is put on. Treatment of fungal diseases is carried out at home. Periodically, you should visit a dermatologist to monitor the course of the disease.

Side effects

People with chronic diseases should use "Dermazol" (ointment) with caution. The instruction describes a number of side effects in which the medication should be stopped. From the nervous system, such untidy symptoms as migraine, dizziness, fatigue, weakness, daytime drowsiness and sleeplessness can be observed. In most cases, such phenomena are observed when using tablets "Dermazol". Sometimes patients may experience an increase in intracranial pressure. In the first place, the discs of the optic nerves swell . Such side effects are reversible and no withdrawal of the drug is required.

With external use, the ointment "Dermazol" can cause irritation, redness of the skin.

Immediately stop taking the medicine if symptoms such as vomiting, impaired liver function are observed. All this can lead to severe hepatotoxicity. The patient may develop cirrhosis or liver failure. Such changes are irreversible.

In some cases, patients may have a metabolic disorder. Patients begin to gain weight quickly or, conversely, refuse to eat. As a result, anorexia develops, which requires additional treatment.

People who are addicted to allergic reactions should also use Dermazol (ointment) with caution. Instructions for use describe the first symptoms of drug intolerance. This is a skin rash and itching. In rare cases, the allergy manifests itself in the form of swelling of the limbs and face. If these symptoms appear, stop taking the medication immediately.

At the initial stage of treatment, patients can also feel chills or fever. Unpleasant symptoms do not indicate changes in the body and cancellation does not require. A few days after the start of therapy, patients feel fine.

Drug Interactions

Do not take antifungal drugs in the form of tablets on the basis of ketoconazole together with antacids. Aluminum hydroxide, as well as proton pump inhibitors, help to reduce the absorption of the main active substance from the gastrointestinal tract. The antifungal activity of Dermazol can be significantly reduced. If you can not avoid medication interaction, you need to adjust the dosage.

Substantially reduce the bioavailability of ketoconazole substances such as rifabutin, carbamazepine, rifampicin, efavirenz, nevirapine. When combined with drugs based on these components, "Dermazol" may be ineffective. Similar preparations should also be used with caution. A good substitute can be chosen only by a doctor.

The development of side effects can provoke the joint use of ketoconazole with such substances as tamsulosin, rifabutin, carbamazepine, salmeterol, nilotinib. If such combinations can not be avoided, it is necessary to constantly monitor the patient's condition. Ideally, it should be treated in a hospital setting.

Ointment "Dermazol" is well combined with other drugs.

Analogues

What if, for a number of reasons, it was not possible to purchase Dermazol (ointment)? Analogs will always be able to pick a doctor. Popular among specialists uses the drug Nizoral, which also works on the basis of ketoconazole. The medicine is available in the form of a cream and goes on sale in aluminum tubes. Cream "Nizoral" is prescribed for such skin diseases as pityriasis, candidiasis, seborrheic dermatitis, dermatomycosis, inguinal epidermophytosis. The medicine has practically no contraindications. It is canceled, as in the case of Dermazol, only if the patient develops a hypersensitivity to any of the components of the drug. Ointment "Nizoral" is allowed for admission during pregnancy and lactation. But treatment should be started only after consulting a doctor.

Cream "Mikospor" - another popular antifungal drug. The main active ingredient is bifonazole. As auxiliary substances, cetostearyl alcohol, polysorbate, sorbitan stearate, cetyl palmitate, and purified water are used. The drug is prescribed for foot mycoses, erythrasis, superficial candidiasis of the skin. Contraindications also include only increased sensitivity to one of the components of the drug.

Thus, all these medicines are not worse than the ointment "Dermazol". Similar preparations perfectly cope with the task.

Reviews about the drug "Dermazol"

Patients who use the drug strictly according to the instructions, respond well to the drug "Dermazol". Patients say that the medicine is really good at curing candidiasis, mycosis. There is also "Dermazol" in the form of a shampoo. Testimonials indicate that this is an excellent remedy for seborrhea of the scalp (dandruff). Of course, the tool is not cheap, but it does help.

The medicine has a cumulative effect. Therefore, changes can not be noticed from the first application. A good result begins to appear on average after a week of therapy. Doctors say that a drug based on ketoconazole works much better on the body if the patient does not simultaneously treat other medications. When appointing tablets and ointment "Dermazol", each specialist specifies the patient's presence of chronic diseases and the need to take any medications.

The drug has many side effects. Therefore it is necessary to use with care "Dermazol" (ointment). Instructions, testimonials - all this is worth studying before the beginning of treatment, before buying the drug in the pharmacy. The doctor will be able to provide all the necessary information.

The drug is dispensed without a prescription. You can find it in almost any pharmacy. Ointment "Dermazol" refers to the average price category. One tube will have to pay about 150 rubles. Essentially, you can save money if you order a medicine via the Internet. In online pharmacies, prices are often 15-20% lower.

The patients' reviews show that the "Dermazol" ointment is even more effective if it is used in conjunction with folk methods. Against fungal diseases of the feet, the broth of celandine helps. A bit of fresh herbs are poured hot water and insist 20-30 minutes. The celandine perfectly fights against mycoses of varying severity. Broth can be wiped affected areas several times a day. Do not forget about the correct medication. Finally forget about the fungus will help ointment "Dermazol".