Anesthetic tablets "Bral": instructions for use, composition, indications

The drug "Bral" instructions for use determines how non-narcotic analgesic and antispasmodic. This is a combination drug that includes the hydrochloride of pituopenone (myotropic antispasmodic), metamizole sodium (non-narcotic analgesic), and fenpiverinia bromide (m-cholinoblocker).

Pharmacotherapeutic group

Metamizole sodium is a derivative of pyrazolone, it exhibits analgesic, insignificant anti-inflammatory, antipyretic activity. Pitophenone hydrochloride with respect to smooth muscles exerts a papaverin-like miotropic relaxing effect. Bromide fenpiverinia has pronounced holinoliticheskimi properties, reduces temperature and painful sensations, removes smooth muscle spasms. The combined use of these three components leads to a mutual increase in their pharmacological effect on the body, an increase in spasmolytic and analgesic effects.

Indications for use

The drug "Bral" instructions for use shows the appointment with a moderate pain syndrome, resulting from a spasm of smooth muscles of the urinary or biliary tract, concomitantly with the development of renal or hepatic colic, postcholecystectomy syndrome (a condition that occurs after removal of the gallbladder), spasms of the intestine or bladder, Algodismenorrhea, dyskinesia of the biliary tract (hyperkinetic type), chronic spastic colitis, inflammation of the pelvic organs. The drug is also used for short-term therapy of acute pathologies of the joints and peripheral nervous system (myalgia, ishialgia, arthralgia, neuralgia). Medication "Bral" instruction for use advises to use as an auxiliary tool to eliminate pain syndrome after diagnostic tests and surgical intervention. The medicine, among other things, is prescribed for fever during inflammatory and colds.

Form of release, packaging, composition

In most cases, the drug "Bral" in the form of tablets is used. They are packaged in blisters / strips of ten and packed in cardboard boxes one, two, ten blisters / strips. Tablets "Brough" composition have the following: in each unit contains such active ingredients as metamizole sodium, pentophenone hydrochloride , fenpiverinium bromide - in an amount of 500, 5 and 0.1 milligrams, respectively.

The drug "Bral" is also available in the form of an injection (for intravenous / intramuscular injection), which is a transparent yellowish liquid. Five ampoules made from hydrolytic dark glass, in each - five milliliters of solution, are placed in a pallet (a cell packaging made of polyvinyl chloride film), which, in turn, is packed in a cardboard box along with the instruction. In one milliliter of the solution contains the active ingredients: metamizole sodium, pentophenone hydrochloride, fenpiverinium bromide - in the amount of 500, 2 and 0.02 milligrams, respectively. In addition to them, the composition includes minor components: hydrochloric acid, water for injection.

The drug "Bral". Instructions for use (tablets, solution)

Tablets should be taken after meals orally, without chewing, washing with water in a small amount. Children from fifteen years old and adults are shown twice or thrice a day to drink one or two tablets (not more than six pieces per day). Until the age of fifteen, it is permitted to use the drug only in the presence of acute indications and according to the doctor's prescription. To small patients at the age of six to eight years, the "Bral" tablets (the instruction indicates this) should be given at half the tablet twice or thrice a day, not longer than five days. Children of nine to twelve years are prescribed two to three times a day for three-quarters of the tablet, adolescents thirteen to fifteen years old - one tablet.

In cases of severe colic, the "Bral" medication instructions for use show parenteral use. Children of fifteen years and adults are slowly injected intravenously slowly (per minute, one milliliter), injecting 2 milliliters of medication at a time (the dose per day should not exceed four milliliters); From twelve to fourteen years - 0.8-1 ml; From eight to eleven - 0,5-0,6 ml; From five to seven - 0.3-0.4 ml; From three to four - 0.2-0.3 ml and from one year to two - 0.1-0.2 ml. Children under one year are contraindicated with intravenous injection, for them intramuscular injections are allowed in the amount of 0.1-0.2 ml at a time. Infants from one to two years intramuscularly injected 0.2-0.3 ml, from three to four - 0.3-0.4 ml, children from five to seven years - 0.4-0.5 ml, from eight to Eleven - 0,6-0,7 ml, from twelve to fifteen - 0,8-1 ml. If necessary, the procedure is repeated after six to eight hours. In one syringe is not allowed to mix the solution "Bral" with other medications. Before the injection, you need to warm the syringe with the medicine in your hand.

Adverse events

When taking the drug in therapeutic doses, its tolerability is good. However, angioedema may develop, allergic reactions in the form of skin itch, rash, in rare cases - hives, anaphylactic shock. Single patients noted the appearance of a burning sensation in epigastrium, headache, dry mouth. Possible occurrence of tachycardia, dizziness, cyanosis, lowering blood pressure. Disturbances of hematopoiesis, thrombocytopenia, leukopenia, agranulocytosis (manifested by unjustified temperature increase, difficulty swallowing, sore throat, stomatitis, in some cases - the phenomena of proctitis or vaginitis) can occur if you take long tablets "Bral". The use of the drug in large doses threatens the impaired functioning of the kidneys: staining with red urine, anuria, oliguria, interstitial nephritis, proteinuria. With a tendency to bronchospasm, taking medication can trigger an attack. In extremely rare cases, the use of the drug develops Stephen-Johnson syndromes (exudative erythema of malignant nature) and Lyell (epidermal necrolysis). Among other things, it is possible (very rare) the appearance of such negative effects as paresis of accommodation, decreased sweating, difficulty urinating. When intramuscular administration of the drug may infiltrate at the injection site.

Contraindications

Analgesic tablets "Bral" can not be given to children under five years of age, injecting the drug intravenously is prohibited in infancy and with a body weight of less than five kilograms. Contraindicated drug under the following conditions and pathologies:

• Hypersensitivity to the components present in the composition, including the derivatives of pyrazolone;
• Oppression of bone marrow hematopoiesis;
• Severe renal / hepatic insufficiency;
• Deficiency of glucose-6-phosphate dehydrogenase;
• Severe angina;
• Tachyarrhythmias;
• Angle-closure glaucoma;
• Decompensated heart failure;
• Intestinal obstruction;
• Hyperplasia of the prostate (in the presence of clinical manifestations);
• Megacolumn, collapse.

It is not recommended to use the drug "Bral" during pregnancy (especially in the first trimester and in the last six weeks) and in the lactation period. Caution should be used medication with a tendency to arterial hypotension, hypersensitivity to NSAIDs, bronchial asthma, acute rhinitis or urticaria caused by the use of acetylsalicylic acid.

Overdose

It is manifested by vomiting, drowsiness, epigastric pain, decreased blood pressure, confusion, convulsions (in rare cases), impaired kidneys and liver. It shows gastric lavage, oral administration of activated carbon and other enterosorbents, symptomatic therapy.

How much does "Bral" cost?

On average, the package of the drug, including ten tablets, will cost you 34-44 rubles, twenty tablets - 50-82 rubles, one hundred tablets - 210-285 rubles. The price of a solution for injections (a package of five ampoules of five milliliters) varies between 62-78 rubles.

special instructions

Before finding out the reason, you can not use a medicine to stop acute pain in the abdomen. During treatment with the drug "Bral" it is forbidden to drink alcohol, you should refrain from performing work that requires a quick mental / physical reaction, driving. Usually, parenteral administration of the drug is prescribed only in emergency situations, when for some reason, oral administration is impossible, for example, if absorption from the digestive tract is impaired. When introducing a solution in the volume of two milliliters, special care is needed, since there is a risk of lowering blood pressure. With intravenous injection, it is necessary to control the frequency of breathing and cardiac contractions. Prolonged use of medicines in the form of tablets causes the need to monitor the liver, the picture of peripheral blood.

Drug Interactions

The drug "Bral" enhances the effect of ethanol. Joint use with phenothiazine derivatives, especially chlorpromazine, can lead to the appearance of severe hyperthermia. It is possible to increase m-cholinoblocking activity with simultaneous administration with butyrofenones, tricyclic antidepressants, quinidine, amantadine, H1-blockers. Allopurinol, oral contraceptives increase the toxicity of the drug. Tranquilizers increase the analgesic effect of metamizole sodium. It is impossible to use along with the drug "Bral" to use radiocontrast agents, penicillins, colloidal blood substitutes. If you share the tablets "Bral" and cyclosporine, the concentration in the blood of the latter will be reduced.