"Losirin": instruction manual, reviews, analogues

To prevent the development of such a dangerous ailment as myocardial infarction, in medicine use drugs based on acetylsalicylic acid. Anti-Aggressive and anti-inflammatory effect has the "Losirin". The instructions for use detail the therapeutic effect, indications and rules for taking the medicine. Before you start the treatment means, you should read the indications and contraindications for the application and be sure to consult a doctor.

"Losirin": composition

The main active ingredient of "Losirin" tablets is acetylsalicylic acid, which is used as the main prevention of strokes and heart attacks.

One tablet contains 75 mg of active substance. Auxiliary components: silicon anhydrous colloidal dioxide, microcrystalline cellulose, stearic acid.

How does it work?

Acetylsalicylic acid refers to non-steroidal anti-inflammatory substances, which exerts antipyretic, analgesic and antiplatelet effect. The main component is characterized by the ability to thin the blood, reduce its coagulability by suppressing the synthesis of thromboxane A2 in platelet aggregation. This has a vasodilator effect (insignificant). The drug "Losirin" reduces the risk of myocardial infarction, stroke of the brain.

In the digestive tract, the drug is absorbed almost completely. The main process occurs in the small intestine. Thanks to the protective coating, it is possible to minimize the negative effect of acetylsalicylic acid on the gastric mucosa. Biotransformiruetsya active component in the liver. In the body, substances quickly bind to blood proteins and are distributed throughout the system. The main way of excretion is the kidneys.

Indications for use

The drug is most often prescribed to patients for the prevention of myocardial infarction (primary and secondary) in angina pectoris. The following cases also apply to the indications:

• Prevention of thrombosis.
• Prevention of obstruction of vessels with emboli - particles that normally should not be in serum.
• Prevention of cerebral stroke by ischemic type.
• Mitral valve prolapse.
• Transient ischemic attack (reduces the risk of occurrence).
• Prevention of the formation of thrombi in deep veins.
• Prevention of infarction in persons at risk.

The causes of stroke and heart attack

Stroke is an ailment in which blood circulation in the vessels of the brain is broken, that is, oxygen and useful substances necessary for its normal functioning cease to flow there. A similar situation occurs with a heart attack, which most often affects the cardiac muscle (myocardium). The main reasons for the development of these pathologies are thrombosis and atherosclerosis. In the case of cerebral stroke, there may be a hemorrhage, which distinguishes the ailment from a heart attack.

The main factors predisposing to the development of cardiovascular disorders include:

• Hypertensive disease (high blood pressure).
• Diabetes.
• Problems with excess weight.
• Atherosclerosis of vessels.
• Incorrect food.
• Regular use of alcohol, smoking.
• Hereditary predisposition.

"Losirin" instructions for use recommends taking to prevent clogging of blood vessels with blood clots. Tablets based on acetylsalicylic acid are considered quite effective.

Mode of application

The tablets are covered with a special coating that helps to "deliver" the active substance to the destination, that is, to the intestine, and thereby reduce the deleterious effect on the stomach. Therefore, when taking medication, chew it is prohibited. The dosage will depend on the diagnosis of the patient.

Patients with suspicions of acute myocardial infarction should take the drug "Losirin" in a dosage of 75 to 300 mg per day to prevent death. The recommended course of treatment is 1 month. As a secondary prevention of heart attack and stroke, tablets are taken as prescribed by a specialist. The daily dose of the drug "Losirin" - 75-300 mg.

To prevent the formation of thrombi after surgery on the vessels prescribe 75-150 mg of "Losirin" per day, or 300 mg every other day. The same amount of active ingredient is needed for patients at risk.

Features of the drug "Losirin"

Acetylsalicylic acid should not be administered to patients under 16 years of age. This can lead to undesirable serious consequences, for example, Ray's syndrome. The pathological condition occurs in many children and adolescents who take drugs based on acetylsalicylic acid. The ailment affects the functionality of the kidneys, causes cerebral edema and inflammatory processes in the liver. The syndrome can be determined by prolonged vomiting, which occurs after taking the drug. This condition is extremely dangerous for the child's organism and requires immediate medical attention.

Appointment of the drug during pregnancy

The agent "Losirin" during pregnancy can appoint only the attending physician in case of emergency. In clinical trials it was found that suppression of prostaglandin synthesis does not adversely affect fetal development and the course of pregnancy as a whole. At the same time, acetylsalicylic acid can not be administered in the first trimester, when the main fetal systems are laid.

In the last trimester of pregnancy, prostaglandin synthesis inhibitors can cause cardiopulmonary toxicity and affect the performance of the kidneys. Acetylsalicylic acid is not prescribed in the last terms of gestation, in order to avoid prolonged bleeding caused by antiplatelet action. There is also a risk of worsening contractile activity of the uterus, which lengthens the process of delivery.

If necessary, the drug is prescribed in a minimal dose and for a short course of therapy.

Special instructions regarding the use of the medicine

With caution should take "Losirin 75" to persons with increased sensitivity to anti-inflammatory and analgetic substances. Acetylsalicylic acid can affect the functionality of the kidneys if a history of the patient has such ailments as kidney failure, the pathological state of the vessels.

Patients who are prone to allergic reactions should take extra care with tablets. The active ingredient is able to cause bronchospasm, hives, itching of the skin.

Even small doses of the drug can affect the rate of excretion of uric acid, which is dangerous for patients with a diagnosis such as gout. The inhibitory effect of the basic substance on the aggregation of platelets persists for several days. Therefore, it is recommended to stop taking the medication before the planned surgical interventions (including before the removal of the tooth) not less than 5 days in order to prevent the development of bleeding.

In the presence of peptic ulcer, acetylsalicylic acid-based tablets can only be prescribed by the attending physician.

Contraindications

"Losirin" medication instructions for use prohibit use if the patient has intolerance or hypersensitivity to components in the formulation. Tablets can not be used to treat patients with thrombocytopenia, hemorrhagic diathesis, hemophilia. Contraindication is also ulcerative pathology of the gastrointestinal tract in the acute stage, renal and hepatic insufficiency, age to 16 years, bronchial asthma.

Interaction with other medicinal products

It is forbidden to simultaneously take acetylsalicylic acid (tablets "Losirin") and methotrexate, if the weekly dose of the latter exceeds 15 mg. It is necessary to avoid simultaneous reception of "Losirin" and anticoagulants, thrombolytic agents. This significantly increases the risk of bleeding.

It is undesirable to apply simultaneously high doses of the drug with non-steroidal anti-inflammatory drugs in order to prevent the development of peptic ulcer diseases of the digestive system and bleeding of the gastrointestinal tract.

Simultaneous use of the drug with digoxin helps to increase the concentration of the drug in the blood serum. The hypoglycemic effect of drugs from the group of sulfonylurea derivatives used for therapy in diabetes mellitus is increasing.

It is not recommended to take valproic acid with the drug "Losirin" in order to avoid increasing the toxic effect on the body of acetylsalicylic acid.

Interaction with alcohol

The drug "Losirin" instruction prohibits combining with alcohol. The components strengthen each other's action, which is a double blow to the mucosa of the digestive tract. In the presence of ulcerative lesion it is quite possible the development of bleeding, which poses a serious danger to the life of the patient.

Preparations based on aspirin can be taken no earlier than 12 hours after taking alcoholic beverages. Otherwise, there may be negative consequences for the body.

Symptoms of drug overdose

An overdose of a drug is most common in the elderly. The main signs of a pathological condition are:

• Dizziness.
• Attacks of nausea and vomiting.
• Confusion of consciousness.
• Noise in ears.
• Acute intoxication.
• Hemorrhage.
• Respiratory failure.
• Decreased acuity of hearing.
• Hypoglycemia.

The toxic effect of the main substance develops as a result of prolonged therapy or exceeding the recommended daily dosage. Moderate intoxication is observed against the background of repeated intake of elevated doses of the drug. If in the blood plasma the concentration of salicylates exceeds 300 μg / ml, there is a possibility of acute intoxication, which is manifested in a change in the acid-base balance.

Patients with symptoms of overdose should be sent as soon as possible to a medical institution where they will purify the body and restore the acid-base and electrolyte balance.

Adverse events

The greatest number of negative effects of taking tablets is observed from the gastrointestinal tract. There may be a pain syndrome in the epigastric region, diarrhea, nausea, erosion and ulcerative lesions of the mucosa.

From the side of the vascular system, there is a risk of developing bleeding from the nasal passages, gums, and gastrointestinal organs. The greatest danger is faced by patients with a risk of cerebral hemorrhage with hypertension. Some patients note the occurrence of headache, ringing in the ears and disturbances in spatial orientation after taking the drug "Losirin".

Instruction for use warns of possible negative reactions from the immune system. With increased sensitivity to the components, a skin reaction may appear in the form of hives, redness, itching.

"Losirin": the price and reviews

Most patients taking the drug are satisfied with the result and mild therapeutic effect. Unlike analogues, its dose is somewhat smaller, which reduces the risk of side effects, for example, noise in the ears, dizziness. It is also worth noting the relative safety of the drug "Losirin". The patients' feedback confirms that, due to the protective coating, there is practically no negative effect on the organs and mucous surface of the digestive system. Dissolve the medicine begins only in the intestine.

"Losirin", the price of which ranges from 90 to 170 rubles. For 30 tablets, is somewhat more accessible than other drugs of the antithrombotic group. The drug has proven itself in the prevention of blood clots, the development of cerebral stroke and myocardial infarction. Applying "Losirin" to the appointment of a specialist and adhering to individual recommendations for treatment, you can avoid negative consequences and side effects.

Than to replace?

The pharmaceutical market offers a huge selection of drugs of a similar effect. The medicinal medicine "Losirin" analogs has the following:

• "Aspirin Cardio" - the most popular means for dilution of blood, prevention of blood clots in the vessels. Can be used for a long time.
• "Aspecard" - a preparation of anti-inflammatory, analgesic and antipyretic action. It is used as an antithrombotic drug.
• "Clopidogrel" is a synthetic antiplatelet drug used to prevent cardiovascular pathologies. The main active ingredient is clopidogrel bisulfate.