Hormone estradiol: the norm in women. Estradiol: the norm during pregnancy

The human body is a complex system, the functioning of which is influenced by hormones. These biologically active substances are produced by cells of endocrine glands. They enter the bloodstream and affect the metabolic processes and functions of internal organs. The lack of these compounds can lead to disruption of the work of various body systems. The sex hormone estradiol is considered the most important for reproductive function . The norm in women of this substance not only guarantees the reproduction of healthy offspring, but also shapes their appearance.

What is estradiol?

This is one of the most important sex hormones, which belongs to the group of estrogens. Under his influence, the entire sexual system and internal organs responsible for reproductive function are formed in women. In addition, this active substance is responsible for the rounded outline of the figure in the fair sex, breast growth, controls the deposition of subcutaneous fat on the abdomen and thighs. The hormone affects the level of sexual desire and temperament of the ladies, regulates the menstrual cycle.

What properties does

The hormone estradiol in women is able to increase blood flow in the uterus, positively affect the condition of the vessels. The active substance has:

• Anabolic action.
• Accelerates the maturation of the egg.
• Strengthens metabolic processes in bone tissues.
• Retains water and sodium in the body.
• Reduces cholesterol.
• Increases blood clotting.

Estradiol promotes the release of neurotransmitters, which reduce irritability and prevent nervous overexcitation. Excellent skin condition, lack of wrinkles, shine in the eyes, fervor and enthusiasm, physical endurance - all these signs provide a normal level of estradiol in the blood. The highest value of the hormone is observed between 15-18 hours, and the smallest release occurs from 24 hours to 2 hours.

The hormone in the female body

The concentration of estradiol in the blood can fluctuate depending on the physical condition of the woman and during the entire menstrual cycle. In a healthy woman's body, the sex hormone level should be lowered during the follicular phase of the cycle. Approximately 3-6 days before the increase in the hormone of the pituitary (LH), the level of estradiol begins to rise, the rate of which rises sharply and reaches its maximum one hour before the LH peak.

Literally a couple of days after the maximum concentration of luteinizing hormone, the index of estradiol begins to drop sharply, then again it gradually rises. Achieves the next maximum value on the 9th day after ovulation. But if the pregnancy has not occurred, the level of the active substance begins to decrease and reaches the required norm.

Laboratory indicators

It is very important for each girl to conduct periodic studies of the level of the major hormones. The emergence of many diseases, disruption of the internal organs and improper functioning of the reproductive system - all these problems can cause an increased or decreased hormone estradiol. The norm in women who do not bear a child is:

• The follicular phase - the indices range from 57 to 227 pmol / L in blood plasma.
• The preovulatory peak is 127 to 476 pmol / l.
• The luteal phase is the norm from 77 to 227 pmol / l.

It should be noted that in women aged (with menopause), these rates are much lower.

The main hormone of pregnancy

As doctors say, with a reduced level of estradiol it is impossible to bear a child. After all, during this period the hormone must be present in the body in the maximum amount: the correct formation of the placenta depends on it, it promotes the development and growth of the uterus, normalizes blood circulation in the pelvic organs. In addition, he is responsible for the normal blood clotting during childbirth, providing a minimal risk of bleeding. But the low rates of this biological substance can lead to miscarriage, especially in the early term. So, the hormone estradiol - the norm in pregnancy is:

• 3-6 weeks - 0.5-4.0.
• 7-8 - 4.0-7.5.
• 9-10 - 7.5-8.5.
• 11-12 - 8,5-10,9.
• 13-14 - 10.5-12.0.
• 15-16 - 12.0-21.5.
• 17-18 - 21.5-29.0.
• 19-20 - 29.0-37.0.
• 21-22 to 37.0-38.0.
• 23-24 - 38.0-42.0.
• 25-26 - 42.0-45.0.
• 27-28 - 45.0-50.0.
• 29-30 - 50.0-52.0.
• 31-32-52.0-55.0.
• 33-34-55.0-57.2.
• 35-36-57.5-59.0.
• 37-38-59.0-61.0.
• 39-41-61.0-66.0.

Doctors recommend constantly monitoring the level of the hormone throughout pregnancy.

How to pass the test correctly

As doctors say, the second most important substance of the estrogen group for women in the position is the hormone estradiol. The pregnancy rate of this substance should be established under the following rules:

• Normal emotional state - the analysis is not allowed in a state of nervous overexertion or increased excitability.
• You can not drink alcohol and smoke.
• One day before the study, exclude physical activity and sex.
• The analysis is performed on an empty stomach, in the morning and before lunch.

Observing these rules, you can get the exact result of the analysis, but if you did not fulfill the requirements or took any medications, you need to inform the doctor about it.

What determines the level of the hormone in the blood

It is very important to know why the active substance increases its concentration in the blood. Such indicators indicate the presence of the following factors:

• Persistence of the follicle.
• Cysts in the ovaries of the endometrioid nature.
• Various tumors of the ovaries.
• Cirrhosis of the liver.
• Taking drugs phenytoin, ketoconazole, mifepristone, nafarelin, estrogens.

Estradiol lower than normal in women can be due to the following reasons:

• Hypogonadism.
• Pituitary Nanism.
• Hyperprolactinemia.
• Insufficiency of the luteal phase.
• Viral Syndrome.
• Syndrome Shereshevsky-Turner.
• Chronic inflammation in the internal genital organs.
• Risk of miscarriage.
• Smoking of pregnant women.

In some cases, the concentration of the hormone falls as a result of increased physical activity, a sharp loss of weight, with no fat in the diet, vegetarianism. Signs of a decreased level of estradiol include dry skin, irregular menstrual cycle or complete absence, long-term pregnancy, breast reduction. Therefore, it is important to monitor the hormone estradiol when planning pregnancy. The norm in women of this substance will provide not only a successful conception, but also significantly increase the likelihood of successful gestation and mild birth in a future mother.

Medication

If, as a result of the examination, a reduced level of estradiol is established, the doctor may prescribe medications that contain this substance. They not only help to restore the normal menstrual cycle, but are also shown in polycystic ovaries, vaginitis, infertility, with ancestral weakness, with a delayed pregnancy, for suppressing lactation after childbirth, with viral hypertrichosis. Such medicines are produced in various forms: tablets, transdermal gels, intramuscular solutions, nasal sprays, transdermal therapeutic systems. Remember, only the attending physician can prescribe an adequate treatment! Depending on the individual characteristics of the body use:

• Pills "Estrofem."
• Proginova gel.
• Solution for injection "Estraderm TTS 25".
• Gel "Estradiol".

After a thorough gynecological examination, therapy is prescribed, it lasts a rather long time. Such treatment allows you to increase the hormone estradiol in the body. The norm in women of this substance is the main condition both for the normal functioning of the reproductive system and for the onset of pregnancy.