Analog "Trental" in ampoules. Trental: indications for use, instructions

Throughout the life of modern man, various hazards lie in wait. Among them, not the smallest part is occupied by diseases of different directions, intensity and complexity. And the mortality rate associated with diseases of the cardiovascular system, in general, occupies one of the leading positions in the world.

However, modern science does not stand still. Scientists-biochemists have already developed and continue to work on obtaining new medications that help a person to overcome in the fight against heart and vascular diseases. One of the groups of such medicines, which are important for complex treatment, are angioprotectors. Drugs of this group are characterized by high activity with respect to the removal of spasms and promote vasodilation, improvement of microcirculation, normal rheological properties of blood and vascular permeability. The use of angioprotective medications helps to reduce edema of tissues and activate metabolic processes. Widespread use of this group of drugs was found in the treatment of various kinds of angiopathy - diabetic, rheumatic and rheumatoid, atherosclerosis, vein problems (varicose enlargement, congestion and inflammation), trophic ulcers and other similar pathologies.

Most often to combat such problems, medical staff appoint "Trental" (medicinal analogs, by the way, are much more affordable).

Component composition and manufacturing forms

The main active substance of Trental is pentoxifylline. Consumers are offered this medication in three forms: in tablets (each containing 100 or 400 mg of pentoxifylline) and in the form of a solution for injections in ampoules of 5 ml (1 ml - 20 mg of the active ingredient). Accordingly, for a full replacement, the Trental analog should be designed specifically on the basis of pentoxifylline and in the same dosages (100 and 400 mg).

Pharmacodynamics of angioprotectants

Pentoxifylline (the main component of Trental) improves the rheological properties of blood, which becomes less viscous and thick. In addition, this substance prevents excessive synthesis of platelets, contributes to the expansion of blood vessels. As a consequence, the microcirculation of biological fluid in tissues qualitatively improves (in the brain including), it is possible to prevent thrombosis and vascular sclerotia with a high probability.

For example, Trental 400 (analogues of it to the same extent) improves microcirculation in those areas where blood circulation is disturbed. It exerts a miotropic vasodilating action on the human body (though weak, but it does), contributes to an insignificant expansion of the coronary vessels. Complex therapy with the use of this drug significantly improves the picture of cerebral circulation disorders. If the patient suffers any occlusive lesions of the peripheral arteries (for example, lameness), then the success of the treatment can be expressed in increasing the distance when walking, the disappearance of cramps in the calf muscles during the night period and the absence of pain at rest.

Indications for use

Medication "Trental" indications for use (analogues are close in terms of the effect on the body) is quite diverse. First, these are circulatory disorders. The drug is taken to eliminate the consequences of cerebral atherosclerosis (dizziness, memory impairment, inability to concentrate attention), IHD and post-stroke states.

To apply "Trental", analogues of the drug is indicated for circulatory disorders in peripheral arteries that are of an atherosclerotic nature, with trophic deviations (trophic ulcers, gangrenes). It is justified and effective to use the medication for violations of the eye blood circulation, atherosclerosis, changes with signs of degeneration that occur in the pathologies of the vessels of the inner ear and reduce auditory perception.

This drug is also shown in pathologies of the spinal column, which include such injuries as cerebrospinal stroke, atherosclerosis of the spine vessels, radiculitis, osteochondrosis, fractures and pronounced bruises of the spine, Bekhterev's disease.

Whom is the use of angioprotectors contraindicated?

Any angioprotectant - the analogue of Trental (as, indeed, Trental itself) - can not be taken to patients with a pronounced hypersensitivity to pentoxifylline, other methylxanthines (pentoxifylline-xanthine derivative) or any excipient that is present in the taken form of the release (tablets, injections ). It is inadmissible to use this group of medicines for massive bleeding of any origin (pentoxifylline reduces the viscosity of the blood), bleeding in the retina of the eye, into the brain, in a state of acute myocardial infarction and heart failure. Contraindication is the presence of the patient's hypotension (low blood pressure), renal and hepatic insufficiency, ulcerative lesions of the stomach and duodenum. In the case of surgical interventions, Trental and its analogs are not prescribed earlier than a week after the operation.

Contra "Trental" (analogues too) for children and adolescents under 18 years, pregnant women and nursing mothers.

Possible side effects of angioprotecting

For any angioprotectants (Trental, analogs), the instructions for use describe possible side effects that are infrequent, but do happen. From the gastrointestinal tract, there may be pain in the abdomen, nausea, vomiting, constipation, diarrhea, or alternation of these conditions.

The cardiovascular system can remind of itself attacks of a stenocardia (compressing pain behind a breast bone, having short-term character), a tachycardia, a hypotension (depression of arterial pressure). Allergic reactions are possible in the form of pruritus, dizziness and headaches, Quincke's edema, anaphylactic shock. In addition, Trental, analogs (consumer reviews report this) sometimes cause reactions in the form of sleep-wakefulness disorders, increased nervousness, convulsions, and visual impairment.

If the above symptoms have appeared, the use of Trental should be stopped, seek medical help, and wash the stomach. If necessary, use symptomatic drugs.

If adequate measures are not taken to normalize the situation, the following symptoms are likely to occur:

- nausea and vomiting "coffee grounds" (a sign that gastric bleeding is developing);

- further decrease in blood pressure;

- Increased dizziness;

- the appearance of syncope;

- convulsions;

- fever.

With the development of such symptoms it is necessary to rinse the stomach, take medications for symptomatic treatment and do not forget about the need to use absorbents in such cases.

Excess of the permissible dose: consequences, measures for their elimination

"Trental" is a fairly aggressive medical product, and an overdose can be fraught with serious consequences. Symptoms that indicate the administration of a large dose of medication are dizziness, nausea, hypotension (falling blood pressure), tachycardia (increased heart rate), arrhythmia (heart rhythm disturbance), redness of the skin, loss of consciousness, convulsions, chills. If there is a suspicion of an overdose, Trental should stop taking it and seek qualified medical help. Treatment in this case is focused on maintaining blood pressure and respiratory function at the proper level. If convulsive seizures are present, diazepam is used to remove them.

At the appearance of the very first symptoms of excess dose (nausea, sweating, cyanosis), it is necessary to ensure a lower position of the head and upper body. Particular attention should be paid to the patency of the respiratory tract.

Analogues of "Trental" in tablets

If you choose the best analogue of "Trental" in tablets, then the opinions of many specialists and patients will converge on the "Agapurin" medication. The place of its release is Slovakia, but, despite its import origin, at a price it is available to a wide section of the population with very different income levels. "Agapurin" is produced in three dosages - 100, 400 and 600 mg of active substance.

Also known is the drug "Retard", which is an analogue of "Trental". Interestingly, this drug is also available in a dosage of 600 mg of the active ingredient. A medication with such a dose of pentoxifylline can effectively and productively fight very complex diseases associated with circulatory disorders. "Retard" medical workers are usually prescribed for diabetic angiopathy, atherosclerosis of the brain vessels, with functional hearing impairments provoked by vascular diseases. A positive result with the help of Retard can be achieved with transient ischemic attacks, during the recovery from myocardial infarction, in the fight against cerebrovascular disorders and Raynaud's disease. This analogue of "Trental" is effective in tablets and in conditions of acute and chronic insufficiency of blood supply in the retina and the shell of the eye.

There are analogues of "Trental" and in other dosages of the main active substance. 200 and 400 mg of pentoxifylline contain medicines such as Trenpental, Pentamon, Pentylin and Pentylin Fort, Pentomer, Pentohexal, Vazonit, Flexitale. The list can be continued.

However, the cheapest analogue of Trental is, without a doubt, Pentoxifylline. The form of the release, when it comes to tablets, is 200 and 400 mg of pentoxifylline. About this medication you need to know that, in addition to the side effects peculiar to Trental, this drug can provoke aseptic meningitis, paresthesia, tremor, hallucinations, cholestatic hepatitis. Also, in some patients after taking "Pentoxifylline" dry throat, thirst, lacrimation, deviations or changes in taste sensations may appear. Consumers rarely, but can complain about the appearance of conjunctivitis, laryngitis, pain in the ears. In addition, this Russian analogue of "Trental" is capable of provoking the appearance of anemia, bleeding of varying intensity from skin vessels, toxic epidermal necrolysis.

Trental Analogs for Injection

In especially severe cases, when there is a need for injections, health workers usually prefer drugs such as Pentylin, Latren (a form for infusions), Agapurin, Pentoxifylline. Bioavailability of all these medicines tends to 98%. "Agapurin" - an analog of "Trental" in ampoules - is usually used in the most severe cases of cerebral circulation disorders, with angiopathies of diabetic origin. Another area of application of "Agapurin" injections is the rehabilitation of patients who underwent a heart attack, stroke, ischemic attack.

It is often used "Pentylin", which is also an analogue of "Trental". Experts believe that in this preparation the ideal ratio of price and quality.

Demand for consumers is used by the solution for infusions "Latren". The drug is available in three dosages - 100, 200 and 400 mg. In addition to the side effects peculiar to Trental, it can provoke the development of leukopenia, thrombocytopenia, pancytopenia.

In general, if you want to select the Trental analog for injections or infusions, the trend may be the following: first Pentoxifylline as the owner of the most favorable price, then Pentilin, then Latren as the drug with the widest spectrum of effects on the human body . All these analogues are more cost-effective than Trental itself, and they have the same bioavailability as Trental, and sometimes even higher.

Dosing regimens of Trental and its analogues

The tabletted form of "Trental" is taken orally, without chewing and not breaking. Do this after eating 2-3 times a day. Dosage - depending on the instructions of the attending physician - can range from 100 to 400 mg. 1200 mg is the maximum daily dose of the drug. The treatment regimen for each individual patient is developed individually, the course of treatment can last from 2 weeks to several months.

The injections of the drug "Trental" (analogues in this case can be used according to a different scheme) should be administered intravenously, by jet or by drip. In the first case (jet), 1 ampoule of medication is administered for at least 5 minutes. The procedure is carried out 1-2 times during the day.

In order to prepare a dropper, the drug in a volume of 1 to 6 ampoules is mixed with saline or 5 percent glucose. The period of administration of this mixture is up to 1 hour. Put the droppers also 1-2 times during the day. Maximum within a day by drip, it is permissible to administer up to 1200 mg of medicament (up to 12 ampoules).

Angioprotector "Latren" - the analogue of "Trental" with the widest spectrum of action - is used for treatment according to its own scheme. Most often used for intravenous administration. The course of treatment for each individual patient is developed by a qualified doctor, taking into account the body weight of a person and the severity of his condition. The bottle "Latrena" (200 ml) is intended for drip in a vein for 1.5-3 hours. If there are no side effects, you can increase the dosage to 400-500 ml of the drug.

In addition, this analogue of the drug "Trental" is acceptable for children under 12 years. In this case, the minimum effective dose is calculated per kilogram of the child's body weight. Most often, children are prescribed to take 5 mg of medicament per kilogram of weight.

Opinions about "Trental" and its analogues of patients and health workers

Like any analogue of Trental, the drug itself is effective in case of serious diseases and pathologies in the circulatory system. However, the side effects of such drugs are many. A sufficient number of patients took angioprotectors (and Trental, among others) during the rehabilitation period after the infarctions and strokes. In most cases, the drug has confirmed its characteristics of a high-quality drug. Although sometimes there were reviews of noise in the ears, the drop in blood pressure.

A separate group of patients "Trental" was prescribed for the treatment of deafness. Most of the reviews of such consumers had a positive trend.

In contraindications to the drug - pregnancy and lactation. However, quite often gynecologists prescribe this drug to pregnant women to improve blood circulation and nutrition of tissues. A separate group of such patients was instructed to take Trental for preventive purposes.

In general, if Trental (as, indeed, any of its analogues) will be appointed a qualified medical worker and he will also develop a treatment regimen, the risk of side effects will be minimized, and the drug will manifest itself as effectively as possible.