Analog "Flucostat" (cheaper). Tablets "Fluconazole" - reviews, prices

Humanity has existed on the planet for several millennia. Throughout this time, along with people live and successfully evolve a variety of microorganisms. Many of them are necessary for the person to struggle with different external aggressive factors. But there are some who, under certain conditions, can cause disease. It is to such can be attributed various kinds of fungal microorganisms, which constantly threaten human health. To combat them, scientists have been developing antifungal drugs for many years .

Perhaps, the leading position among a large list of such drugs is the drug Flukostat. However, it is not cheap and therefore not accessible to all segments of the population. Much more widespread is the drug "Fluconazole" - an analogue of "Flucostat". Cheaper (15-30 rubles against 170-300), with a wide range of effects, this drug is in no way inferior to that analogue of which is.

What is fluconazole?

Actually, fluconazole, the main active ingredient in the preparation Flucostat, is a potent inhibitor (a substance capable of inhibiting or completely stopping any physiological processes) of the formation of sterols in mushroom cells. This substance is able to withstand the bulk of the pathogens of opportunistic mycoses (opportunistic diseases can be caused by conditionally pathogenic microorganisms, which are usually safe for a person with a healthy immune system). In addition, treatment with "Fluconazole" is effective in identifying fungal microorganisms that are characteristic of a particular locality (endemic mycoses).

Action on the human body

After getting into the body, the drug is absorbed perfectly. Simultaneous food intake has no effect on the course of this process. After taking the capsule, "Fluconazole" quickly penetrates almost all body fluids. The indices of its concentration in plasma of blood, saliva and sputum are close to each other. In patients with fungal form of meningitis, the level of fluconazole in the cerebrospinal fluid reaches 80% of that index in the plasma. The drug is excreted from the human body mainly by the kidneys. During the research, about 80% of the administered dose of the drug is unchanged in urine.

Indications for use

The drug "Fluconazole" instructions for use (the price depends on the form of release: tablets, capsules, powders for the preparation of oral suspensions, syrups, solutions for intravenous injections) recommends taking a fairly wide range of fungal infections that occur in the human body. The list of diseases includes cryptococcal meningitis (a brain tissue disease caused by a fungus), which can have very serious consequences for a person. Also this analogue of "Flucostat" from thrush (vaginal candidiasis) and in any systemic forms of candidiasis is effective.

Specialists prescribe the drug to patients with reduced immunity for preventive purposes. Also, the drug "Fluconazole" is prescribed to those who have had fungal infections after a rather aggressive course of treatment of malignant neoplasms (radiation therapy, cytostatic drugs). Antibiotic therapy is also capable of causing fungal diseases, which must be disposed of in any case.

The use of the drug after performing organ transplantation operations is shown. Therapeutic course of therapy with the use of immunosuppressants can also cause the need to take this effective analogue of "Flucostat", the reviews of which are rather ambiguous.

All kinds of mycosis of the body, skin (including foot mycoses), groin area, onychomycosis (fungal nail lesions), pityriasis (multi-colored long - term or chronic fungal infection of the epidermis) are also the sphere of influence of the drug Fluconazole. People with normal immunity are prescribed for the preparation of deep epidemic mycoses.

Treatment is recommended to begin immediately, without waiting for the results of research and crops. However, when these results are obtained, therapy needs to be adjusted. Treatment should be continued until the complete cure is confirmed by laboratory and clinical studies and analyzes. Premature termination of the treatment course will most likely lead to a relapse of the fungal infection. In this case, most likely, an increase in the dose of drugs and a temporary lengthening of the treatment period will be required, since microorganisms will acquire a kind of resistance (immunity) to the active substance of Fluconazole.

Contraindications: who should refrain from taking

The drug "Fluconazole" instructions for use (price, relatively small, in this case is not an indicator of effectiveness) does not regulate people who suffer from individual intolerance of its main components. You should not use this drug to treat fungal infections for those who suffer from allergic reactions in any form to clotrimazole, miconazole, ketoconazole, econazole, terconazole, sulconazole, sertaconazole. It is inadmissible simultaneous use of preparations "Fluconazole" and "Cisapride" ("Propulside").

Be sure to inform the doctor who prescribes the reception about the problems with the kidneys, liver, heart problems, history of the QT prolonged interval in one's own family or in the family (electrical disturbances in the heart, they can lead to a sudden Loss of consciousness and cause death).

The drug "Fluconazole" and pregnancy - this is generally a separate conversation. Gynecologists believe that a single application of a single dose (up to 150 mg) will not harm the baby. A systemic treatment with this drug can cause the development of congenital disorders in the child.

According to studies, the use of large doses (400-800 mg per day) for a long period during pregnancy led to the fact that children often developed rare congenital abnormalities: brachycephaly, malformation of the cranial vault, "wolf mouth", congenital heart defects. If a woman becomes pregnant during the treatment (capsule or pill) of "Fluconazole", the doctor must necessarily inform her that there is a risk for the baby. And if the future mother decided that the child should be born, then the medical specialists should carefully monitor the pregnancy.

In general, gynecologists recommend to women, who are under treatment for fungal infections, to use effective contraceptives throughout the treatment period.

Also this analogue of "Flucostat" - the Russian preparation "Flukanozol" - can not be taken to children under the age of 4 years.

The drug "Fluconazole" and vaginal candidiasis

Vaginal candidiasis (thrush) is caused by yeast-like Candida fungus. This fungus is present in the body of a woman always and normally can not cause disease. However, if for some reason local or general immunity weakens, the amount of beneficial bacteria in the intestine and vagina of a woman may decrease. Here and activate Candida.

The thrust for thrush development can be a number of reasons. This can be a normal vitamin deficiency or a lack of female sex hormones, malnutrition or persistent stress and fatigue. Provocative factors may be a sedentary lifestyle, wearing synthetic tight linen or clothing, the use of hormonal drugs for contraception, or the effects of antibiotic treatment. And yet, no matter how strange it may seem, the drug "Fluconazole" from thrush will have to be taken to those women who abuse douches or in excess quantities use a variety of antibacterial drugs for genital care. In this case, along with pathogenic microorganisms, the entire useful flora of the vagina also perishes.

Symptoms of thrush development in women include the appearance of cheesy discharge, burning and itching in the genital area, swelling and redness of the genitals, soreness with urination. Unpleasant feelings cause sex. However, these symptoms can be present in other diseases of the female sexual sphere. Therefore, before taking the drug Fluconazole from thrush, you need to visit a gynecologist, undergo a comprehensive examination and make sure that this is a vaginal candidiasis, and not something else that requires a different treatment regimen and other drugs.

Today, the pharmaceutical industry produces drugs in a large range that are able to withstand thrush. However, the main active ingredient in most of them is fluconazole. This analogue of "Flucostat" is cheaper and more affordable for a wide range of consumers for the simple reason that it is released in Russia by the domestic manufacturer.

Taking the drug with thrush

The scheme for using Fluconazole is quite simple. If the disease manifested itself for the first time, and the woman quickly turned to the gynecologist, then a single dose of 150 mg will be sufficient to obtain a positive therapeutic effect and complete cure. In order to consolidate the result, after a few days you can take another pill or capsule. According to the same scheme, the drug "Flucostat" is also taken. The analogue "Fluconazole" simply costs less, but it does not affect its effectiveness in any way.

However, if a woman develops a chronic form of thrush, and there are now about 5% of such patients, the scheme of application of "Fluconaloz" is radically changed. Chronic vaginal candidiasis is difficult to treat, prolonged for a long time, relapses occur easily. In such cases, a single admission is not enough, and the doctor prescribes longer courses of treatment. Usually the drug is taken twice a week for 2 weeks. Further within half a year it is necessary to take a preparation (capsules or tablets) "Flukonazol" once a month in a total dose of 150 mg.

In general, the choice of the regimen for the treatment of vaginal candidiasis remains the prerogative of the attending physician. It is the doctor who will need to assess the severity of the woman's condition, the prescription of the first symptoms, the presence of concomitant health problems (often thrush is just one of the sexually transmitted infections). After analyzing all these factors and their combined effect on the woman's body, the doctor will be able to select the most effective treatment regimen using this particular Flukostat analogue from thrush (the price in this case is not of decisive importance).

Possible side effects

In general, the drug "Fluconazole" is tolerated well in any application (both intravenous and oral). Sometimes it is possible to observe changes in the functioning of the liver and kidneys, but most often this reaction to the drug occurs in patients suffering from serious underlying diseases, such as AIDS and malignant tumors.

In women who took a single dose of 150 mg for the treatment of infections of the genital area, it is sometimes possible to observe such side effects as abdominal pain, nausea, or headaches. The intensity of manifestation is usually expressed weakly or moderately.

From the side of the nervous system, sometimes such manifestations as convulsions, dizziness, problems with sleep, tremor. The gastrointestinal tract can respond to taking the medicine with nausea, diarrhea, vomiting, a violation of taste sensations, and lack of appetite. The response of the liver to the drug is also quite ambiguous. If the patient does not have severe underlying illnesses, the device can provoke temporary disturbances in her work, which stop when the drug is withdrawn. If the patient has difficult and severe underlying diseases (which are also treated with various drugs), this analogue of "Flucostat" (a cheaper antifungal drug or more expensive, it is not important, because the main active ingredient is fluconazole) can sometimes provoke liver problems such as hepatitis, Cholestasis or liver failure, which in some cases can cause death. However, one can not say with certainty that such severe consequences are caused precisely by an antifungal drug, because the underlying disease is also treated with complex medications.

Specialists-dermatologists note that the preparation "Fluconazole" in rare cases can cause rashes on the skin and hair loss (usually in those who take the drug for more than two months). After discontinuation of reception these unpleasant phenomena disappear.

Exceeding the permissible dose: consequences

The use of high doses of the drug "Fluconazole" without the doctor's instructions (price, reviews in this case may be of decisive importance) may lead to its overdose. The most common symptoms that indicate a serious excess of the dose are usually disorders in the functioning of the gastrointestinal tract (nausea, vomiting, diarrhea). In severe cases, cramps may appear. If all these symptoms are present against the background of the medication, the drug should be discontinued. If after this manifestations of an overdose did not stop, you should see a doctor.

Treatment in this case is aimed at reducing the absorption of medication. If after taking the drug did not take more than three to four hours, it will be effective to wash the stomach, and then intake of activated charcoal. If more time has passed, the treatment is carried out permanently, where hemodialysis (purification of blood outside the kidneys), forced diuresis (intake of diuretics), symptomatic treatment is used.

Patients' opinion about the drug

The opinion of the patients taking the drug "Fluconazole" is rather ambiguous. A separate group of patients is very pleased with the results of the treatment. If the disease is not started, the effect manifests itself quickly, and, as a rule, it is quite enough to take one dose of 150 mg. Yes, and finance, this drug overprays not much, given that within 250 rubles is a capsule of the drug Fliukostat. The price (analogues contain the same active ingredient) capsules "Fluconazole" pleasantly surprises - from 15 to 30 rubles (for 150 mg).

However, there is a group of consumers who react negatively to the drug. Usually such reviews are associated with the manifestation of side effects of varying severity. Someone had skin rashes, accompanied by severe itching, which for a long time did not pass. Some patients undergoing treatment for thrush, complained of disorders in the work of the gastrointestinal tract. A small percentage of patients simply did not help the drug. Probably, people developed resistance (immunity, resistance) to the active substance.

Decisive opinion

The modern pharmaceutical market is so wide and diverse that only a competent and experienced physician is able to understand its branches and subtleties. And it concerns this any field of medicine, be it cardiology or neurology, psychiatry or nephrology, therapy or dentistry. Incorrect lifestyle and nutrition, poor ecology and the treatment of any diseases to which the human body is exposed, complex modern preparations can provoke the appearance of fungal infections. And here the decisive word should remain with the attending physician, prescribe for the treatment of fungal infection the drug "Fluconazole" (an analog of "Flucostat", cheaper, but no less effective) or pay attention to other medicinal antifungal agents.