"Vilprafen 1000": instructions, analogues, reviews

What is the preparation "Vilprafen 1000"? The answer to this difficult medical question you will find in the materials of the presented article. Also from it you will learn how to take this medication, what it is meant for, whether there are side reactions and contraindications, what can be replaced and so on.

Composition, packaging and form of release of a medical device

The drug "Vilprafen 1000" can be purchased in a pharmacy in the form of white tablets dispersible tablets (they can be with a yellowish tinge). They have an oblong shape with a risk and the inscription "IOSA" on one side, with the number "1000" on the other. It should also be noted that this remedy has a sweetish flavor and strawberry flavor.

Active substance of the preparation "Vilprafen 1000" is josamycin. As for the auxiliary components, they include aspartame, giprolose, silicon colloidal dioxide, microcrystalline cellulose, sodium docusate, strawberry flavor and magnesium stearate.

In the sale of the drug comes in blisters of 5 tablets, placed in a cardboard box.

Pharmacological action of the drug

What is the medicine "Vilprafen 1000"? Instructions for use of this medication contain information that the drug is an antibiotic belonging to the macrolide group.

The mechanism of action of the drug in question is associated with a violation of protein synthesis in microbial cells. This effect is due to the reversible binding of the active substance to the 50S subunit of the ribosome.

In therapeutic volumes, this agent can have a bacteriostatic effect, slowing the reproduction and growth of bacteria. If you create high concentrations in the inflammation focus, then a bactericidal effect is possible.

The medication "Vilprafen 1000" is especially active against gram-positive and gram-negative microorganisms. However, it does not affect enterobacteria. In connection with this, this drug can not negatively affect the state of the gastrointestinal microflora.

In some cases, the drug remains active with resistance to erythromycin, as well as other macrolides.

Pharmacokinetics of the drug

How long is the drug "Vilprafen 1000" absorbed? The instruction of this remedy states that after ingestion the active element of the drug is absorbed rather quickly from the organs of the digestive tract. At the same time, food intake does not affect its bioavailability.

The greatest concentration of the drug is reached about an hour after ingestion. At a dosage of 1 g, the maximum concentration is about 2-3 μg / ml.

The active substance of the drug is fairly well distributed to tissues and internal organs (with the exception of the brain). At the same time, the medicine creates concentrations that exceed plasma concentrations and persist for a long time at the therapeutic level.

High concentrations of josamycin are observed in the tonsils, lungs, saliva, tears and sweat. The medicine easily passes through the placental barrier, and is also secreted in breast milk.

Jozamycin (the active substance of the drug) is metabolized in the liver. At the same time, active metabolites are formed.

The drug is excreted mainly with bile. But excretion together with urine does not exceed 10%.

Indications for use of a medical device

In what cases should the preparation "Vilprafen 1000" be used? Reviews about this drug, we will consider later. Now I want to tell you that this medicine is prescribed only for infectious and inflammatory diseases that were caused by microorganisms that are sensitive to the drug:

• Diphtheria (as an adjunct to diphtheria antitoxin therapy);
• Infections of the ENT organs and upper respiratory tract (laryngitis, pharyngitis, otitis media, tonsillitis, sinusitis and paratonzillitis);
• Infections of the lower respiratory tract (exacerbation of chronic bronchitis, acute bronchitis, community-acquired pneumonia);
• Pertussis;
• Scarlet fever (if there is hypersensitivity to penicillin);
• Infections of the oral cavity (pericoronitis, gingivitis, alveolitis, periodontitis, alveolar abscess);
• Psittacosis;
• Infections of soft tissues and skin (furuncle, folliculitis, acne, furunculosis, lymphangitis, abscess, phlegmon, lymphadenitis, panaritium, wound, burn and postoperative infections);
• Infections of the eyes (dacryocystitis and blepharitis);
• Erysipelas (if hypersensitivity to penicillin is present);
• Anthrax;
• Infections of genital organs and urinary tract (cervicitis, urethritis, prostatitis, epididymitis);
• Lymphogranuloma venereal ;
• Diseases of the digestive system that are associated with Helicobacter pylori;
• Syphilis and gonorrhea (if there is hypersensitivity to penicillin).

Contraindications to the use of medicament

In what cases is it impossible to use the preparation "Vilprafen Solutab 1000"? Experts say that this medication has the following contraindications:

• Children with a small body weight (less than 10 kg);
• Severe liver disorders;
• Hypersensitivity to the active substance;
• Increased sensitivity to antibiotic drugs belonging to the group of macrolides.

Medicinal preparation "Vilprafen 1000": instructions for use of the drug

Dosage of this drug should be determined only by the attending physician and only on an individual basis.

For adults and adolescents older than 14 years, the usual amount of this drug is 1-2 g. It is recommended to take it in 2-3 sessions. If necessary, the dose may be increased (eg, up to 3 g per day).

The daily dose for children, whose body weight is at least 10 kg, is prescribed based on a calculation of 40-50 mg per kg of weight. The medication should be taken 2-3 times a day.

Based on the foregoing, it is not difficult to calculate that a child with a body weight of 10-20 kg should be given 250-500 mg twice a day (a quarter or half of the tablet, previously dissolved in water).

A child with a body weight of 20-40 kg is given 500-1000 mg twice a day (half or whole tablet dissolved in water).

Children weighing more than 40 kg are prescribed 1000 mg (that is, one tablet) twice a day.

How much should I take the drug "Vilprafen" (1000 mg)? The duration of treatment with this drug is determined only by the doctor (usually it is 5-21 days, depending on the severity and nature of the infection).

Scheme of anti-Helicobacter therapy (treatment of gastric ulcer)

Now you know how to take "Wilprafen Solutab 1000". If you need anti-Helicobacter therapy, then this medication is prescribed in the amount of 1 g twice daily for 1-2 weeks. In this case, the drug should be combined with other drugs in their standard doses ("Famotidine", "Omeprazole", "Omez", "Omez D", etc.).

The dispersible drug can be ingested by various methods. The tablets are swallowed whole (washed with water) or pre-dissolved in 20 ml of water. In the latter case, it is necessary to mix the resulting suspension well before use.

Side effects after using the drug

Analogues of "Vilprafen 1000", as well as the preparation itself, can cause a number of undesirable reactions. Among the side effects, the following are most often observed:

• Digestive tract: stomach discomfort, abdominal discomfort, nausea, diarrhea, stomatitis, vomiting, constipation, pseudomembranous colitis and decreased appetite.
• Allergies : hives, anaphylactoid reaction, exudative erythema multiforme, Quincke's edema, bullous dermatitis, Stevens-Johnson syndrome).
• Biliary tract and liver: jaundice, hepatic dysfunction.
• Sensory organs: dose-dependent transient hearing impairment.
• Others : purple.

Interaction with other medical devices

Since bacteriostatic antibiotics can reduce the antimicrobial effect of bactericidal antibiotics, their joint use should be avoided.

It is strictly prohibited to administer jozamycin together with lincosamides. This is due to the fact that there may be a mutual reduction in their effectiveness.

Representatives of the macrolide group noticeably slow down the elimination of xanthines. This can lead to symptoms of intoxication.

With the joint use of josamycin and antihistamines containing astemizole or terfenadine, the risk of life-threatening arrhythmias may increase.

There are reports of increased vasoconstriction as a result of the combined use of antibiotics from the macrolide group and ergot alkaloids.

Co-administration of cyclosporine and josamycin causes an increase in the level of cyclosporine in the blood, and increases the risk of nephrotoxicity.

With the combined use of digoxin and josamycin, it is possible to raise the level of the first in the blood.

Special instructions for the use of the drug "Vilprafen 1000"

In the case of severe and persistent diarrhea, it is necessary to keep in mind the likelihood of developing a life-threatening pseudomembranous colitis (against the background of taking josamycin).

In patients with renal insufficiency therapy is recommended to be performed taking into account the results of laboratory tests.

It is necessary to take into account the probability of cross-resistance to various antibiotic agents belonging to the group of macrolides (bacteria resistant to antibiotic treatment, related to the chemical structure, can be resistant to dzhozamycin).

Cost and analogues of a medicinal product

The price of the drug in question is not very high. So, for 10 tablets of the drug you have to give about 150 Russian rubles. Agree, this is a fairly low cost, given the effectiveness of the drug "Vilprafen 1000". Analogues are cheaper you hardly find in pharmacies.

If you are contraindicated with the medication in question, you can replace it with one of the following medications: "Midekamycin", "Roxithromycin", "Spiramycin", "Clarithromycin", "Azithromycin" or "Erythromycin". These drugs are similar to the active substance. There are no so-called structural analogues for this medicine.

Reviews of patients and specialists about a medical device

Today, there are quite a lot of positive reviews about this drug. Patients who have ever taken this medication note its rapid therapeutic effect, which is noticeable after the administration of the first dosages. Especially it is observed at such deviations, as a tonsillitis, an otitis, a genyantritis and a cystitis.

Adverse events after taking the drug are rare. The authors of some reviews speak of a disorder of the stool, as well as of periodic nausea. By the way, these unpleasant effects spontaneously disappear after a few days.

It should also be noted that a large number of patients are pleased with the price of this drug.

In the responses of specialists, the possibility of treatment with the drug "Vilprafen" during pregnancy is noted.