"Theopec" (300 mg): instructions for use, indications, manufacturer

People with asthma know how important it is to help in time for bronchospasm. Sometimes the right actions in this difficult situation can save lives. A significant role in relieving a person of lung problems is played by bronchodilators.

Description of the preparation

"Theopack" (300 mg), the instruction for use of which is given in this article, is a white tablet of flat-cylindrical round shape, which are packaged in a contoured package. The main active substance of the drug is theophylline. Its concentration in one tablet of this form of the drug is 300 mg.

How does the medicine work?

By its pharmacological action, theophylline, which is a purine derivative, has an inhibitory effect on phosphodiesterase. The active component of the drug blocks special purine receptors, stimulates the accumulation of cAMP in tissue stores, reduces the ability of smooth muscle tissue to contract, reduces the amount of free calcium ions that migrate through cell membranes.

A pronounced vasodilating effect of the drug "Theopec" (300 mg) was noted. The instructions for use describe this property as an effect on peripheral blood vessels. Theophylline increases the passage of blood through the kidney system, helps relax the smooth muscles of the bronchi and vessels. Also, the effect of this active ingredient is characterized as a moderate diuretic. Theophylline prevents the release and release of substances that provoke an allergic response, and also increases the stability of the membranes of mast cells. If the patient has hypokalemia, the active substance intensifies the ventilation of the lungs.

Theophylline promotes the normalization of the functioning of the respiratory system, activating the corresponding center in the brain, as a result of which the blood is better saturated with oxygen, the concentration of carbon dioxide decreases. The drug "Teopek" has a stimulating effect on the diaphragm, causing its reduction. It also increases the value of mucociliary clearance, intensifies the activity of respiratory and intercostal muscles.

Theophylline normalizes blood microcirculation, reduces the formation of thrombi, suppresses a specific factor and eliminates the aggregation of platelets. Also, the drug improves rheological blood quality, increases the resistance of red blood cells to deforming factors.

"Theopec" (300 mg) helps to reduce the overall pressure in a small circle of blood circulation, and also reduces the resistance of blood vessels in the lung system. As a result, the tone of the integument of the skin, kidneys and brain is reduced. As a result of the use of theophylline, stimulation of coronary blood flow is observed, increased cardiac activity, increased demand for myocardial cells in oxygen, the pulse becomes faster, the force of the contractions of the heart increases.

Pharmacokinetics and pharmacodynamics of the drug

After the patient took a pill with theophylline, this substance is completely absorbed from the digestive tract. The food consumed affects the absorption rate of the drug, but the clearance and the degree of absorption remain unchanged. 40% of the active substance binds to plasma proteins. Theophylline metabolism occurs in the liver via cytochrome P450 isoenzymes.

The excretion of metabolites in the active form is performed with the help of the kidneys, however 10% of the drug is eliminated in its original form. Some factors have a significant effect on the metabolism of theophylline. Smoking, taking certain medications, dietary habits, accompanying pathologies, age can make adjustments in the exchange of this active substance in the human body. The decrease in clearance of theophylline is observed with pulmonary edema, liver pathology, COPD, as well as with heart failure.

Who is receiving this drug?

There are certain conditions in which the application of "Theopec" (300 mg) is indicated. Instruction for use calls the following diseases:

• Obstructive bronchitis in chronic form;
• Night apnea;
• Emphysema of the lungs;
• bronchial asthma;
• Pulmonary hypertension;
• Pulmonary heart.

Also, the drug "Theopek", which is positive about reviews, can be used in combination with other medicines in the therapy of edema of kidney nature. Patients noted the high effectiveness of this drug and its acceptability for the treatment of respiratory system diseases.

Contraindications

However, this drug can not be used by far not everyone, because of the availability of a number of warnings. Contraindications Theopec has the following:

• Stroke of hemorrhagic type;
• epilepsy;
• Bleeding from the digestive system in history;
• Ulcerative formations in the digestive organs;
• Tachycardia of high degrees of severity;
• Arterial hypertension or hypotension;
• Hypersensitivity;
• Gastritis accompanied by high acidity;
• Children under 12 years.

In the presence of at least one of these syndromes or conditions from taking the drug with theophylline should be discarded

Side effects

There is a fairly extensive group of side effects from taking the drug Teopec (300 mg). Instruction for use divides them according to the system manifestation:

• Disorders of the nervous system: headaches and dizziness, sleep disorder, nervous state, increased anxiety and irritability, tremor;
• Dysfunction of the heart and blood vessels: tachycardia, arrhythmia, hypotension, increased attacks of angina, cardialgia;
• Disruption of normal functioning of the digestive tract: nausea, gastralgia, vomiting, heartburn, reflux, exacerbation of the ulcer, diarrhea, decreased appetite;
• Manifestations of allergic reactions: rash on the skin, febrile conditions, itching;
• Among the other side effects of taking the drug were: tachypnea, albuminuria, increased diuresis, sternal pain, hematuria, flushing to the face, increased sweating, hypoglycemia.

Usually, when correcting the dose of the drug in the direction of decrease, the manifestation of side effects decreases or ceases altogether.

How to take the drug?

Means from bronchitis, such as "Teopek", are prescribed only by the attending physician and their dosage is selected on an individual basis. On average, the daily number of theophylline is 400 mg. If the patient tolerates the drug well, then 2-3 days after taking the first dose of the drug, the volume is increased by 25% and further at the discretion of the doctor.

When taking funds from the bronchitis "Teopek" in a daily dose of less than 900 mg, monitoring the theophylline content in the patient's blood is not necessary. If there is a manifestation of intoxication, then it is urgently required to establish control over the level of concentration of the main active substance in the blood. The optimal values are 10-20 μg per ml. If the content of theophylline in the patient's blood is higher than normal, then the development of negative reactions of the body is observed. In this case, it is required to reduce the dosage of the drug, and the therapeutic effect will weaken.

Can an overdose occur?

Bronchodilators, such as Teopec, can cause serious impairment of body functions in case of an overdose. At improperly selected daily intake of this drug, the following manifestations may occur:

• Decreased appetite;
• Insomnia;
• diarrhea;
• Arrhythmias of the ventricular form;
• tachycardia;
• Bleeding of the digestive system;
• Tachypnea;
• tremor;
• anxiety;
• Hyperemia of the skin ;
• Increased excitability;
• Fear of light;
• Vomiting with blood.

Also, severe poisoning can develop, the symptoms of which are manifested in the following:

• The appearance of epileptic seizures;
• Hypokalemia;
• Renal failure, myoglobinuria;
• Hypotension;
• Confused consciousness;
• Hyperglycemia;
• Metabolic acidosis.

What to do in this case?

If these signs are present or suspected, it is necessary to rinse the stomach, give the patient enterosorbents, laxatives, and also arrange diuresis, plasmosorption, hemodialysis and hemosorption. If the patient has convulsions, then it is recommended to perform oxygen therapy and enter intravenously "Diazepam", which will help effectively stop the seizure. In the case of pronounced nausea and vomiting, intravenous administration of Ondansetron and Metaclopromide should be prescribed.

What drugs can not be combined with TeoPec?

Bronchodilators like "Theopek" are not recommended for taking together with macrolide antibiotics, "Allopurinol", "Cimetidine", "Linkomycin", "Isoprenaline", as well as with oral contraceptives, as all these medicinal substances help to reduce the clearance of theophylline.

It is not recommended to combine the use of beta-blockers, especially nonselective drugs, with the drug Teopek, which can lead to a narrowing of the bronchi and a decrease in the bronchodilating effect of theophylline.

If TeoPek is used in conjunction with Furosemide, caffeine and other substances that stimulate beta-2-adrenergic receptors, the activity of its main component is significantly increased. If you combine theophylline with "Aminoglutite", then the first substance begins to be actively excreted from the body and its effectiveness falls.

"Acyclovir" is able to increase the concentration of the main active substance of "Teopek" and intensify the negative consequences of its administration. Similar phenomena are observed when the theophylline is administered together with the preparations "Dialtheazem", "Felodipine", "Verapamil", "Nefedipin". These drugs do not change the bronchodilator effect, however, the patient may experience symptoms of adverse reactions or overdoses.

The substance "Disulfiram" is able to increase the content of theophylline in the blood to critical levels, dangerous toxic damage. "Propranolol", on the contrary, reduces the clearance of the active substance "Teopek". The concentration of theophylline is increased when it is co-administered with "Enoxacin" and fluoroquinolones. When therapy with theophylline decreases the effectiveness of lithium salts.

In complex treatment with "Phenobarbital", "Carbamazepine", "Isoniazid", "Rifampicin", "Sulfinpyrazonom" the clearance of "Theopek" increases and its effectiveness decreases. With the simultaneous administration of theophylline with "phenytoin", the content of active components in the patient's blood is mutually suppressed.

These guidelines are especially important, ignoring them is fraught with health problems. Therefore, before taking "Theopack", carefully read the instructions. And if you are being treated with any of the above drugs, consult a doctor.

How to buy this medicine and how much is the drug?

In view of the presence of serious contraindications and side effects of this drug, "Theopack" is dispensed in pharmacies only on the prescription of a doctor.

The drug "Teopek", the price of which on average in Russia is 160 rubles, is represented in pharmacies by various manufacturers. One of the varieties is a cure for the Ukrainian pharmaceutical company Borshchagovsky HFZ ZAO NPC. Its cost is 155 rubles. Russian production of the drug "Theopek", 300 mg is carried out at the enterprises of CJSC "Binnopharm" and "Valenta". The cost of these drugs is 290 rubles and 190 rubles, respectively.

In general, the drug "Theopek", the price of which is acceptable, is considered an affordable medicine for many citizens of our country. In comparison with European analogues, this tool is much cheaper. The Russian production of the drug "Theopek" made it affordable.

Special instructions when taking medication

When taking the drug "Teopek", the reviews about which are positive, you should pay attention to the following information. If the patient has coronary or heart failure, atherosclerosis, cardiomyopathy, gastrointestinal ulcer, liver pathology, prostate tumor, reflux, pregnancy, hypothyroidism or a tendency to convulsions, then the drug with theophylline should be taken with caution.

Children under 12 years and elderly patients "Theopack" is appointed very rarely.

It is possible to use rectal forms of the drug, but they should be used with caution in case of rectal and diarrheal syndrome. Patients with a predilection for smoking noted a decrease in the effect of treatment "Theopecom".

It is inadmissible to have a joint treatment with theophylline and xanthine derivatives. If the elderly patient has a significant concomitant pathology, a viral infection, liver, heart and vessel pathologies, then the doctor needs to adjust the dose of the medicine.

Can I take the drug pregnant?

To a pregnant woman this drug is prescribed in the presence of strict indications, since theophylline is able to penetrate the placenta. If the reception of "Teopek" is shown to the nursing mother, then lactation should be stopped.

This manual is a simplified version of the complete instruction, which is attached to the drug "Teopek". You should carefully read it before use. If something confuses you or if you have any doubts, consult a doctor.