The medicine "Reopirin". Instructions for use

The medicine "Reeopirin" is a complex remedy. The medicine is produced in the form of a dragee and an injection solution. The preparation contains aminfenazone and sodium phenylbutazone. The drug has a pronounced analgesic and anti-inflammatory effect. At oral intake a high rate of absorption is observed. With plasma proteins, the active components bind to 98%. The average half-life is about 77 hours. About 27% of the drug is excreted with feces, about 61% with urine.

Appointment

Indications include non-infectious arthritis of a different origin. Among the pathologies in which the "Reopyrin" remedy is recommended, the instruction indicates lumbago, retinitis, iridocyclitis, iritis, parametritis. Assign a medicine for polyserositis (on the basis of severe pain syndrome), pericarditis, adnexitis, polyneuritis. The remedy is used to eliminate manifestations of pathologies of extraarticular soft tissues and the spine, neuralgia, neuritis.

The medicine "Reopirin". Instructions for use

For rheumatic pathologies, the medication is recommended by mouth every day for four to six dragees. Therapy is continued until the symptoms are completely eliminated. The agent "Reopirin" (injections) for these diseases is administered at a dose of 5 ml every day or with a break per day. The injection is carried out deep into the buttock for one to two minutes using a long needle. With adnexitis or parametritis, the drug is recommended intramuscularly. Dosage is also 5 milliliters. The duration of the course is four or five days. For children from 7 to 14 years, the preparation "Reopirin" (instructions for use contains such information) is prescribed orally or half-a-day or whole tablets per day, or 0.5-1 ml per day or every day is injected into the muscle.

Side effects of the drug

The drug "Reopirin", reviews of patients about which after the therapy in most cases are positive, with the observance of medical prescriptions is well tolerated. However, side effects were noted in some patients. Medication can cause negative consequences on the part of the hematopoietic system. In particular, there is thrombocytopenia, leukopenia or anemia. With prolonged therapy in high dosages, agranulocytosis develops. These manifestations are relatively rare. On the basis of treatment, tachycardia, frequent stools, lesions in the digestive system of an erosive ulcerative nature are likely. Some patients experience epigastric pain, vomiting, drowsiness, hives, nausea. To undesirable consequences include the increased frequency of stool, sodium and water retention, skin rash. In the treatment with "Reopyrin" (instructions for use warn about this), hematuria, glucosuria, tubular renal necrosis (with prolonged use in an increased dose) is likely. Of the local reactions, there is an abscess in the site of introduction or painful sensations.

Contraindications

The drug "Reopirin" instruction for use does not allow for vices, heart rhythm disorders, chronic cardiomyopathy. Do not recommend a medicine for edematous syndrome (history, including), hypersensitivity to components, pathologies of the hematopoiesis system.

Appointment of medication for pregnant and lactating women

In prenatal period, therapy is allowed in the presence of strict indications. In connection with the increase in chromocyte aberrations (mutations) in lymphocytes under the influence of the "Reopirin" remedy, the instruction for use recommends strict medical control over the patient's condition. Safety of application during lactation is not established. If necessary, the treatment should be stopped during this period.

Additional Information

Prescription of the medicine to children is carried out in exceptional cases. Therapy is carried out under steady conditions under the supervision of a doctor. In the process of treatment, it is necessary to ensure strict control of urine, peripheral blood, liver activity. Parenteral administration is not recommended for predisposition to epilepsy. On the basis of prolonged treatment, a weekly monitoring of the number of leukocytes should be carried out.

Overdose

The state of intoxication is manifested by vomiting (most often with blood impurities), convulsions (in children), psychosis, hallucinations. The use of increased doses of medication provokes liver failure, jaundice, disorders of the hematopoietic system, changes in the ECG. These phenomena become pronounced in two to seven days. Poisoning is also accompanied by high temperature, disturbances in electrolyte metabolism. Due to the lack of a specific antidote, standard measures are recommended.

Are there analogues of "Reopirin"?

To begin with, it should be said that, despite the high efficiency, the drug is withdrawn from sale in Russia. The exact analogues of "Reopirin" are also not produced. The only, perhaps, drug that has this kind of action is the drug Butadion. This agent contains phenylbutazone, which is present in the drug "Reopirin".