The drug "Dopegit": reviews of doctors

Helps to stabilize the increased pressure of the drug "Dopegit". The comments of medical specialists say that it acts quickly and effectively. It is inexpensive. It is sold in almost every pharmacy. It is allowed to be taken by pregnant women. The medicine has contraindications, therefore it is not necessary to drink it without the appointment of a doctor.

Composition and form of release

The drug "Dopegit" (reviews of experts confirm that this is the only cure for pressure that is prescribed for pregnant women with hypertension) is available in tablets. The pills have a white, slightly grayish color. Contain about 282 mg of active ingredient - methyldopa sesquihydrate. This amount is identical to 250 mg of methyldopa. Additional components of tablets are:

• corn starch;
• Stearic acid;
• talc;
• Sodium carboxymethyl starch;
• Ethylcellulose;
• Magnesium stearate.

Tablets are packed in dark glass bottles of fifty pieces. They are accompanied by instructions for use.

Pharmacological action of the drug

The tablets "Dopegit" refer to the centrally acting anti-hypertensive agents of the central effect (reviews of medical workers indicate that many women drink this medicine throughout pregnancy). Getting into the body, the medicine is transformed with the creation of alpha-methylnoradrenaline, which has an antihypertensive effect by affecting certain mechanisms. The drug lowers sympathetic tone. This is due to the activation of the main inhibitory presynaptic α2 receptors.

The drug acts as a false neurotransmitter and replaces endogenous dopamine on the nervous dopaminergic endings. Reduces the activity of renin in the blood and similarly affects the overall peripheral resistance. It stops the synthesis of norepinephrine. Reduces the formation of adrenaline, dopamine, norepinephrine and serotonin due to suppression of the activity of the enzyme dopa decarboxylase.

The active substance - methyldopa - does not affect the work of the heart organ and does not reduce cardiac output. Does not provoke the appearance of reflex tachycardia. Does not affect the speed of glomerular filtration. Does not affect the renal blood flow and does not exert any pressure on the filterable fraction.

Sometimes, when taking medication, your heart rate may decrease. Medication quickly reduces blood pressure. In rare cases, it can cause postural hypotension.

After the first administration of the tablets, the greatest effect is observed after 4-6 hours and lasts from 12 to 24 hours. The medicine allows to lower pressure on the second-third day of taking the tablets.

Indications

Indication for the use of the drug "Dopegit" (reviews claim that a drug can be bought without problems in any pharmacy) is hypertension. This medication is very often prescribed to pregnant patients.

Contraindications to the use of medicine

They note that the drug "Dopegit" gives a good effect on the pressure, reviews of doctors. Despite this, the drug is not prescribed for hepatitis in the acute stage of development and cirrhosis of the liver. Prohibition of the use of abnormalities liver organ in history. Contraindication to use is the treatment with MAO inhibitors. You can not drink tablets with a depressive state, hemolytic anemia, as well as myocardial infarction in the acute stage of development.

Do not prescribe medication for pheochromocytoma to children under the age of three and with special sensitivity to the constituent substances of the drug.

With extreme caution, patients with renal insufficiency should take pills. This requires a dose adjustment. To be under medical supervision during taking the drug should patients with diencephalic syndrome, elderly people, children from three years old.

Dopegit during pregnancy and lactation

The drug "Dopegit" is actively used in obstetrics for more than fifty years. During this time there were no incidents with teratogenic effects of the drug on the fetus. As a result of clinical trials, a remote risk of exposure to tablets on the embryo was established.

The drug during pregnancy penetrates the placenta, so the patients in the "position" should be under constant medical supervision. "Dopegit" with lactation (reviews note that doctors do not recommend taking pills while breastfeeding the baby) is able to penetrate into breast milk. At the time of treatment, doctors are advised to stop breastfeeding.

When pregnancy begins therapy with a medication from the twentieth gestational week. Children born to women who were treated with Dopegit had no complications. A completely different picture was observed in pregnant women who refused therapy with this drug. Their babies appeared with neurological abnormalities, which appeared due to prolonged oxygen starvation.

The drug "Dopegit" during pregnancy:

• Reduces the resistance of peripheral vessels.
• Reduces the production of renin.
• Adjusts the diastolic pressure back to normal.
• Partially replaces dopamine, a component that increases blood pressure.
• Has a mild soothing effect.

It has not been clinically proven that the medicine can harm a child by penetrating breast milk or the placenta. "Dopegit" instructions during pregnancy (reviews say that this drug does not harm the baby) recommends prescribing when the intended benefit for the mother significantly exceeds the possible risk to the baby.

Dosing and Administration

The drug "Dopegit" is consumed orally. Tablets are not chewed and washed down with water. Pills are taken half an hour before meals or 30 minutes after eating.

The first two days of medication are advised to drink 0.25 g three times a day. Dosage is set based on the blood pressure level. With good tolerability of the drug, the dose is gradually increased every two days. After three days of treatment, "Dopegit" has a mild sedative effect.

The norm for patients with hypertension is 0.5-2 g. It is divided into equal shares and consumed up to four times a day. The maximum daily dosage is 3 g.

If, with a daily dose of 2 g, the treatment did not work and the pressure is poor, then "Dopegit" is prescribed in combination with other antihypertensive drugs or replaced with another drug.

Medication can be given to patients who use other antihypertensive drugs in therapy, but with the condition of their cancellation in the future. In this situation, treatment starts with 0.5 g per day, gradually, if necessary, the amount of the medication is increased with a periodicity of 48 hours.

Elderly people should begin treatment with 0,125-0,25 g. They can not take more than 2 grams per day. In childhood from three years, the drug is prescribed at the rate of 10 mg per kilogram of the child's weight. The resulting dosage is divided into several doses.

Do not take more than 65 mg of medicinal product per kilogram of weight, and the daily dosage should not exceed 3 g. After three months of using "Dopegita", tolerance to the drug often appears. In this case, additionally prescribe diuretics and antihypertensive drugs.

Dopegit: instructions for use in pregnancy

Experts say that the tablets are easily transferred and almost do not cause side effects. Because of this, they are often prescribed in the gestational period. The medicine has few contraindications and does not have toxic effects on the fetus. This property makes it possible to take it pregnant for an extended period, up to the time of delivery. In pregnancy, treatment with pills should be accompanied by a doctor's supervision and by monitoring blood tests.

It is said that the "Dopegit" pressure is quickly restored to normal during pregnancy, reviews. Dosage is determined by the doctor individually. First, a woman is examined. Then, according to the results of the tests, the dose is adjusted. Usually begin treatment with one tablet 250 mg per day. They watch how the drug is transferred. With good tolerance, the dosage is increased gradually, with an interval of two days. Take the drug until the pressure comes back to normal. The maximum daily dose for pregnant women is 2 g.

"Dopegit" to ladies in the position is appointed only in cases of extreme necessity. Usually in the second and third trimesters. The drug is needed by pregnant women to prevent late gestosis, and that the fetus develops normally.

The medicine helps to reduce the pressure by 10-20%, which makes it possible for a pregnant woman to feel normal.

Side effects

Tablets "Dopegit" reviews pregnant women are considered the best drug for stabilizing blood pressure. Despite this, the drug can cause such negative phenomena as drowsiness, lethargy, inhibition. When taking medication, sometimes there is paralysis of the facial nerve, dizziness, gait unsteadiness, parkinsonism. From taking the medication there were headaches, orthostatic hypertension, myocarditis, bradycardia, increased heart failure and angina. There were peripheral edema, hyperemia, pericarditis.

With therapy "Dopegit" appeared glossalgia, dryness of the oral mucosa, diarrhea, vomiting reflex, colitis. The patient may be concerned with hepatotoxicity, jaundice and pancreatitis when taking the pills. There was fixed leukopenia, agranulocytosis, hemolytic anemia and thrombocytopenia.

The drug can cause myalgia, gynecomastia and arthralgia. Provoke galactorrhea, amenorrhea and hyperprolactinemia. To reduce libido and potency.

In isolated cases, fever arose in the treatment, Lyell's syndrome. Worried patients were rashes on the skin, exanthema. There was a nasal congestion and inflammatory processes in the salivary glands.

Shelf life, storage method

The drug is produced in Hungary by EGIS. The medicine should be stored at a temperature of +15 to + 25 ° C. In a place protected from children and the sun. Shelf life of the tablets is five years. Medication can not be used after this period.

Cost of medicine

It is strongly recommended that you consult with your doctor before using Dopegit for instructions on how to use it. Doctors say that this medicine is the safest of all reducing the pressure, so it is prescribed to pregnant women.

You can buy medicines in almost every pharmacy. The price of 50 tablets of 250 mg fluctuates around 200-250 rubles.

Reviews of doctors

Doctors often prescribe Dopegit tablets during pregnancy. The doctors' comments indicate that the medicine does not affect the work of the heart. Do not provoke the appearance of tachycardia and does not reduce cardiac output. In their opinion, the drug reduces blood pressure by reducing the volume of blood circulation, as well as the intensity of heartbeats.

Doctors allow the use of the drug during pregnancy, but remind that it should be drunk only on strict indications. Take it to safe medicines. They say that pills can not harm a future child and do not affect his development. The drug retains its effect during the day, which is its additional advantage.

Doctors consider this medicine to be weak and practically to anyone, except for pregnant women, it is not prescribed.

Dopegit during pregnancy: reviews

Perhaps, one of the most common drugs that are prescribed during pregnancy is "Dopegit". Pregnant women, who are worried about hypertension, drink it until the very birth. It is said that it quickly and effectively reduces pressure. Everyone who took these pills was happy with the result and gave birth to healthy babies. They note that the medicine does not affect the development of the fetus, but, on the contrary, helps to prevent late gestosis, contributes to the normal intrauterine development of the baby.

"Dopegit" during pregnancy reviews caused and negative. These people note the low effectiveness of the drug. They say that it lowers blood pressure and practically does not help. May cause weakness and drowsiness. Some do not like the price and the fact that the drug should be drunk for a long time.