The drug "De-Nol": the composition of the drug, instructions, indications, analogues and reviews

Given the fact that modern food culture does not contribute to the normal functioning of the digestive tract, more people are faced with problems such as ulcers or gastritis. One of the most effective drugs for treating these diseases is De-Nol. The composition of the remedy is designed in such a way as not only to eliminate the symptoms, but also to influence the cause of their appearance.

About the preparation

The composition of the tablets "De-Nol" is based on bismuth subcitrate, which acts as an active substance. It is an astringent drug that has a wide range of properties. Especially noted antimicrobial and gastrotsitoprotektornoe action. This is due to the complex effect on all links of peptic ulcer and gastritis. Getting into the body, bismuth subcitrate precipitates proteins due to the formation of chelate bonds. Thanks to this, a protective shell forms on the walls of the digestive organs.

Specialists note the directional effect of the drug "De-Nol". Reception promotes the formation of a protective film exclusively on those parts of the internal organs, where there are erosive changes. This helps to eliminate the effects of acids and other substances, and therefore tissue scarring occurs much faster. Thus, the acidic environment of the stomach does not irritate the damaged areas, but on the contrary acts as a catalyst for the effect of the drug.

It will help you to get exhaustive information about the "De-Nol" preparation instruction. The composition contains components attributed to the ability to suppress Helicobacter pylori. Penetrating into the cellular structure of this microorganism, the drug blocks its fermentation, which eventually leads to the death of the bacterium. In addition, there is a decrease in the mobility of other microbes. Bismuth subcitrate is highly soluble, and therefore it penetrates deep enough into the mucous membrane, where pathogenic organisms can be contained. Thus, not only treatment, but also prevention of recurrence of peptic ulcer occurs. To date, specialists have not identified varieties of bacteria that have resistance to the active substance of the drug.

Form of issue

In the form of tablets, De-Nol is produced. The composition determines the white color with a barely noticeable cream shade. Tablets are rounded, and also have a convexity from two sides. An original protection from counterfeits is an extruded pattern in the form of a square with rounded corners and interrupted sides. Tablets do not have any flavor, but in some cases a faint smell of ammonia is possible.

The drug "De-Nol": composition

The drug manufacturer claims that it contains substances that can overcome not only the symptoms of ulcers and gastritis, but also the cause - Helicobacter pylori. This is the reason for such popularity of the "De-Nol" means. Its composition is as follows:

• Bismuth tricalcium dicitrate ;
• Bismuth oxide;
• corn starch;
• Povidone;
• Sodium polyacrylate;
• Macrogol;
• Magnesium stearate;
• Hypromellose;
• Macrogol.

Mechanism of action

High efficiency is characterized by "De-Nol". The reception of this agent is associated with the appearance of a gastro-cytoprotective effect, which is caused by such mechanisms:

• Stimulation of prostaglandin production, which stimulates the formation of substances forming a protective barrier on the mucosa;
• Improvement of blood microcirculation in the area of the duodenum and stomach, which contributes to the acceleration of cell regeneration;
• Decrease in the intensity of production of hydrochloric acid by the corresponding glands of the stomach;
• The drug is characterized by a cumulative effect due to a gradual increase in the amount of active substance in the blood;
• The remedy is completely excreted from the body with feces.

Indications for use

One of the most popular drugs for the treatment of gastritis and other gastrointestinal diseases is De-Nol. Indications for the purpose of this drug are as follows:

• Ulcer of the stomach or duodenum in acute form;
• Gastritis and gastroduodenitis in acute or chronic form;
• Irritable bowel syndrome, which is accompanied by a disorder of the stool (diarrhea);
• Damage to the mucous membrane and the walls of the stomach after using anti-inflammatory non-steroid agents;
• Functional dyspepsia, which is not associated with gastrointestinal problems.

Basic Contraindications

Before you drink "De-Nol" with gastritis, you should make sure that you have no contraindications to this drug. The instruction indicates such restrictions:

• Kidney failure;
• Pregnancy and lactation;
• Age up to 4 years;
• Individual intolerance or hypersensitivity to the components of the drug.

Application of the drug

Tablets "De-Nol" have proved to be good. The instruction contains exhaustive information on the method of application and dosage. So, adults should take 1 tablet four times a day. The first 3 receptions are held half an hour before meals, and the last - before bedtime. Also, a scheme is acceptable when twice a day take 2 tablets half an hour before meals.

Children under 12 years of age are prescribed daily intake of 2 tablets of the drug. As in the previous case, food intake is possible in half an hour after taking the medicine.

A different scheme works for kids up to 8 years old. The daily norm is defined as 8 mg per kilogram of the baby's body. The number of receptions is equal to the number of tablets (or parts thereof) that meet the norm.

The composition of the drug "De-Nol" causes the fact that the treatment should last 4-8 weeks. In the next 2 months, treatment with any other drugs containing bismuth is prohibited. To combat the pathogens provoking erosive changes, it was more effective, it is permissible to combine "De-Nol" with antibacterial agents.

Exceeded recommended dosage

Only in case of strict observance of all recommendations is possible a positive effect of taking the "De-Nol" facility. The composition of the drug is such that an overdose can cause a number of unpleasant symptoms. In the instruction there was a violation of the kidneys, which can be disposed of after the drug is discontinued.

In order to alleviate the symptoms of overdose, first of all resort to washing the stomach. Then symptomatic therapy is carried out. So, in most cases, chelating agents are prescribed, which contribute to the restoration of kidney function. If there is a serious violation in their work, they resort to the procedure of hemodialysis.

Interaction with other drugs

It is necessary to observe some caution, combining with other drugs the drug "De-Nol". The composition of the drug is such that it is able to block the absorption of tetracycline. Any other medicines, liquids and food (especially antacids, fruits, dairy products) significantly reduce the effectiveness of the "De-Nol". Thus, there should be a half-hour interval between their use.

The drug "De-Nol": side effects

Before using the drug, you should carefully read the instructions. So, the composition of tablets "De-Nol" causes the following side reactions:

• nausea and vomiting;
• Frequent stools;
• Constipation;
• Itching;
• Rash on the skin;
• Encephalopathy.

These symptoms are temporary and are caused by the accumulation of the active substance in the body. In most cases, unpleasant manifestations disappear immediately, as soon as the patient stops treatment with the drug.

additional information

The main characteristic that determines the effectiveness of a drug such as "De-Nol" is composition. The instruction for use contains such additional information:

• Do not take the drug for longer than 8 weeks;
• Do not exceed the daily dose (this applies not only to children, but also adults);
• The drug can not be taken at the same time as other drugs that contain bismuth;
• During treatment, it is possible to stain black stool;
• Sometimes there is a slight darkening of the tongue;
• At the moment there is no data on the influence of "De-Nol" on the ability to drive vehicles;
• During treatment, "De Nol" is not recommended to drink alcohol;
• Released in a pharmacy without a prescription.

Complex treatment

Often, the treatment of ulcers and gastritis requires an integrated approach. "De-Nol", "Amoxicillin" and other means take together to provide a comprehensive impact on the problem. So, the scheme of complex treatment can be the following:

• Twice a day for half an hour before a meal they drink "De-Nol";
• Twice a day you need to drink 500 mg of "Clarithromycin";
• According to the same schedule, but already 1000 mg take "Amoxicillin".

Sometimes a different scheme is used to treat ulcers and gastritis:

• Twice a day for half an hour before a meal they drink "De-Nol";
• Four times a day take 500 mg of "tetracycline";
• In a similar dosage, but three times a day, they drink Metronidazole;
• "Omeprazole", "Lansoprazole" or other inhibitors of the proton pump are taken according to the instructions.

If you decide to undergo a comprehensive treatment using the drug "De-Nol", taking medication should continue for 1-2 weeks. Complex therapy can not be abruptly terminated. After the completion of the course, the reception of "De-Nol" can be continued up to 8 weeks. This will speed up the regeneration of the mucosa.

Popular analogues of "De-Nol"

The main drawback of advertised medicines is the high price. The most important characteristic of the "De-Nol" is the composition of the drug. Analogues with similar components can cost an order of magnitude less. At the same time, their effectiveness remains as high. So, the most popular substitutes for "De-Nol" are such means:

• "Misoprostol" is a synthetic analogue of prostaglandins, which are hormone-like substances. The effect of this remedy is aimed at protecting the stomach from erosive changes by reducing the amount of gastric juice produced. In turn, the production of mucus and bicarbonate is significantly increased. Blood flow also improves.
• "Karbenoksolon" is a drug based on licorice root. Its action is aimed at increasing the secretion of mucus and increasing its viscosity, which has a positive effect on the condition of the walls of the stomach.
• "Novobismol" is a domestic analogue of the considered preparation, which is also manufactured on the basis of bismuth. It is an antiulcer drug that has astringent, enveloping and antimicrobial action. This is one of the few analogues, which, like the "De-Nol", suppresses Helicobacter pylori. Despite the fact that the tool has a similar composition to the original, it is only available on prescription. This is due to the insufficient amount of excipients that soften the action of the main component.
• "Ulkavis" is similar to "De-Nol" in terms of concentration of the main active substance. This agent also provides enveloping, regenerating and antibacterial effects. The medicine is dispensed without a prescription, but it is advisable to perform therapy under the supervision of a doctor, as exceeding the drug concentration in the blood can lead to the development of encephalopathy. As a rule, this drug is 2 times cheaper than the "De-Nol", but not inferior to it in terms of quality.
• "Ventrisol" refers to gastroprotective drugs. Like the "De-Nol", the medicine works selectively, affecting only damaged tissue. In those places where there is no epithelial tissue, the active component reacts with proteins, forming a protective layer to prevent further destruction, and also for the purpose of subsequent regeneration.
• Vis-Nol is a preparation based on colloidal bismuth subcitrate. The action of the drug is based on the formation of a protective film, which will contribute to the process of scarring of ulcers.
• "Vikalin" - a domestic preparation in which structure natural components prevail. In addition to the astringent and antiseptic effect, it also has an antispasmodic and laxative effect. There is also a decrease in the acidity index.
• "Ventrisol" is a Polish preparation based on bismuth tricalium dicitrate. Reduces acidity and fights Helicobacter pylori. Stimulates the active production of mucus, which serves to form a protective shell.

Positive reviews

Certainly, before using any drug should consult with specialists. Nevertheless, doctors often prescribe a prescription, based only on advertising data, and not on experience of use. Thus, before starting reception it is advisable to get acquainted with the opinion of users. So, the following positive responses can be heard about the drug:

• In the process of treatment, the drug acts not only on erosive changes, but also kills the pathogenic microflora in the intestine;
• After adaptation to the drug, side effects go without undoing;
• Despite the fact that the drug kills gastric bacteria, it does not belong to antibiotics, and therefore its administration is not accompanied by problems characteristic of this group of drugs;
• After completing the full course, the Helicobacter pylori problem is solved, which is confirmed by appropriate analyzes before and after taking the medication;
• To protect yourself from buying a fake, you can call the manufacturer's hotline, which will confirm or deny the authenticity of the lot number indicated on the package;
• Reduces the level of acidity, which not only contributes to the recovery process, but also eliminates heartburn;
• Improves the digestive system as a whole;
• In the majority of patients there is a good tolerance of the drug;
• In the instructions of the drug the scheme of complex treatment is given.

Negative feedback

Treatment with the same drug may have a different effect on patients. So, there is a number of negative reviews about the drug "De-Nol". The most significant are the following:

• The result does not come immediately, and significant relief is noted only after 2 months from the time of the beginning of the admission;
• In case of serious problems with the digestive tract itself "De-Nol" can be ineffective and requires the use of an additional set of medicines;
• In the first 5-10 days of treatment, the side effects described in the instructions may be observed;
• Some patients notice a metallic taste in the mouth;
• high price;
• A long course of treatment;
• The tablet is difficult to break in half and into smaller parts, which is required in the treatment of young children, but because the drug simply crumbles and spoils;
• Given the high cost and popularity of the drug, there are a lot of fakes on the market;
• In some cases, two or more treatment courses may be needed for complete recovery;
• There is no immunity from repeated infection of Helicobacter pylori;
• During the treatment of "De-Nol" you can not use dairy products.

Conclusion

For a long time, such diseases as gastritis and ulcers, with difficulty yielded to treatment. A significant step forward was the discovery of the bacterium Helicobacter pylori, which is the cause of such problems. So, recently, one of the most popular and effective drugs is "De-Nol". This agent is characterized not only antimicrobial, but also astringent and regenerating function. Thus, the "offensive" on the gastrointestinal diseases occurs immediately through several "fronts," which allows to solve the problem completely.

Nevertheless, the intake of De Nol alone is not enough to completely cure gastritis and ulcer. A complex treatment with a number of other drugs (including antibiotics) is recommended. In addition, therapy is often prolonged, which largely depends on the degree of development of the disease. And given the high cost of the drug, a full course may require significant material costs. Nevertheless, as practice shows, none of the analogues known at the moment can boast of the same high efficiency as "De-Nol".