"Mirapex": instructions for use, description, reviews

In this article you will learn everything about the preparation "Mirapex": how to replace this drug, its effect, contraindications to use, side effects, special instructions when it is used. These tablets can cause abnormal behavior and affect the patient's reactions. Therefore, before receiving the drug "Mirapex" instructions for use should be carefully studied. Also, we will talk about the compatibility of these tablets with other drugs.

Prolonged "Mirapex": general information about the preparation and indications for use

The active substance of the drug "Mirapex" is pramipexole. Auxiliary components of tablets: povidone, mannitol, starch, aerosil, magnesium stearate.

With the help of this medication, idiopathic (not dependent on other lesions) syndrome of restless legs and Parkinson's disease, as well as other specified motor and extrapyramidal disorders, is performed.

Form release: tablets "Mirapex PD" 3 mg, 4.5 mg, 1.5 mg, 0.75 mg, 0.375 mg. They are packed in blisters of 10 pieces, and then in cardboard bundles.

Tablets of white color. They have a beveled edge and a flat form on both sides, one of which has a deep risk.

Tablets should be taken orally regardless of meals. Drug use is acceptable at any time. In doing so, it should be washed down with water. It is recommended to divide the daily dose into three doses.

Mechanism of action (pharmacodynamics) of tablets "Mirapex"

The active substance pramipexole, which contains the preparation "Mirapex", specifically and with high selectivity enhances the response of dopamine receptors from the D2 subgroup. Due to it, the lack of motor activity in case of Parkinson's disease is compensated. This is due to the activation of dopamine receptors in the striatum. In this case, pramipexole prevents the degeneration of their neurons, which arises because of neurotoxicity or ischemia. It suppresses or reduces the rate of synthesis, metabolism and release of dopamine. Thanks to pramipexole, neurons are protected from the toxic effects of the anti-Parkinsonian drug "Levodopa". Also, due to its effect, the production of prolactin (dose-dependent) decreases.

In the case of long-term use of Mirapex tablets for the treatment of Parkinson's disease (more than three years) and the syndrome of restless legs (more than a year), there was no decrease in the efficacy of pramipexole.

Biochemical processes occurring with the drug "Mirapex" in the patient's body (pharmacokinetics)

The active substance of the preparation "Mirapex" is completely and rapidly absorbed after ingestion. Its ability to assimilate (bioavailability) is almost absolute - more than 90%. The maximum concentration of the drug in the plasma is observed after 1-3 hours after its use. At meals, the rate of absorption of pramipexole is reduced. At the same time, the volume of digestible food does not change.

With proteins, pramipexole binds slightly (less than 20%). It has a large volume of distribution - 400 liters, which means that its concentration in the blood is low. To a small extent, the drug is exposed to the process of metabolism. Approximately 90% of the dose of "Mirapex" tablets is excreted by the kidneys, while 80% is unchanged. In feces, pramipexole is found in an amount of less than 2% of the amount consumed. Tissues and body fluids are cleaned from Mirapex tablets at an average rate of 500 ml / min.

Use of the drug "Mirapex" during pregnancy

Can I use MIAPEX tablets during pregnancy? Instructions for use of the drug explains that the effect of the drug on the development of the fetus in the womb and lactation was not investigated.

The possible effect of pramipexole on the systems and organs responsible for the process of fertilization was studied in the course of experiments on animals. At the same time, there were no manifestations of fetal development disorders during pregnancy in rabbits and rats.

Excretion of pramipexole with breast milk has not been studied. One can only assume that the substance can suppress lactation, as it inhibits the production of the luteotropic hormone. Therefore, it is not recommended to take Mirapex tablets during the breastfeeding period.

During pregnancy, the drug should be taken only when the potential benefit for the expectant mother exceeds the risk to the fetus.

Contraindications to the use of tablets "Mirapex"

The drug "Mirapex" can not be taken in case of hypersensitivity to pramipexole, and also to people under the age of 18.

With extreme caution, it is recommended to take tablets with low blood pressure and kidney failure.

Side effects of the drug "Mirapex" on the nervous system

The drug "Mirapex" is a tablet that can cause the following reactions from the side of the nervous system:

• Confusion;
• Excessive craving for sleep or lack of it;
• Hallucinations;
• Amnesia;
• Asthenia;
• dizziness;
• Extrapyramidal syndrome;
• Hypoesthesia;
• tremor;
• Myoclonus;
• Dystonia;
• Depression;
• rave;
• Suicidal tendencies;
• Hypokinesia;
• Ataxia;
• anxiety;
• Malignant neuroleptic syndrome.

The latter manifests itself in the form of hyperthermia, impaired consciousness and thinking, muscle rigidity, vegetative lability, akathisia.

Side effects of tablets "Mirapex" on other systems of the human body

The musculoskeletal system can respond to the use of the drug "Mirapex" with such manifestations:

• Hypertonic muscles, their cramps, twitchings;
• The occurrence of arthritis, myasthenia gravis or bursitis;
• Pain in the chest, neck or spine (in the lumbosacral section).

Deviations in the digestive system may also occur. In this case, the following occurs:

• Decreased appetite;
• Constipation;
• nausea;
• dyspepsia;
• flatulence;
• diarrhea;
• Vomiting;
• Dry mouth;
• Cutting sensations in the abdomen.

For the respiratory organs, taking Mirapex may result in the development of sinusitis, pharyngitis, rhinitis, and flu-like syndrome. Also, the occurrence of dyspnea, increased coughing and changes in voice are not excluded.

How does the Miraclex tablets affect the cardiovascular system? Instruction for the use of the drug informs about the possible development of tachycardia, arrhythmia, angina pectoris, orthostatic hypotension.

Other side effects

When taking the drug "Mirapex" in the genitourinary system, complications such as increased frequency of feces, infections can occur. In this case, even a decrease in libido and potency is assumed.

In addition, there may be diplopia, cataracts, conjunctivitis, paralysis of accommodation, allergies, as well as hearing impairment, intraocular pressure.

Other adverse reactions of the body:

• Retroperitoneal fibrosis;
• Pleural effusion;
• Pulmonary infiltration;
• Weight loss;
• Peripheral edema.

Method and dosage of tablets "Mirapex"

You need to take the drug inside, daily 3 times. The initial dose of tablets "Mirapex PD" - 0.375 mg per day. Gradually, the amount of the drug should be increased (every 7 days) until the required therapeutic effect. In the second week of treatment, 0.75 mg should be consumed every day, 1.5 mg at the third, 2.25 mg at the fourth, and 3 mg daily for Mirapex, 3.75 mg for the sixth, and 4.5 mg for the seventh.

In chronic renal failure, the dosage is adjusted based on the levels of creatinine clearance. The exact amount of the drug should be prescribed by a doctor.

Consequences of an overdose when taking MIAPEX tablets

If the dosage has been disturbed when using Mirapex, presumably such symptoms may occur: hallucinations, hyperkinesia, vomiting, nausea, lowering of blood pressure and agitation.

For this situation, the antidote is not installed. Cases of overdose with the drug "Mirapex" is not fixed. Symptomatic therapy, gastric lavage and dynamic observation are recommended. If overdose causes signs of excitation of the central nervous system, then drugs-antipsychotics should be used.

Interactions of MIAPEX tablets with other drugs

Pramipexole binds to plasma proteins to a small extent and undergoes biotransformation. Therefore, its interaction with other drugs that affect these processes is unlikely.

Medications that inhibit or inhibit the active production of cationic substances or self-excreted through the renal tubule can react with the Mirapex tablets. The instructions for use explain that in this case a decrease in the rate of cleansing of tissues and biological fluids or from both drugs or from one of them will manifest itself.

If you simultaneously use such medications with Mirapex tablets, you should pay attention to possible hallucinations, dyskinesia, and arousal. If such signs appear, then the dosage of the drug should be reduced.

Compatibility of tablets "Mirapex" with preparations "Amantadine" and "Levodopa"

What happens when combined preparations of "Levodopa" and "Selegilin" with tablets "Mirapex PD" are taken? The instruction states that the pharmacokinetics of the active substance are not affected either by the first or the second. At the same time, the "Mirapex" tablets are not reflected on the body's complete digestion and the natural withdrawal of "Levodopa" drug.

The interaction of pramipexole with the drug Amantadine was not studied. But their compatibility is possible in therapy, since they have similar removal mechanisms.

When the dose of the drug "Mirapex" increases, the amount of "Levodopa" is recommended to be reduced. At the same time, the number of other antiparkinsonian drugs should be maintained consistently at the same level.

Features compatibility of the drug "Mirapex" with other drugs

In connection with the possibility of cumulative effects, it is recommended to use tablets "Mirapex" in combination with sedatives, alcohol and drugs, which increase the concentration of pramipexole in the blood (for example, with the drug "Cimetidine") with extreme caution.

Special instructions for the use of tablets "Mirapex"

The drug described by us is strongly not recommended to be taken simultaneously with antipsychotic agents.

In the treatment of dopamine agonists, known side effects are confusion and hallucinations. In cases of the use of Mirapex tablets in combination with Levodopa, such deviations were observed more often in the late stages of the disease than in the early stages of monotherapy.

The doctor must necessarily inform patients about the possible occurrence of visual hallucinations. This side effect affects the ability to drive vehicles and make responsible decisions.

With a sharp discontinuation of taking tablets in the case of Parkinson's disease, the appearance of a symptom complex, which resembles a neuroleptic malignant syndrome, was revealed.

Abnormal behavior with the use of the drug "Mirapex"

Patients and caregivers need to be aware of the fact that taking dopaminergic drugs, in particular, "Mirapex" tablets (reviews confirm this), often causes abnormal behavior of the patient. Perhaps the emergence of hyperphagia (the tendency to overeating), pathological shopping (obsessive desire to make many purchases), an irresistible attraction to gambling and hypersexuality. In such cases, it is necessary to reduce the dosage of the drug or gradually stop taking it.

Caution when using MIAPEX tablets

The medicine "Mirapex" should be used with caution by patients with the presence of serious diseases of the cardiovascular system. When conducting therapy with dopaminergic drugs, there is a risk of developing orthostatic hypotension. Therefore, control of blood pressure is required, especially at the initial stage of treatment.

In case of impaired vision, it is necessary to check it regularly after the administration of MIAPEX tablets and then at certain intervals.

Patients should consider the fact that the drug can have a sedative effect. There are cases of sudden falling asleep and excessive drowsiness in the course of daily activities. Including it can happen at any time with the management of complex mechanisms or when driving vehicles.

The possibility of melanoma development

As a result of epidemiological studies, it was found that patients with Parkinson's disease are at risk of developing melanoma. Whether it is the cause of this ailment or other factors, for example, the use of the drug "Mirapex", is not established.

Strengthening the syndrome of "restless legs"

How does MIAPEX affect the restless legs syndrome? The patients' testimonies indicate that dopaminergic drugs can enhance it. This manifests itself in the form of an earlier onset of symptoms of the syndrome in the evening, and sometimes in the afternoon. In this case, the symptoms extend to other limbs. In a 26-week clinical controlled trial that was designed to study this effect, there was no significant difference between the pramipexole and placebo groups in enhancing the signs of the syndrome.

Storage conditions and shelf life

Tablets "Mirapex" refer to drugs from List B. They must be stored in a darkened place. The temperature in the room must not exceed 30 ° C.

Shelf life of the drug is 36 months (3 years) from the date of manufacture.

The use of tablets "Mirapex" in childhood and the conditions of their purchase

The drug is contraindicated in childhood. Allowed the taking of tablets to persons who have reached the age of 18. The medicine "Mirapex" is released in pharmacies upon presentation of a prescription.

Analogues of the medicine "Mirapex"

Can not for any reason buy exactly tablets "Mirapex"? Than to replace a medical product, you should prompt the pharmacist or the doctor. And we offer the following analogs.

1. Tablets "Motopram". Indications for use: Parkinson's disease. It is possible to carry out monotherapy or to combine the drug with the drug "Levodopa". Also used for severe idiopathic or moderate form of restless legs syndrome.
2. "Oprimea" tablets. Purpose: antiparkinsonian therapeutic agent-stimulant dopaminergic transfer to the central nervous system.
3. Pramipexole tablets. Therapeutic agent is used in Parkinson's disease. It is generally believed that the mechanism of its action is directly related to the ability of the substance pramipexole to stimulate the dopamine receptors of the striatum.

Tablets "Mirapex" - analogues or the original? No self-treatment!

The list above lists the drugs that are analogous to the Mirapex tablets. They have the same unique, non-proprietary international name (or ATS code) recommended by WHO (World Health Organization).

If you need to undergo treatment with the Mirapex tablets, analogues can also be a great alternative. But before you replace the prescription medication, always consult with a specialist. Do not under any circumstances do self-medication! This can cause irreversible negative consequences for your health.

Attention! This article with the description of the drug "Mirapex" is a supplemented and simplified version of the official instructions for use. The information on the medicine is presented for the purpose of acquaintance. Do not use it as a guide for self-medication.