"Pyrogenal": reviews and analogues

How effective is the drug Pyrogenal? Reviews about this tool are considered at the very end of the article. In addition, your attention will be presented to the properties of this medication, its form of release and methods of application.

Form, description of the drug, composition

The drug in question is sold in the following forms:

• "Pyrogenal" - injections. Experts say that such a product is available in the form of a colorless and transparent intramuscular solution in ampoules of one milliliter. Its main substance is lipopolysachard, which was isolated from the bacteria Salmonella typhi. Also in the composition of this drug liquid is a buffer phosphate-salt solution with a pH of 6.7-7.3.
• "Pyrogenal" - rectal suppositories. Reviews of pharmacists indicate that such suppositories have a yellowish-white color, as well as a cylindrical shape, pointed at one end. The active component of this agent is bacterial-type lipopolysaccharide and such auxiliary elements as lanolin, purified water and cocoa butter.

Pharmacology of a medicinal product

What is the "Pyrogenal" medication? Experts say that this is a nonspecific highly active immunomodulator that can induce a complex of complex physiological and immunological changes in the patient's body, and also activate fibrinolytic, hypothalamic-pituitary and reticuloendothelial systems.

This drug shows desensitizing, anti-inflammatory and adjuvant properties, and also increases the specific and general resistance of the human body and affects the centers of thermoregulation of the hypothalamus.

Features of the drug

What is remarkable about such a tool as "Pyrogenal"? The doctors' comments say that this medicine is capable of activating macrophages, enhancing phagocytosis, stimulating the production of interleukin-1, which causes the proliferation of body cells, interleukin-2, necessary to support the growth of lymphocytes, induction of interferon (endogenous), tumor necrosis factor and active forms of O2. It should also be noted that the increase in activity of phagocytes accelerates the formation of antibodies and promotes the growth of antimicrobial resistance of the human body.

Thus, thanks to the activation of monocytic-macrophagal series and cytokines secreted by them, the working activity of the humoral and cellular immune response is markedly enhanced.

Under the influence of the preparation "Pyrogenal" in the connective tissue, the processes of development of fibroblasts, as well as the formation of collagen fibers, are suppressed, which ultimately leads to the rejuvenation of the cell composition and the slowing down of glial scarring.

It should also be noted that the reception of the drug in question is able to prevent the formation of new and resorption of previously formed dense scars and adhesions in the injury sites, as well as to prevent vascular obliteration and stimulate epithelialization and tissue regeneration.

Properties of the medicinal product

What features are characteristic for such a medicine as "Pyrogenal"? The reviews indicate that this agent not only stimulates the activity of hyaluronidase and the kinin system, but also improves the fibrinolytic properties of blood, and also increases the active activity of lysosomal enzymes and tissue permeability, accelerates the penetration of medicinal elements into the lesion, eliminates the inflammatory process and restores circulation.

It should also be said that the use of "Pyrogenal" contributes to the activation of the pituitary system, increasing the concentration of hormones in the blood, anti-inflammatory and analgesic effect.

Indications for use

What is the purpose of the medication "Pyrogenal"? The application (reviews of this agent are presented below) of the drug in question is indicated for non-specific therapy:

• With traumatic injuries of peripheral and central HC, cerebral arachnoiditis and spinal hernias;
• In surgery for adhesions, after-burn keloids and contractures, injuries, vascular diseases, and also to prevent vasodilatation;
• With infertility and inflammation of the uterine appendages;
• With chronic liver diseases;
• With adhesive diseases of the abdominal cavity;
• With the torpid current form of tuberculosis at the stage of resorption;
• With severe burns of the visual organs, iridocyclitis, uveitis, corneal opacity, herpesvirus infection of the eyes, neuralgia of the auditory and optic nerve, conjunctivitis and viral keratitis;
• With strictures of ureters and urethra, as well as chronic urethritis and prostatitis;
• With venereal diseases, psoriasis and other ailments of chronic skin;
• With resistance of microorganisms to antibiotic and chemotherapy.

It should also be noted that as a pyrogenic drug, the drug is actively used for indications for pyrotherapy, including dermatovenereology, narcology and psychiatry.

Prohibitions to use

In what cases can not use the drug "Pyrogenal"? The reviews indicate the following contraindications to the use of the drug:

• Chronic illnesses in the stage of decompensation and exacerbation, except for those that are indications for the prescription of the medication;
• Blood diseases;
• Febrile illness (acute);
• Lactation period and pregnancy time.

Patients suffering from kidney disease, chronic ailments of the cardiovascular system and diabetes, Pirogenal therapy should be administered only under the supervision of a doctor.

If there are febrile seizures and convulsive readiness, the medication in question is either not used or injected together with anticonvulsant therapy.

The preparation "Pyrogenal": instructions for use

The doctors' comments say that intramuscular injections of this medication should be performed one day after the injection one day.

To prepare a medicinal solution, the contents of the ampoule must be mixed with sodium chloride.

The course of treatment with this drug starts with a dosage of 2.5 mgk, after which it is gradually increased (every day) by 5 mgk. The maximum permissible single dose of "Pyrogenal" is 100 mgk.

The course of treatment with the drug in question is usually limited to 15-30 injections. Repeated injections can be carried out only after two months.

How should I use the drug in the form of candles? According to the instructions, rectal suppositories use one piece per day (50 mg). The greatest dosage of this drug per day is 200 mgk.

Patients using this form of medicine should follow the following treatment regimen: rectal suppositories are administered three times a day at a dosage of 50, 150, 100 or 120 mgk.

Usually one course of therapy consumes about twelve suppositories. Most often such candles are used for the purpose of immunorehabilitation and for immunoprophylactic treatment in the process of recovery of the patient after acute bacterial and viral diseases in a dose of 100 or 50 mgk. As a rule, the course of such therapy is limited to 10 suppositories.

Combining injections and candles "Pyrogenal" is not prohibited.

Negative Effects

What side effects does the "Pyrogenal" medication cause? Reviews of men and women say that when using suppositories, they often increase body temperature to 37.6-37.8 degrees, and also show primary influenza symptoms such as chills, fatigue, fever, nausea, headaches, arthralgia and myalgia .

As for the solution for injections, when it is administered in patients, the same adverse reactions are observed, pains occur in the lower back.

Interaction

"Pyrogenal" can be combined with the drugs used to treat the above indications. In this case, it should be remembered that as part of complex therapy, this agent can enhance the action of chemotherapeutic drugs.

Similar means

Analogues for the drug "Pyrogenal" for the main active substance there. As for similar drugs for pharmacological action, they include the following: "Prodiogisan" and "Transfer-Factor." By the way, the last drug is considered the most effective and qualitative.

Reviews about the drug

What do experts say about the drug Pyrogenal? Reviews of gynecologists and other doctors are very diverse. According to their statements, the provocation with the medicine "Pyrogenal" promotes a more rapid formulation of the correct diagnosis, as well as the timely initiation of adequate treatment.

As for patients, most of them refer to this remedy exclusively from the negative side, paying special attention to the pronounced painfulness of injections.

It should also be noted that many are simply not ready for such side effects as elevated body temperature and malaise, which manifest themselves at the very beginning of therapy. Although the therapeutic effect of this drug in patients' reviews is not criticized.