Doksi-Chem: instructions for use, reviews, analogies

Angioprotectors include an entire group of drugs that play an important role in the combination therapy of various heart and vascular diseases.

Such drugs show spasmolytic activity, improve microcirculation and rheological properties of blood, and cause vasodilation and normalize their permeability. In addition, angioprotectants reduce swelling of tissues and activate metabolism in the walls of blood vessels.

The most prominent representatives of such drugs include the drug "Doxie-Hem." Instructions for use, analogues and feedback about the tool will be provided below.

Form, description, composition and packaging of the preparation

Doksi-Chem drug, the instruction of which is contained in a cardboard package, is available in the form of hard gelatin capsules with an opaque light yellow body and a dark green lid. Their contents are a yellowish powder. It also allows for the presence of conglomerates that are converted into bulk material when lightly pressed with a glass rod.

What components does the Doxie-Hem product contain? The instruction for use states that the active ingredient of this drug is calcium dobesylate monohydrate. It also includes such auxiliary elements as magnesium stearate and corn starch.

In the sale of the drug in question comes in blisters.

Characteristics of the medicinal product

How does Doxie-Hem work? Instructions for use, reviews of experienced doctors say that this is an angioprotector (i.e., veno-and capillaroprotector), which affects the endothelium of the vessels and normalizes the metabolic processes in it.

After taking this medication, the vascular permeability and microcirculation of blood significantly improves. Also, the stability of capillaries increases, the edematous and hemorrhagic syndrome decreases, the blood viscosity and platelet aggregation decrease .

The therapeutic efficacy of the drug in question is associated with an increase in kinin activity in plasma.

Kinetic features of the drug

What kinetic properties are characteristic for the Doxie-Hem medication? Instructions for use asserts that this drug is slowly absorbed from the digestive tract. Approximately 5.5 hours later, the peak of its concentration in the blood is observed. About 20-25% of the active substance binds to plasma proteins.

This medication is withdrawn within 24 hours through the intestines and kidneys.

Indication of the drug

Why should patients be prescribed an angioprotector such as Doxie-Hem? Instruction, reviews indicate that this medication is very effective when:

• Varicose veins or venous insufficiency, which is accompanied by pain syndromes, superficial phlebitis, congestive dermatosis and trophic ulcers;
• Increased capillary permeability (including diabetic nephropathy and retinopathy);
• Microangiopathy, which developed against the background of cardiovascular diseases.

Contraindications to taking capsules

In what cases should not you prescribe a Doxie-Hem medication? Instruction for use informs that this medication is contraindicated when:

• Gastrointestinal bleeding;
• Exacerbation of peptic ulcer;
• Kidney and liver diseases;
• Hemorrhage, which arose against the background of taking anticoagulants;
• Under the age of 13;
• Hypersensitivity to the drug;
• In the first trimester of pregnancy.

Doxys-Hem preparation: instructions for use

Analogues of this tool will be listed at the end of the article.

Take this drug should only be prescribed by the doctor. Capsules are swallowed whole while eating.

According to the instructions, the average dosage of this medication is 500 mg twice a day. It should be taken for three weeks. If necessary, this dose is reduced to 500 mg per day.

With the development of retinopathy this medication is prescribed 500 mg three times a day for 4-5 months (with a gradual transition to 500 mg per day).

Also, this remedy is often prescribed for prophylactic purposes.

If, after taking Doxie-Hem, the patient has fever, chills, swallowing and swelling of the oral mucosa (i.e., symptoms of agranulocytosis), it is necessary to consult a doctor.

Adverse events

What are the undesirable effects that can occur when taking Doxie-Hem? Instruction for use reports the following conditions:

• Nausea, allergic reactions, diarrhea, chills, vomiting;
• Fever, disorders of subcutaneous tissues and skin;
• Itching, arthralgia, rash;
• Disorders of connective and musculoskeletal tissue;
• Disorders of the lymphatic system and blood;
• Agranulocytosis (this reaction is reversible and occurs after discontinuation of therapy).

Special Recommendations

The drug can be used for the prevention.

In severe renal failure, which requires dialysis, the dosage of the drug should be reduced.

This tool is not recommended for pregnant women and children. It is not recommended to take it to ladies breastfeeding. It should also be noted that this drug has no effect on a person's ability to manage complex mechanisms and driving vehicles.

Price and similar drugs

The cost of the angioprotector "Doxie-Hem" is about 300 rubles. In some cases, it is replaced by such means as "Dobesilat calcium", "Doxium", "Doxium 500", "Doxilek".

Reviews

According to experts, calcium dobezilate has a more pronounced effect on the permeability of blood vessels than etamzilate. Therefore, this drug is very often used as a therapeutic and preventive agent of various diseases of the cardiovascular system.

Patients argue that this medication is a highly effective angioprotector, which is regularly taken by people with diabetes. After Doxie-Hem therapy, the patients have retinal edema decreased, and the prognosis for diabetic retinopathy improves .