Preparations "Methodic" and "Methotrexate" - what is the difference?

In this article, we will consider the preparations "Methodic" and "Methotrexate". What is the difference between them? About this further.

"Methodic" is an antitumor drug, which has a pronounced immunosuppressive effect, it is an antagonist of folic acid. It is able to stop cellular mitosis. Its main function is also inhibition of dihydrofolate reductase, which is the key enzyme that recovers from dihydrofolic tetrahydrofolic acid. The cost of the drug is from 700 to 1100 rubles.

The most famous analogue of the preparation "Methodic" is the Austrian "Methotrexate Ebove".

The cost of it Is in the range from 400 to 1200 rubles.

Composition of the "Methodic"

The main active substance of the drug is methotrexate disodium. Additional components: sodium chloride, sodium hydroxide, distilled water.

Effective against multiplying and fast growing cells. Especially this applies to epithelial cells and malignant neoplasms.

With constant use, it accumulates in the tissues. It is excreted by the kidneys and bile. If the kidney function is impaired, excretion from the body slows down. It can also slow down if the liver works poorly.

Composition of Methotrexate Ebeve

The medicament contains the same active substance - methotrexate. It has immunosuppressive, anti-tumor properties.

It has good bioavailability, is excreted from the body with urine and in small amounts with bile. It has the property of accumulating in tissues in the form of metabolites.

So, the "Methodic" and "Methotrexate" - what's the difference? In composition and action, they are almost identical.

In what cases is the "Method" appointed?

The drug "Methodic" in oncology is used quite rarely. It is prescribed for skin diseases and joint diseases, for example when:

• Psoriasis, which is difficult to treat.
• Rheumatoid arthritis.
• Juvenile arthritis.
• Psoriatic arthritis.

Immunosuppressive properties of the drug and anti-inflammatory drugs are activated. This explains the effectiveness of these ailments.

Use of the drug "Methotrexate"

Basically, "Methotrexate" is prescribed for the treatment of cancer diseases:

• Acute lymphocytic leukemia;
• Trophoblastic disease;
• Skin cancer;
• Cervical and vulvar cancer;
• Esophageal cancer;
• Squamous cell carcinoma of the head and neck;
• Cancer of the renal pelvis and ureters;
• Osteogenic and soft cell sarcoma;
• Ewing's sarcoma, lung cancer, breast cancer;
• Germinogenous testicular and ovarian tumor;
• Liver cancer, kidney cancer;
• Retinoblastoma, medulloblastoma;
• Penile cancer;
• Lymphogranulomatosis.

In addition, it should be noted that the drug is also used for severe forms of psoriasis, as well as for severe rheumatoid arthritis (if adequate therapy has proved ineffective).

That's the difference. "Methodic" and "Methotrexate" are used for various diseases. So, "Methodic" - for the treatment of psoriasis and arthritis, and "Methotrexate" - with oncology. But they can treat both.

Forms of release

"Methodic" is a yellow transparent solution. Sold together with syringes, which are designed to be injected under the skin, into the muscle or vein.

"Methotrexate" is in ampoules and tablets.

How are medications used?

The dosage of the drug is selected by the attending physician on an individual basis. Of course, if there are no contraindications. It is applied no more often than once a week.

The patient must pass the test before use. In advance, about a week, do a test shot with a small amount of medicine, if the body responds normally, then the treatment can be carried out.

If there are side effects, the drug is not used. First, a minimum dose of the drug is administered, which is 7.5 mg. Then it is gradually increased with good tolerability and with available indications.

A couple of months after the first application, you can see the effect. The course can last quite a long time, up to several years.

Use in pregnant and lactating women

Here is the difference? "Methodic" and "Methotrexate" can not be taken during pregnancy and lactation.

"Methodic" is toxic to the fetus, can lead to serious disabilities in development and even to its death. In breast milk has a property to accumulate, which can also negatively affect the health of the baby.

If pregnancy occurred while taking the drug, there may be undesirable consequences for the child. Therefore, careful contraception is necessary during therapy.

We compare the preparations "Methodic" and "Methotrexate Ebove". What's the difference, it became clearer. We understand further.

Contraindications "Methodic"

The drug should not be used if there is a hypersensitivity to the components. Also, do not use it when:

• Abuse of alcohol.
• Diseases of the liver and kidneys.
• Violations of hematopoiesis.
• Presence of ulcerative lesions in the organs of the digestive tract and in the oral cavity.
• Vaccination (due to a decrease in the immune response, vaccination should be carried out only six months after discontinuation).
• Acute and chronic infections (including recently transferred diseases).
• Autoimmune diseases.

Careful application should be, if available:

• Herpes.
• Pleural and peritoneal effusions.
• Ascites.
• Gout.
• Obstructive diseases of the digestive system.
• Dehydration of the body (disturbed water balance increases the toxicity of the funds).
• Asthenia.
• High concentration of bilirubin.
• Vomiting and diarrhea.
• Carrying out of chemical and radial therapy in the anamnesis.

"Methodic" try not to appoint elderly people, as they may have disrupted the work of the liver and kidneys. In particular, do not apply "Methodic" and "Methotrexate" in NNC (ulcerative colitis).

In what cases is it forbidden to use Methotrexate medication?

With pronounced violations of the liver and / or kidney function, leukopenia, thrombocytopenia, pregnancy and lactation. Immunodeficiency states are also a contraindication to the use of Methotrexate.

When a medicine treats rheumatoid arthritis or psoriasis, once a month it is necessary to donate blood to biochemistry, also in the laboratory it is necessary to check the kidney and liver function at a frequency of 1-2 times in two months.

If psoriasis is treated, local therapy is continued with the drug.

If an overdose occurs, the patient must enter a calcium folio within the first four hours.

Interaction with other drugs "Methotrexate"

"Methotrexate" is prohibited from use with the following drugs:

- non-steroidal anti-inflammatory drugs;

- antibiotics of the penicillin series;

- sulfonamides;

- valproic acid;

- colstiramine;

- mercaptopurine;

- neomycin;

- paramomycin;

- omeprazole;

- Retinoids;

- tetracycline;

Cyclosporin.

These are the contraindications for the drugs "Methodic" and "Methotrexate." What is the difference? The reviews confirm that they are carried equally hard.

Interaction of "Methodic" with other means

Simultaneous administration of "Methodic" and other drugs leads either to an increase in toxicity, or to a decrease in the therapeutic effect. If you want to combine any funds, then it is better to report this to a specialist.

"Methodic" take with caution with:

• Hepatotoxic drugs.
• Drugs that oppress hemopoiesis.
• Preparations that affect the bone marrow.
• Alcoholic beverages.
• Antibiotics.
• NSAIDs and salicylates.

The forbidden list of medicines is large enough. It should be remembered that interaction with the "Methodic" will cause a very serious toxic poisoning of the organism (death is not excluded). Sometimes this can lead to skin cancer.

Green tea and coffee are also banned, as well as drinks with alkaloids of purine, theophylline and caffeine. The reason for this is poor compatibility with methotrexate. He can significantly delay their excretion.

It should be noted that the therapy shows the intake of vitamin complexes and preparations containing folates, since they reduce toxic properties.

Which preparation to choose - "Methodic" and "Methotrexate"? What's better? About this further.

Side effects

Side effects can be different, but most often the organs of the gastrointestinal tract suffer. With what frequency and severity they arise, depends on the dose and individual characteristics of the organism.

The side effects are mainly:

• Stomatitis.
• Nausea.
• Depression.
• Anemia.
• Dermatitis.
• Headache and dizziness.
• Increased sweating and fever.
• Allergies and anaphylactic shock.
• Pericarditis.
• Thromboembolism.
• Interstitial pneumonia.
• Various infectious diseases.

Sometimes:

• Vomiting.
• Hair loss.
• Vasculitis.
• Pharyngitis.
• Paresthesia of lower extremities, fingers and toes.

Very rare:

• Seizures and paralysis.
• Visual impairment.
• Pulmonary insufficiency.
• Myalgia.
• Osteoporosis.

May develop pancreatitis, diabetes, impotence, infertility, and even the appearance of neoplasms is not ruled out.

What is the difference between the preparations "Methodic" and "Methotrexate"? This question interests many.

It is necessary to undergo regular examinations to those patients who are treated with the "Methodic". This can prevent intoxication. The severe consequences of this are terrible, a fatal outcome is possible.

It is forbidden to drive a car during therapy and work with dangerous equipment.

Next, consider the side effects of drugs such as "Methodic" and "Methotrexate." What is the difference between them?

Side effects of Methotrexate

On the part of the digestive organs are possible manifestations of ulcerative stomatitis, anorexia, gingivitis, pharyngitis, nausea; In rare cases - diarrhea, melena, enteritis, pancreatitis, liver necrosis, cirrhosis, fatty atrophy, periportal liver fibrosis.

The hematopoiesis system can respond with leukopenia, anemia, thrombocytopenia.

The central nervous system is a feeling of fatigue, dizziness; In rare cases - headache, aphasia, drowsiness, convulsions.

Reproductive system - violation of ovogenesis and spermatogenesis, oligospermia, violation of the menstrual cycle, decreased libido, impotence.

The urinary system is hematuria, cystitis, marked impairment of kidney function.

Possible manifestation of the following allergic reactions: chills, reduced resistance to infection; In rare cases - hives, toxic epidermal necrolysis, Stevens-Johnson syndrome.

Dermatological reactions - skin rashes, photosensitivity, pigmentation disorders, acne, furunculosis.

At occurrence of any negative reactions of an organism to a medical product it is necessary to address immediately to the doctor.

Overdose

Overdose is dangerous for the hematopoiesis system. In these cases, the hydration of the body is shown. This can speed up the excretion of the active substance. Also prescribe to receive folic acid.

Storage condition and shelf life

We consider "Methodic" and "Methotrexate". The difference in the shelf life is also available.

In a dry dark place at a temperature not exceeding 25 degrees, these medicines are stored. Be sure to take them away from children. Sunlight and dampness are contraindicated. It is impossible to freeze them.

"Methodic" is suitable for 2 years from the date of production, "Methotrexate" - 3 years.

This distinguishes between "Methodic" and "Methotrexate". What is the difference?

In comparison with "Methodic", it is possible to distinguish some distinctive qualities of "Methotrexate". Side effects are possible, but, according to patients, are less frequent. Also, "Methotrexate" is produced in tablets, for many patients this form is more convenient.

So, we described in detail the use of the preparations "Methodic" and "Methotrexate". What is the difference, it is now clear.