Preparation "Pentas": instructions for use, analogues and reviews

In what dose do they prescribe Pentasa medication? Instructions for use, reviews and formulation of the drug are discussed below. Also in the materials of the article is information on the forms of release of this medication and its properties.

Composition, forms of medicament

There are several forms of release of the drug in question. Imagine them right now.

The drug "Pentasa" - tablets (500 mg, 100 mg) prolonged action. They are white with a grayish tinge, and also with numerous light brown patches, regular round shape, with a risk, facet and inscriptions on both sides.

The active element of this drug is mesalazine. Also included in the composition are inactive ingredients in the form of povidone, ethylcellulose, magnesium stearate, talc and microcrystalline cellulose.

In the sale of the drug "Pentasa" (tablets), a photo of which is presented in the article, comes in blisters, which are in packs of cardboard.

It should also be noted that the medication in question can be purchased in the form of suppositories, sustained-release granules and rectal suspension.

Pharmacology of a medicinal product

What is a Pentasa medication? The instruction for use states that this agent has an anti-inflammatory effect and is used to treat NNC and Crohn's disease.

The anti-inflammatory properties of this drug are manifested only with local use. This effect is due to the synthesis of leukotrienes and prostaglandins, as well as inhibition of lipoxygenase (neutrophilic) activity. In addition, this drug is able to slow the secretion of immunoglobulins with lymphocytes and inhibit the degranulation, migration and phagocytosis of neutrophils.

Features of the intestinal

Pentasa medication (tablets), the composition of which was presented above, shows a pronounced antibacterial activity against some cocci and Escherichia coli. It also has an antioxidant effect due to the ability of the active substance to bind to free radicals (oxygen) and to destroy them.

Proper use of this agent significantly reduces the risk of relapse in Crohn's disease, including in people with ileitis (with a long duration of the disease).

Principle of action of a medical device

How does Pentasa medication work? Instructions for use asserts that the therapeutic effect of this drug manifests itself immediately after the local contact of mesalazine with the intestinal mucosa.

After taking the oral drug, the tablet immediately decomposes into microgranules that act as separate forms and release the active substance, mesalazine, slowly. This ensures the effectiveness of the medication over the 12-finger to the rectum at any pH.

Pharmacokinetics of the agent

How is the absorption of Pentasa medication? Instruction for use informs that microgranules of decaying tablets reach the duodenum during the first 60 minutes.

Approximately 30-50% of the dosage taken is absorbed in the small intestine. The connection of mesalazine with plasma proteins is 43%, and the acids N-acetyl-five-aminosalicylic - 73-85%.

Mesalazine, as well as its derivatives do not penetrate the BBB. Cumulative properties of the drug manifest only when using high dosages (about 1500 mg per day).

Acetylation of mesalazine is exposed in the intestinal mucosa and liver. This substance is excreted in the urine, mother's milk and feces.

Indications for use of the medicine

In what cases can the drug "Pentas" (pills) be shown? The responses of specialists say that this medication is well manifested when:

• Nonspecific ulcerative colitis;
• Crohn's disease.

Prohibitions to the use of a medicinal product

Under what conditions can not use such a tool as "Pentasa"? Instructions (tablets and other forms of the drug have the same contraindications) speaks of the following prohibitions:

• Diathesis hemorrhagic;
• Blood diseases;
• Lactation period;
• Ulcer of the digestive tract;
• The last 2-5 weeks of pregnancy;
• Lack of glucose-6-phosphate dehydrogenase;
• Age up to two years;
• Renal failure is severe;
• Hypersensitivity to substance substances;
• Hepatic failure is severe.

With special care, the drug should be used in the first trimester of pregnancy, as well as with hepatic and renal insufficiency.

Pentasa medication: instructions for use

The choice of the dosage form of this drug depends on the localization of the main pathological process, as well as the extent of the intestinal lesion.

Suppositories of "Pentas" and suspension are prescribed for distal forms of the disease (proctosigmoiditis). In this case, candles are used three times a day for 500 mg.

How is the oral preparation of Pentasa (pills) prescribed? Instructions for use say that this kind of medication is recommended to be used only for common forms of diseases. For the prevention of recurrences with Crohn's disease, medication is used four times a day (1 g of mesalazine). With regard to the prevention of relapses of the NNC, in this case, the drug is prescribed three times a day for 500 mg.

When the disease worsens, the course of therapy should last 8-12 weeks. In this case, 400-800 mg of medication should be taken every day (three times a day).

In severe cases, an increase in daily dosage of up to 3-4 grams is possible.

Tablets "Pentas" should be taken immediately after a meal, without chewing and washing with plain water.

Side effects

In some cases, the drug in question causes the following side effects:

• Stomatitis, tremor of extremities, dry mouth, dizziness, nausea, depressive mood;
• A decrease in appetite, a feeling of rapid heartbeat, heartburn, shortness of breath with physical activity, vomiting;
• Hematuria, diarrhea syndrome, tachycardia, hepatitis, retrosternal pain;
• Increase in liver enzymes, fluctuations in blood pressure, pancreatitis, polyneuropathy;
• Crystalluria, tinnitus, proteinuria (protein secretion), migraine headaches;
• Oliguria, leukopenia, anuria (absence of urination), thrombocytopenia, formation of a nephrotic syndrome ;
• Hypoprothrombinemia, agranulocytosis, eosinophilia, anemia.

It should also be noted that against the background of taking this drug in the patient can be observed: olisgospermia, alopecia, photosensitivity, weakness in the limbs, lupus-like syndrome, decreased lacrimal fluid production, mumps.

Overdose with medicinal product

Overdose of the drug under consideration is manifested by increased drowsiness, nausea, gastralgia, vomiting and weakness throughout the body. To eliminate such symptoms requires a timely gastric lavage, as well as the appointment of laxatives and conduction of post-syndrome therapy.

Drug Interactions

Pentasa medication can slow the rate of absorption of cyanocobalamin. Also, mesalazine improves the effectiveness of uricosuric agents (including tubular secretion blockers).

It should also be noted that this drug increases the ulcerogenicity of glucocorticosteroids, weakens the effect of rifampicin, increases the toxicity of methotrexate and has a hypoglycemic effect on derivatives of sulfonylureas, spironolactone, sulfonamides and furosemide.

Special Information

If you miss a dose of mesalazine, it is recommended to take it along with the next or in the very near future. If several doses were missed, you should immediately consult a doctor. At the same time it is forbidden to stop treatment on your own.

Sometimes, against the background of the application of the drug in question, patients are observed to stain urine and contact lenses in a yellowish-orange hue.

In the process of treatment with mesalazine, constant medical control over the work of the patient's renal system is necessary. It is also necessary to regularly conduct urinalysis of the patient and his blood (during the course of therapy, and also after its completion).

The likelihood of the occurrence of adverse reactions against the background of taking this medication increases in those who are "a slow acetylator".

With the development of an acute syndrome of intolerance to the active ingredient, the "Pentasa" preparation is immediately canceled.

Similar medications and consumer reviews

Do you know what can replace the medicine in question? The doctor in charge should inform you about this. As a rule, the following drugs are considered to be analogues of this drug: Mesakol, Salosinil, Salofalk, Mezavant, Mesalazin, Asakol.

What do consumers say about this facility? According to their reviews, this medication is a highly effective medicine that can be purchased at any pharmacy. Patients claim that mesalazine is very good not only in therapy, but also in the prevention of Crohn's disease, as well as ulcerative colitis.