"Olanzapine": analogues, description of the preparation, instructions for use

For the treatment of schizophrenic and bipolar disorder , drugs based on olanzapine are used. There are many drugs with different trade names, but the same neuroleptic effect. One such medication is Olanzapine, its analogs contain a common active ingredient.

Description of the preparation

This antipsychotic agent is manufactured by ALSI Pharma ZAO in the form of light yellow tablets, the shape of which resembles a biconvex cylinder. There is a medicine in four dosages. Tablets of each dose differ externally with an engraving inscription. For the dosage of 0.0025 g there is an inscription "L", for the dose of 0,005 g the designation "FA20" is used. Tablets with 0.0075 g of olanzapine are engraved with "F20C", and with 0.01 g of the active component contain "N30C".

The structure of the drug form inactive ingredients, which include microcrystalline cellulose, monohydrate lactose, crospovidone filler, magnesium stearate. Their number increases two, three and four times, depending on the dosage of olanzapine.

Tablets of all doses are packaged in 7 pieces in blisters, which in a pack can be 4 or 8 pieces.

The "Olanzapine" application guide refers to antipsychotic neuroleptic drugs that show an affinity for serotonin, dopamine, muscarinic, adrenergic and histamine receptor formation.

The excitatory activity of the mesolimbic dopaminergic neuron decreases selectively, and there is little activity on the striatal nervous conduction that regulates motor functioning. The force in the conditioned defense reflex decreases, if low dosing is used, which does not cause cataleptic sleep.

The medicine "Olanzapine" increases the anti-anxiety effectiveness in the test task "anxiolytic" when it is performed. It removes the symptoms of negative and productive in the form of delusions and visions of hallucinogenic.

For what use

Olanzapine tablets act on schizophrenic conditions in adulthood in the acute stage, as a restraining and prolonged contrast treatment. They are used for psychotic discord with fruitful signs in the form of delusions, hallucinogenic visions and with negative symptoms such as emotional flattening, reducing socially significant actions, impoverishment of the speech apparatus.

The drug eliminates the recurrence of attacks with bipolar disorder, if the tablets successfully treat manic stages.

The preparation "Olanzapine" is prescribed for adults with bipolar affective disorders in the form of monotherapy or together with medicines containing ions of lithium or valproic acid. The drug is used to remove the acute form of manic or mixed action, which can manifest psychotic signs, and also have a rapid change in stages.

The drug is combined with fluoxetine medication under depressive conditions, which are associated with bipolar disorders.

Terms of use

"Olanzapine" medication instructions for use recommend taking a day from 0.005 to 0.02 grams orally, not adhering to the diet.

Schizophrenic state Adult patients are treated with an initial daily dosage of 0.010 g.

Acute mania of adults, characterized by bipolar disorder, is removed by daily amount of olanzapine in 0.015 g, which is administered once. If the tablets are used for restraining actions in conjunction with drugs based on lithium ions or valproic acids, a daily dose of 0.010 g is prescribed at a time.

Depressive processes in adulthood caused by bipolar disorder are removed with a daily amount of 0.005 g, which is combined with 0.020 g of fluoxetine substance. If necessary, it is possible to adjust the dosing of medicines.

For the elderly, patients with a possible threat of severe kidney or liver failure in chronic form, when there are risks associated with female sex, senile age characteristics, with the slowdown in olanzapine metabolism, the amount of its initial daily is reduced to 0.005 g.

Such means

The olanzapine medication has different trade names. They are produced by both domestic and foreign manufacturers.

Among Russian manufacturers, the company "Technology of medicines" LLC with the drug "Olanzapine-TL" is allocated, in the tablet form to 0,0025 grams with film coating.

Another domestic medicine is Olanzapine, manufactured by ZAO Severnaya Zvezda. There is a tablet form with a film coating and a dose of 0.005 g.

The Russian plant "Canonfarma Production" CJSC produces the preparation "Canon Olanzapin".

The Israeli medicine is the Olanzapine Teva medication manufactured by Teva Pharmaceutical Enterprises Ltd.

The Slovenian analogue is the "Zalasta Ku tab", in tablets of 0.015 g, designed for resorption. Produced by KRKA, Novo mesto. Also this plant produces the drug "Zalasta", in tablets.

The Swiss analogue is the drug Ziprexa in the form of lyophilizate in vials, from which a solution is prepared for intramuscular injection, with a dose of 0.010 g. In the form of tablets dispersible at 0,005 g, there is a preparation Ziprexa Zidis. They are produced by the company "Eli Lilly East SA". On the pharmaceutical market there is powdered medicine Ziprexa Adera with a dosage of 0.21 g.

The Polish company Polpharma JSC produces the drug "Normiton" in tablets with a shell coating to 0.005 g.

Olanzapine analogues are produced by the company Gedeon Richter under the name of the Parnasan tablet, and the Egilans medication was developed by the pharmaceutical company EGIS.

Description of the drug "Zalasta"

This antipsychotic agent refers to neuroleptics. Light-yellow tablets have a round, slightly biconcave form with dark impregnations. There are six dosages: 0.0025 g, 0.005 g, 0.01 g, 0.015 g and 0.02 g of olanzapine. Additional inactive components are considered to be cellulose, starch in pregelatinized form and corn, anhydrous aerosil ingredient, magnesium stearate.

For the labeling of the tablet form "Zalasta" the instruction for use describes the notation in the form of engravings indicating the dosage. Consumer packaging is a contour plate with 7 tablets. The pack can contain 4 or 8 such blisters.

This neuroleptic agent shows a wide pharmacological activity. An antipsychotic effect is associated with the blocking of receptor formations of the dopamine type. Sedative activity is caused by inhibition of adrenoreceptor sites, which form a reticular formation in the cells of the brain stem.

Antiemetic activity is possible when the D2-dopamine receptor site is stopped in the trigger zone, which is located in the vomiting center.

The hypothermic role is realized when the receptor formations of the dopamine type are blocked in the hypothalamus.

The "Zalasta" medication is recommended for use in schizophrenic manifestations. Tablets are able to actively maintain changes in clinical symptoms during long-term treatment of patients who have an initial positive effect on the drug.

The remedy eliminates episodic mania in an average or complex form. Tablets conduct preventive manipulation of repetition of insanity in bipolar disorder in people with manic episodes.

The drug is intended for oral single-use daily administration. Food particles do not affect the absorption of olanzapine, which allows the use of tablets at any time. If you refuse the medication, you should gradually reduce the dose.

For the treatment of schizophrenic disorders, an initial dosage of 0.010 g per day is used.

The episodes of mania begin to be treated with a daily dose of 0.015 g, which is administered in one application or 0.010 g when combined with other antipsychotics.

Preventing the repetition of bipolar disorder in the attenuation stage is carried out by initial dosing of the drug in 0.010 g per day. If people take this remedy for the elimination of episodic mania, then the same dose is used for restorative therapy. It is necessary to increase the amount of medication in case of new grouped or depressive episodes, as well as add treatment for mood disorders.

The daily dose of the drug to eliminate schizophrenic disorders, manic attacks and prevent repetition of bipolar disorder is used from 0.005 to 0.020 g, the value of which depends on the clinical parameters of the patient.

Elderly people to reduce the initial dosage to 0.005 g are not advised, but such actions are applied to patients aged 65 years, if there are risk factors.

Description of Olanzapine Canon

This antipsychotic medication of neuroleptic effect is available in tablet form with a shell coating. The shape of the tablet rounded with two convex yellow surfaces, the inner contents of the same color.

There are two dosages: 0.005 g and 0.01 g of olanzapine. The auxiliary ingredients include low-substituted hydroxypropylcellulose, calcium hydrogenphosphate, croscarmellose sodium, mannitol, magnesium stearate.

The shell film is formed by the yellow opacra of the second type, polyvinyl alcohol, macrogol, talc, titanium dioxide, iron oxide.

Treatment with the drug is prescribed for impairment, for restraining and long-term anti-relapse in adults with schizophrenic disorders.

The drug is administered by monotherapy, as well as combined combination with lithium-containing compounds in the strong form of manic or mixed bipolar affect disorder, which occur with psychotic expressions and with a rapid change of stages. The drug prevents repetition in people with bipolar disorders, if the drug helped to cope with the manic stage.

When treating adults with depression caused by bipolar disorder, as well as in a stable depressive degree, the medicine "Canon Olanzapine", an antipsychotic, can be combined with fluoxetine-containing drugs.

It is taken orally without diet. The instruction recommends taking into account the therapeutic dosage of the medicine, which is 0.005-0.020 g per day. The amount of this drug is selected for each patient separately, depending on the clinical signs.

Schizophrenic disorders of an adult patient Treated with an initial daily dosing of the drug in 0.010 g, which is taken at a time.
The state of acute mania of bipolar disorder is eliminated with a daily dosage of 0.015 g or 0.010 g of olanzapine combined with agents containing lithium ions or valproic acid.

Supportive use during bipolar disorder is carried out with an initial daily dosage of 0.010 g. If patients were taking the medication in an acute manic state, then the use of the drug in the same amounts should be continued.

Depressive disorders associated with bipolar disorder in adult patients are treated with a combination of 0.005 g of olanzapine and 0.020 g of fluoxetine drugs administered in the evening.

The antidepressant effect is manifested by the preparation in an amount from 0.006 to 0.012 g with an average daily dose of 0.0074 g. The dose of fluoxetine medicines ranges from 0.025 to 0.030 g. If necessary, it may be possible to review the dosage of both drugs.

The therapeutic stable form of depression is removed by combining 0.005 g of olanzapine and 0.02 g of fluoxetine agents administered once in the evening.

Description of the drug Ziprexa

This neuroleptic is made in tablet form with a coating shell. There are four dosages of the drug: 0,0025, 0,005, 0,0075 and 0,010 g each, which have corresponding designations on the surface of "LILLY 4112", "LILLY 4115", "LILLY 4116", "LILLY 4117".

Inactive components in the form of sugar, dairy, hydroxypropyl cellulose, crospovidone, microcrystalline cellulose, magnesium stearate formed the structure of the drug.

Tablets are packaged in blisters of 7 pieces, the pack contains 4 contour packs.

There is also a lyophilized form intended for the manufacture of intramuscular solutions. Yellow liquid with a dosage of 0.01 g is packaged in vials. Lactose monohydrate and tartaric acid are considered inactive components.

The medicine has an antipsychotic effect.

The active ingredient of the drug behaves like a ligand that binds to serotonin, dopamine, m-choline, H1-histamine, and alpha1-adrenoreceptor receptors. Olanzapine has a selective effect on the limbic system.

Ziprexa recommends using the instructions for use in severe stages of schizophrenic and psychotic disorders, which are accompanied by obvious signs of delusions, hallucinations, intellectual, hostile, suspicious moods or negative type in the form of emotional and social alienation, disorders of the speech apparatus. The medication is prescribed to eliminate secondary affective symptoms caused by schizophrenic disorders.

The Ziprex tablets are recommended for oral use at any time. At the beginning of treatment, a single dosage is 0.010 g. Subsequently, the daily dosage ranges from 0.005 to 0.020 g, which is associated with a symptomatic picture.

Intramuscularly injected medication, if you urgently need to stop the excitation of psychomotor character in people who have schizophrenic, bipolar affective disorders and dementia.

Before use, the lyophilizate is diluted in 2.1 ml of an injectable aqueous medium. It turns out a transparent solution with a yellow tinge.

Nervous emotional excitement of schizophrenic and bipolar disorder is removed by a single dosing in 0.010 g.

Taking into account the therapeutic picture of the patient, repeated administration of a dosage of 0.010 g is carried out 120 minutes after the first application, and the next 0.010 g is consumed 240 minutes after the second application.

For further treatment with the drug "Ziprexa" go to its tablet form with a dosage of 0.005 to 0.020 g.

Agitation with dementia is removed with a single intramuscular dose of 0.0025 g. Given the clinical picture of the patient, a second dose of 0.005 g is given after 120 minutes from the first application.

Description of the drug "Adera Ziprexa"

There are medicines "Olanzapine" analogues, which are available in the form of a powder of 0.405 grams of olanzapine in bottles with a solvent, a syringe and a needle.

The drug "Adera Ziprexa" refers to antipsychotic drugs of neuroleptic activity.

The medication reduces impairment, is used for restorative and prolonged contrast treatment of schizophrenic and psychic changes with symptoms highly productive in the form of delusions, hallucinogenic visions and negative with emotional flattening, depletion of the speech apparatus.

The medication is treated with strong manic and combined bouts of bipolar disorder, during which a psychotic manifestation and a rapid change in stages are possible.

The initial daily dosage is used at 0.010 or 0.015 g. The daily amount of the drug is selected for each patient separately, given the clinical picture. A therapeutic daily dose of 0.005 to 0.020 g

An increase in dosing is possible only if the results of the surveys are available. The increase in the amount of the drug is carried out in stages, every 24 hours.

Patients elderly, in the presence of insufficient work of the kidneys and liver, the initial daily dose is prescribed to 0.005 g.

Cost of analogues

A wide range of neuroleptic drugs allows you to choose the right drug, which is suitable for quality and cost. Medicines "Olanzapine" price is relatively small. Packaging of tablets can be bought for 290 rubles.

Medication "Zalasta" price is from 1370 rubles.

An expensive means are considered to be Ziprex Zidis tablets. For the packaging of the drug you need to give 2370 rubles. The cost of the analogue "Ku-Tab Zalasta" is 1075 rubles.

The price of the reviews is negative for the medicine Ziprexa. A packet with 28 tablets costs 4760 rubles.

For unprotected layers of the population will be available medicine "Olanzapine", the price of which is several times less.

Patient's opinions

About the medicine "Olanzapine" reviews can be heard both positive and negative. Many drugs help to cope with depression and reduce the number of negative thoughts after a few days of admission. He is considered one of the strongest neuroleptics, which calms patients, eliminates fears and anxieties.

Among the disadvantages are the undesirable consequences that are associated with the slowing of the metabolism, resulting in increased body weight of the patient. There is drowsiness, asthenic syndrome, dizziness, pressure drop arterial orthostatic type, develop swelling of soft tissues and dry mucous membranes.

For some patients, even a small dose of medication is a powerful sleeping pill, from which they sleep 12 hours a day.

The human body is individual, therefore, tablets act differently for each patient. To find the right remedy, you need a doctor's consultation.