"Latran": instruction manual, reviews, analogues

Among drugs that fight with such a symptom as nausea and vomiting, it is worth noting Latran. The drug's instruction contains all the necessary information for patients: how to take the drug and in what cases, it is compatible with other medications and what contraindications the manufacturer claims.

In what cases is Latran appointed?

Nausea and vomiting as a violation of the digestive system are one of the most common symptoms. To deal with it, it is important first to find out what caused it. Unlike most anti-emetics, Latran can be taken not only orally, but also parenterally through a tablet or injection form of release.

The specificity of the indications for taking this medication makes it responsible to apply it. According to the instructions, "Latran" is prescribed for patients undergoing antitumor treatment, implying the inclusion of chemotherapy, ionizing radiation sessions. Prescribe the drug and in case of emergency elimination of the withdrawal syndrome, i.e. With the most dangerous alcohol intoxication. To blunt the emetic reflex appoint a remedy after a surgical operation. It is important to consider that the drug is not used for chronic disorders in the digestive system (for example, nausea with gastritis, duodenitis, pancreatitis).

How does the medicine work on the human body?

If you believe the instructions for use, injections "Latran" are immediate. The principle of the drug is based on blocking the so-called serotonin receptors. If this hormone is produced under the influence of artificially created conditions, for example, with radiation therapy, the body is not always able to cope with the task of its suppression independently. In addition, this drug, gently affecting the digestion, inhibits its processes, slows down peristalsis. A plus in the use of the drug is the lack of influence of its components on the work of the nervous system. In this vein, Latran is absolutely safe:

• Produces a slight sedative effect;
• Does not reduce efficiency;
• In no way prevents a normal reaction while driving a car;
• Do not provoke drowsiness.

What is included in the antiemetics?

Ondansetron hydrochloride dihydrate is the active substance in the composition of the drug, which helps to achieve anti-abstinence and antiemetic effect. As already noted, the drug has two forms of release - tablets and ampoules. The instructions for the use of "Latran" indicate the capacity of the active component in each unit. In one tablet, for example, contains 4 mg of ondansetron, in addition to which the composition of the drug includes:

• Silicon dioxide;
• magnesium;
• starch;
• Castor oil.

Ampoules in volume of 2 and 4 ml are released in a package of 5 pieces. The solution of transparent color consists of the active substance and sodium chloride, water for injection. Self-treatment "Latron" is unacceptable. The decision on the dosage, the method of taking and the duration of the anti-emetic therapy course is taken by the doctor.

How correctly to drink tablets?

Most often, with mild and moderate severity of withdrawal, mild nausea after taking chemotherapy drugs, radio patients are recommended to take Latran tablets. In the instructions for use, it is also noted that the drug can be used orally to prevent vomiting and nausea after surgery. The drug is drunk before anesthesia. The dosage of tablets is calculated by a specialist based on the age of the patient:

• Adults are recommended 8 mg of the drug 1 hour before the manipulation (2 tablets).
• Children - not more than 4 mg of medicine (1 tablet).

If there is nausea after a session of antitumor treatment, the drug is drunk in a similar scheme - for adults at 8 mg per hour before the procedure. If the symptoms are not removed, after 2 hours after the end of chemotherapy or radiation, 2 pills are drunk again. At the end of the course of oncology, Latrana can not be abolished abruptly, therefore it continues to be drunk for 5-7 days. For adults, the daily norm is 16 mg ondansetron, for children 8 mg. In the course of treatment it is important to provide the patient with a copious drink.

Preparation of solution for injection

According to the instruction, injections of "Latran" are done both intramuscularly and intravenously. Before administration, a solution of the drug is prepared. By the way, during the first 24 hours after opening the ampoule, the drug is considered to be acceptable for use under proper storage conditions (at a temperature of +2 to +7 degrees). The recommended liquid cleaning fluid for physicians is:

• Saline (sodium chloride);
• Ringer's solution;
• Potassium chloride 0.3%;
• Glucose solution 5%.

How often to stab Latran?

Further dosage is determined depending on the degree of nausea after specific antitumor treatment. The maximum allowed daily dose is 32 mg of the active ingredient. In the case of relatively low emetogenicity, Latran is injected in an amount of 8 mg before the procedure. With a pronounced emetic reaction to oncotherapy, the remedy is stabbed twice more after being manipulated with a two-hour break.

It is possible to spray the preparation. Allowed as a daily, and a 15-minute infusion (dropper) with the introduction of 24 mg of the drug, previously diluted. Patients under the age of twelve Latran are usually administered intravenously at a rate of 0.1 mg per 1 kg of body weight, with a single injection of more than 4 mg.

It is worth noting that with liver damage, the amount of active substance delivered during the day should not exceed 8 mg.

Can I combine with other medicines?

As precautionary measures before use, it is advisable to study the instruction for the Latran tablets. Often doctors forget to warn the patient that the drug is incompatible with the intake of other active substances. For example, it is dangerous to drink Latran together with antidepressants, papaverine and barbiturates. Such a drug "cocktail" not only reduces the effectiveness of the drug, but it is fraught with serious consequences for the body - it can lead to bronchospasm and pulmonary edema. Also it is impossible to drink Latran simultaneously with ketoconazole, omeprazole, cimetidine - these active substances accelerate the removal of ondansetron from the body, not allowing it to act fully. When combined with glucocorticosteroids, the therapeutic efficacy of an anti-emetic drug, on the contrary, becomes higher.

Can there be side effects?

The instructions to Latran also contain information about possible side effects. Despite the effectiveness of providing assistance and overcoming emetic pushes, the drug often causes a short discomfort, which manifests itself:

• Dizziness and cephalgia;
• Muscle cramps;
• Blurred vision;
• Intestinal disorder, constipation;
• Dry mouth or, conversely, increased salivation;
• Tachycardia, arrhythmia, pain in the sternum;
• Rashes on the body, hives;
• A sharp drop in blood pressure.

In case of an overdose, it is extremely important to rinse the stomach with a patient and consult a doctor. To suspect an overdose can be due to pronounced side effects.

The main contraindications to the use of Latran

The manufacturer categorically does not recommend taking medication if there is at least one contraindication among those indicated in the instructions. "Latran" with caution is taken with a tendency to develop allergic reactions, and with individual intolerance of one of the components in the drug is replaced by a more suitable analog. In addition, the drug is not prescribed for pregnant and lactating women, since ondansetron has the property of penetrating into breast milk. Contra-indicated "Latran" and in early childhood (up to 24 months). Despite the fact that this drug is prescribed to prevent emetic reaction in the postoperative period, during the surgical treatment of the abdominal cavity the drug is rarely prescribed.

How long and in what conditions should I save the medicine?

Measures for the precaution and storage of the drug are not significantly different from those that apply to most other medications. The instructions for the use of "Latran" indicate a three-year shelf life from the date of manufacture at a temperature of +25 degrees. It is important to remove the medicine away from small children, protect from exposure to the sun. The cost of the drug in comparison with imported analogs is affordable. On average, the price of Latran in Russia does not exceed 350 rubles per package.

Brief description of antiemetic analogues of the preparation

Among the alternatives to the drug is worth noting no less effective, but more expensive medicines:

• "Domegan" - an antagonist of serotonin receptors, is also available in the form of suppositories, syrup. It is accepted according to the same scheme as "Latran". The instruction on the use of the analogue does not have any significant differences.
• "Lazaran VM" - the drug of central action, requires caution in cases of kidney failure, side effects in patients are more likely to be constipated.
• Zofran is a medicine based on ondansetron. Tablets for resorption and syrup have a pleasant strawberry taste. Because of the presence of aspartame in the composition of "Zofran" should be cautious patient with phenylketonuria. The cost of this drug is almost 5 times higher than the price of Latran.
• "Emetron" - is used together with "Dexamethasone" to increase the effectiveness of the active substance. Tablets are not prescribed for patients with lactose intolerance.

What do the patients themselves say about this antiemetic?

If you take into account the feedback and instructions for using the analogues of Latran, you can say with confidence that the preparations are largely similar to each other and produce an almost identical therapeutic effect. Despite the fact that responses to this drug are extremely rare, it is not difficult to make a conclusion about the effectiveness and expediency of its use. The majority of patients fighting with oncology are more tolerant of irradiation and chemotherapy sessions.

With nausea and vomiting caused by alcohol abstinence, Latran helps to improve the general well-being of the addict. To achieve the necessary therapeutic effect, it must be taken with the adsorbent.

In the responses, the patients also indicate that the priority way of taking Latran is intravenous. In this case, the tablet form of the drug is considered more convenient: many keep the medicine at hand in case of repeated attacks of nausea. Symptoms are removed quickly, and after half an hour the patient already "wakes up" his appetite.

Accepting Latran according to the instructions, the patient minimizes the chances of developing side effects. In addition, you can not buy the drug in a pharmacy without a prescription. Not having a doctor's appointment on hand, you can buy "Cerukal" or "Metoclopromide" - antiemetic drugs, the principle of which is based on the blocking of dopamine receptors. Patients in their reviews note that Latran is superior to these drugs due to the onset of a faster therapeutic effect.

Many people take ondansetron in the mornings in order to prevent nausea and vomiting, but forget that according to the instructions, the drug Latran can be used no longer than a week. Often a longer course provokes side effects. In general, patients who underwent antitumor treatment successfully coped with nausea and vomiting due to Latran. Negative reviews of the drug were more often left by those who ignored the rules of its use, engaged in self-medication.