"Indapamide": analogues. "Indapamide": reviews of doctors

What is the drug "Indapamide"? Analogues of this tool, its instructions, side effects and indications for use will be presented later. In addition, from this article you will find out whether this medication has contraindications, what to do in case of an overdose, how it should be taken, whether it can be combined with other drugs, and what specialists think about it.

Composition of the medicinal product and its form of release

In what form does this drug go on sale? In the pharmacy it can be found only in the form of biconvex tablets, covered with a white film shell.

What active ingredient does the "Indapamide" medication include? Analogues of this drug (most of them) and the drug itself contain an active ingredient such as indapamide. With regard to excipients, the tablets include the following elements: lactose monohydrate, crospovidone, povidone K-30, magnesium stearate, talc and sodium lauryl sulfate.

Pharmacological action of the drug

What are the properties of the drug "Indapamide", the price of which is presented at the very end of the article? This drug refers to an antihypertensive drug. In other words, it is a diuretic and a vasodilator.

According to its pharmacological properties, the drug is very similar to thiazide diuretics and is taken when the reabsorption of sodium salts that occur in the cortical segment of the Henle loop is violated. It is capable of increasing the release of chlorine, magnesium, sodium and potassium ions together with urine.

What is the purpose of the medication Indapamide? Analogues of this drug and the drug itself has the ability to block "delayed" calcium channels selectively, increase the elasticity of the walls of the vessels and reduce the overall vascular resistance (peripheral).

The intake of this drug reduces the hypertrophy of the heart, or rather his left ventricle. It has no effect on the volume of lipids in the blood, as well as on carbohydrate metabolism, including in people with a disease such as diabetes mellitus.

This drug reduces the sensitivity of the vascular wall to angiotensin II and noradrenaline, reduces the production of stable and free oxygen radicals, stimulates the synthesis of prostaglandin E2.

After applying the drug, the hypotensive effect develops towards the end of the first week of therapy. In this case, it persists for 25 hours (after taking one tablet)

Pharmacokinetics of the drug

Where is the medication indapamide taken? Instruction, reviews of experts say that after taking the drug inside it is almost completely and immediately absorbed from the digestive tract. According to pharmacists, its bioavailability is 93%. Simultaneous intake of food slightly slows the rate of absorption, although it does not affect the volume of the absorbed active element.

The maximum concentration of the active component in the blood plasma is reached approximately 2 hours after taking one tablet. The half-life of the drug is 14-25 hours. The connection with blood proteins is about 79%.

This drug passes well through the histohematological barrier (including the placental barrier). It also penetrates into the mother's milk.

Metabolism of the drug substance is carried out in the liver. It is excreted by the kidneys (in the form of metabolites) in an amount of 60-80% and 20% by the intestine.

Indications for use of the medicinal product

In what cases is the patient assigned the drug "Indapamide"? Indications for the use of this tool include only one pathological condition of the patient. This is hypertension. In addition, the medication can be prescribed with sodium and water retention in the body. As a rule, this condition is often observed in chronic heart failure.

Contraindications to the use of medicinal product

Now you know what the medicinal product "Indapamide" is intended for (indications for the use of this remedy were presented just above). However, it should be noted that this medication has contraindications. These factors include:

• Intolerance to lactose by the patient;
• Period of pregnancy;
• Galactosemia;
• Hypokalemia;
• Syndrome of malabsorption of galactose or glucose;
• Lactation period;
• Simultaneous use of medications that are able to extend the QT interval;
• Severe renal failure (or anuric stage);
• Age of a person under 18 years of age (safety and efficacy of the drug in the treatment of children not established);
• Expressed hepatic, including with encephalopathy, insufficiency;
• Hypersensitivity to the drug and other sulfonamide derivatives.

Cautious use of medicament

Many people are interested in: is it necessary to buy a prescription for the preparation of the drug "Indapamide"? In fact, before applying any medication, it is recommended to consult a doctor - only a specialist after the examination and on the basis of the results of the tests will be able to build a competent treatment regimen. As for our case, we note that the agent under consideration with special care is prescribed for people with diabetes, gout, and also those patients who are allergic to derivatives of sulfonamides.

In addition, the drug should be taken with caution in cases of liver, kidney and water-electrolyte imbalance.

During the therapy, the doctor must constantly monitor the level of electrolytes in the patient's blood (potassium, sodium, calcium).

The preparation "Indapamide": instruction on application, expert reviews

According to the attached instructions, this medication should be taken orally regardless of eating. The tablet should be washed down with a sufficient amount of clean water.

How to take Indapamide? According to experts, this drug is better absorbed from the digestive tract only early in the morning. Therefore, it is recommended to take it exclusively at this time of day.

The dosage of the drug should be 2.5 mg (i.e., 1 tablet) per day. If after 4-8 weeks of therapy the desired effect has not been achieved, then the amount of medication should not be increased (although often the doctors do exactly that). This fact is due to the fact that at a higher dosage the risk of side effects increases. Instead, drug therapy should include another antihypertensive drug that is not a diuretic.

How to take "Indapamide" in this case? With the simultaneous administration of two drugs, the dose of the drug under consideration remains the same, that is, 2.5 mg per day (early in the morning).

Cases of overdose: symptoms, treatment

What will happen if you take a large amount of the drug "Indapamide"? The doctors say that in such cases the patient has nausea, weakness and vomiting. In addition, the patient is disturbed by water-electrolyte balance and the work of the digestive system. In some cases, the patient has a strong lowering of blood pressure and depressed breathing. In patients with cirrhosis of the liver, a hepatic coma is possible .

How to treat? In case of an overdose, the patient should be washed out of the stomach, adjusted the water-electrolyte balance, and also apply symptomatic therapy.

Side effects after taking medication

Can negative reactions occur after taking the drug "Indapamide"? There are side effects of this drug. Let's list them right now.

• Digestive system: gastralgia, nausea, abdominal pain, vomiting, anorexia, constipation, dry mouth, pancreatitis, diarrhea, hepatic encephalopathy.
• Respiratory system: sinusitis, cough, rhinitis and pharyngitis.
• Nervous system: insomnia, asthenia, muscle spasms, nervousness, general weakness, anxiety, headaches, fatigue, vertigo, dizziness, depression, drowsiness, irritability, malaise and tension.
• Urinary system: nocturia, frequent infections and polyuria.
• Heart and blood vessels: arrhythmia, orthostatic hypotension, palpitations and changes in the ECG (ie hypokalemia).
• Allergies: hives, rashes, hemorrhagic vasculitis and itching.
• The hemopoietic system: thrombocytopenia, hemolytic anemia, leukopenia, bone marrow aplasia and agranulocytosis.
• Laboratory indicators: glucosuria, hyperuricemia, increased urea nitrogen in blood plasma, hyperglycemia, hypercreatininaemia, hypokalemia, hypercalcemia, hyponatremia and hypochloraemia.
• Other: exacerbation of systemic lupus erythematosus.

Interaction with other medicines

The drug "Indapamide", whose action is aimed at lowering the pressure, is not recommended to be taken together with cardiac glycosides, as the likelihood of digitalis intoxication increases. If you use this tool with calcium and metformin, then the patient can develop hypercalcemia and aggravate lactic acidosis.

Simultaneous reception of the drug with GCS, NSAIDs, sympathomimetics and tetracosactide lower the hypotensive effect of the former. As for the "Baclofen", with him, on the contrary, it is getting stronger.

The combination of the drug with potassium-sparing diuretics is effective in a small number of patients. However, the possibility of developing hyper- or hypokalemia, especially in patients with renal insufficiency and diabetes mellitus, is not ruled out.

ACE inhibitors can increase the risk of arterial hypotension and acute renal failure.

The work of the kidneys can be disrupted with the simultaneous use of iodine-containing drugs in high doses.

Neuroleptics and imipramine antidepressants help to increase the hypotensive effect and increase the risk of orthostatic hypotension.

Special instructions for the use of the medicinal product "Indapamide"

In what cases should the patient's blood picture be monitored after the administration of Indapamide? The doctors say that this medication can change the amount of creatinine and potassium ions in those patients who take laxatives, cardiac glycosides, as well as in people over 60 years old.

When using this tool, specialists are advised to systematically monitor the concentration of sodium, potassium and magnesium ions in the blood plasma, as patients can develop electrolyte disorders. It is also necessary to monitor the pH, the concentration of uric acid, glucose and residual nitrogen.

Particular control should be given to patients with cirrhosis of the liver (with severe edema or ascites), as well as with heart failure and ischemic heart disease.

The high-risk group includes patients with an increased QT interval on the ECG (may be congenital or develop against a backdrop of any pathology).

The first measurement of the concentration of potassium ions in the patient's blood is recommended in the first week of treatment.

Particular attention should be paid to patients with diabetes mellitus. In particular, it is necessary to observe the level of glucose in the blood, especially if the person is diagnosed with hypokalemia.

Patients taking this medication should compensate for the loss of water by consuming a large amount of liquid per day. Moreover, at the very beginning of therapy they need to monitor the work of the kidneys.

One can not help saying that the drug "Indapamide", analogues of which will be presented below, can give a positive result during the doping control.

Patients with hyponatremia and hypertension should stop taking diuretics 3 days before the use of angiotensin converting enzyme inhibitors. The treatment can be resumed a little later.

When administering Indapamide, specialists should note that sulfonamide derivatives can easily cause an exacerbation of a disease such as systemic lupus erythematosus.

To date, the safety and efficacy of the drug in the treatment of young children and adolescents is not established.

In individual cases, individual reactions are possible that are associated with changes in blood pressure. Typically, this occurs at the very beginning of therapy, as well as when using another antihypertensive drug. As a result, the ability to control the machine and work with other mechanisms may decrease, which requires increased attention.

Reviews of specialists and patients about the drug

Now you know what the "Indapamide" product is. Reviews, the price of this medication will be presented right now.

Experts say that this medicine is coping well with the task. It effectively lowers blood pressure, and also acts as a diuretic.

Reviews about the drug "Indapamide" indicate that after its application, left ventricular hypertrophy decreases, and its hypotensive effect is manifested even in those patients who are on hemodialysis.

As for negative statements about the said remedy, they are most often associated with the manifestation of a large number of adverse reactions. However, it should be noted that such effects are observed only in those who have exceeded the prescribed dosage of the drug or took it, despite the existing contraindications.

Price and analogues of the medicinal product

How much does the drug "Indapamide" cost? The price of this medication may be different (depending on the manufacturer and the mark-up of the pharmacy network). However, on average, this drug can be purchased for 95-100 Russian rubles (for 30 tablets).

But what if the patient could not find the medication "Indapamide"? Analogues, whose price is also not very high, are sold in virtually every pharmacy. Such medicines include the following: Indapamide Retard, Acrypamide, Indapamid-Teva, CP-Indamed, Acrympide Retard, Ravel SR, Acutter-Sanovel, Retapres, Arindap "," Lorvas "," Arifon "," Pamid "," Arifon retard "," Tensar "," Ipres Long "," Vero Indapamid "," Indipam "," Indap "," Indyur "," Indapamid-Verte "," Ionik "," Indapamid retard-Teva "," Inpadres "," Indapamid Sandoz "," Ionik retard "," Indapamid-OBL "," Indapamid Stada "and so on.

Take these funds at their own discretion and replace them with the medication "Indapamide" is strictly prohibited. Only the doctor should prescribe them, and only after a medical examination. Also, before taking these medications, you should read the attached instructions.

Conditions for storage of the preparation and its shelf life

Store the medicine in a dry and dark place, which is not accessible to young children. The temperature of storage of the drug should not exceed 25 degrees. The expiration date is 3 years. After this period, it is strictly forbidden to take the medicine.