"Glibenclamide": instructions for use, form of release, photo, analogues

What is the medicine "Glibenclamide"? Instructions for use, form of release, analogs and indications for taking the drug are indicated below.

Composition, packaging, form of release of the product

In what form is the medicine "Glibenclamide" produced? The instruction says that this product is available in the form of tablets, which are placed in plastic containers (contour cells) and boxes of cardboard, respectively.

The composition of the drug in question includes 5 mg of glibenclamide, as well as auxiliary ingredients such as potato starch, lactose monohydrate, magnesium stearate, croscarmellose sodium, indigo carmine E 132, silicon dioxide dioxide and povidone 25.

Action of the medicinal product

What is the drug "Glibenclamide"? Instructions for use say that this tool, which shows a hypoglycemic effect in healthy people and patients with type 2 diabetes.

The effectiveness of this medication is due to its ability to increase insulin secretion by the beta-cells of the pancreas due to their stimulation. According to experts, this effect of the drug is enhanced by the influence of glucose.

Kinetic features of oral preparation

What pharmacokinetic features are characteristic of the drug "Glibenclamide"? Instructions for use asserts that after oral administration of tablets, their active substance is quickly and almost completely absorbed from the digestive tract.

Simultaneous consumption of food leads to a decrease in the concentration of glibenclamide in blood plasma (compared with fasting). The association of this component with albumin is more than 98%.

In the patient's liver, glibenclamide is converted into the following metabolites: 3-cis-hydroxy-glibenclamide and 4-trans-hydroxy-glibenclamide. They are equally derived by the kidneys and with feces.

The average half-life of the drug is 2-3.5 hours. In people with impaired liver function, this indicator is significantly reduced.

Indications for use of the medicinal product

In what cases can the patient receive Glibenclamide tablets? This tool is recommended for patients with type 2 diabetes, when there is no way to compensate for hyperglycemia with a strict diet, as well as physical activity or weight loss.

Prohibitions to use

Are there any contraindications to the drug Glibenclamide? Instruction for use states that this remedy should not be given to patients when:

• Extensive burns;
• Hypersensitivity to the active ingredient, as well as thiazide diuretics or sulfonamides;
• Ketoacidosis;
• Diabetic comatose and precomatous conditions;
• Development of hypoglycemia;
• Surgical interventions and other injuries;
• Paresis of the stomach and intestinal obstruction;
• Pregnancy;
• Diabetes mellitus of the first type;
• Breastfeeding.

"Glibenclamide" medication: instructions for use

The drug in question should only be prescribed by an experienced physician. Admission of this medication should always be combined with a strict diet. Only in this case it will be effective. The mode of dosing depends on the results of the analysis of the patient (blood sugar level, indicators obtained as a result of urinalysis, etc.).

So how should you take Glibenclamide? Therapy starts with this minimum dose. This is especially true for people with a tendency to hypoglycemia and body weight less than 50 kg.

Usually the first dosage of the drug is 0.5-1 tablet per day. This corresponds to 2.5-5 mg of the active substance. If the drug is ineffective, this amount can be gradually increased to three tablets per day, which corresponds to 15 mg of the active ingredient. Do this with an interval of several days to one week, until the desired result is achieved.

How to transfer the patient from another drug to the drug "Glibenclamide"? The use of medication in this case should be carried out very carefully. First, the patient is prescribed 0.5 tablets per day, and then gradually increase the dose to the most effective.

Elderly, as well as weakened patients or patients with malnutrition and impaired liver or kidney function, the maintenance or initial dosage of the drug should be minimized as much as possible due to the likely development of hypoglycemia. Also, the issue of correcting the dose of the drug should be addressed with a decrease in the patient's body weight or with a change in his habitual way of life.

Method for taking hypoglycemic tablets

How is Glibenclamide used? Instructions for use (the photo of the drug is presented in this article) states that the tablets should be taken before meals, washed down with a glass of filtered water and not chewed.

At a daily dosage equal to 2 tablets, the drug is recommended to be divided into 2 divided doses (morning and evening) in a ratio of 2: 1.

It is extremely important to use this medicine at the same time. If you miss a drug, you are not allowed to take the tablet with the next one.

The duration of therapy with this drug depends on the course of the disease. Throughout the course of treatment, it is required to conduct a constant monitoring of the patient's metabolic state.

Side effects

The drug "Glibenclamide", the analogues of which are listed below, can cause the development of undesirable reactions affecting the work of the nervous, endocrine, peripheral and digestive systems, and hematopoietic. In this regard, the patient may experience such side effects as nausea, hypoglycemia of varying severity, impaired liver function, diarrhea, headache, cholestasis, weakness, dizziness and fatigue.

It should also be noted that against the background of taking this remedy, dermatological and allergic reactions in the form of photosensitivity, itching, skin rashes and other unpleasant symptoms may occur.

Cases of an overdose of a hypoglycemic agent

What are the symptoms when taking higher doses of the drug Glibenclamide? The guideline states that hypoglycaemia may develop in patients with an overdose, possibly accompanied by weakness, hunger, headache, anxiety, excessive sweating, dizziness, muscle tremor, palpitations, cerebral edema, visual and speech impairment.

Therapy of such conditions assumes an urgent intake of glucose-containing easily assimilated products. For example, fruit juice, sugar, corn syrup, sweet hot tea or honey.

In more severe cases, the patient is administered a 50% solution of glucose, Dextrose, Glucagon or Diazoxide. Also, special control of the level of glycemia, creatinine, urea nitrogen, electrolytes and pH determination is required.

Interaction with other medical devices

The combination of the drug in question with systemic antifungal drugs, tetracyclines, fluoroquinolones, chloramphenicol, MAO and ACE inhibitors, H2 blockers, Clofibrate, beta-blockers, probenecid, bezafibrate, Paracetamol, anabolic steroids, ethionamide, allopurinol, pentoxifylline, cyclophosphamide , "Reserpine", insulin and sulfanilamide is capable of potentiating hypoglycemia.

Concurrent use of the drug with phenothiazines, thyroid and glucocorticoid hormones, barbiturates, estrogens, diazoxide, gestagens, glucagons, lithium salts, adrenomimetic agents, saluretics and nicotinic acid derivatives may weaken its hypoglycemic effect.

Such drugs that acidify urine (including ammonium chloride, calcium chloride, ascorbic acid), can enhance the effect of the drug in question.

The use of "Glybenklamid" with "Rifampicin" accelerates inactivation, and also reduces the effectiveness of the former.

Special Information

The hypoglycemic agent under consideration should be carefully prescribed to patients suffering from renal and hepatic dysfunction, as well as pathological work of the thyroid gland and adrenal glands, fever and chronic alcoholism.

For the conduct of normal treatment requires regular monitoring of the glucose level in the patient's blood, as well as its excretion.

If, against the background of taking the medicine, the patient develops hypoglycemia, then the sugar is prescribed inside (if the person is conscious). With a loss of consciousness, glucose is administered intravenously, and glucagon is administered subcutaneously, intramuscularly or intravenously. After the patient regains consciousness, he is immediately given food saturated with carbohydrates in order to avoid the repeated development of hypoglycemia.

Cost and analogues (synonyms) of the means

Select the analogues of this drug should only an experienced specialist. To similar medicines doctors carry the following: "Maninil", "Manin", "Maniglid", "Betanaz" and "Antibes".

It should also be noted that pharmacies often sell synonyms for this product. Most often they are used as: Glidanil, Glibeks, Glybamide, Gilemal, Glybomet, Glibenclamide. The dosage of these drugs is selected individually.

As for the price of the drug "Glibenclamide", it varies between 280-360 rubles.

Reviews about the medicine

Now you know what the drug "Glibenclamide" is. Instructions for use, analogues and form of this product are described above.

What does consumers say about this drug? As a rule, all reports about it are reduced to discussing some or other therapeutic regimens that are recommended for people with diabetes.

Consumers say that most often "Glibenclamide" is used by them as monotherapy. Although there are also patients who prescribe the drug in combination with other hypoglycemic drugs.

According to the doctors, the purpose of the medication in question requires an individual approach. In doing so, the specialist should familiarize himself with all the results of the analyzes and other studies. To take "Glibenclamide" to patients at their own discretion is extremely dangerous for health and life.