"Felodip": instructions for use, reviews. Drug analogues

Why is the preparation "Felodip" necessary? The instructions for using this medication will be described in detail in the article presented. Also from it you will learn about what this medication is prescribed for, what side effects it has, whether it has contraindications, how much it costs, what analogues it has and so on.

Composition of the medicament, its form of release and packaging

In what form can you find the drug "Felodip" in the pharmacy? The instruction on the use of this medicine says that it is only available in the form of long-acting tablets. And a different dosage of this drug has a different shell:

• Tablets of yellow color in the form of lentils without any smell are indicated by the figure 2.5. The active element of this drug is felodipine in an amount of 2.5 mg. The excipients of this drug are lactose monohydrate, hypromellose, microcrystalline cellulose, red iron oxide, povidone, titanium dioxide, propyl gallate, yellow iron oxide, magnesium stearate, propylene glycol, silicic anhydrous colloid, talc. In the sale of this drug comes in blisters of 10 tablets, which are placed in cardboard packs.
• Tablets of light pink color in the form of lentils without any smell are indicated by the number 5. The active element of this drug is felodipine in an amount of 5 mg. Excipients of this drug are lactose monohydrate, hypromellose, microcrystalline cellulose, red iron oxide, povidone, titanium dioxide, propyl gallate, yellow iron oxide, magnesium stearate, propylene glycol, silicon anhydrous colloid, talc. In the sale of this drug comes in blisters of 10 tablets, which are placed in cardboard packs.
• Tablets of red-brown color in the form of lentils without any smell are indicated by the number 10. The active element of such a drug is felodipine in an amount of 10 mg. Excipients are lactose monohydrate, hypromellose, microcrystalline cellulose, red iron oxide, povidone, titanium dioxide, propyl gallate, yellow iron oxide, magnesium stearate, propylene glycol, silicon anhydrous colloid, talc. In the sale of this drug comes in blisters of 10 tablets. Blisters are placed in cardboard packs.

Pharmacological properties of the medicinal product

What is a medical device "Felodip"? The instruction on the use of this medication says that it is a blocker of slow calcium channels. This preparation belongs to the group of dihydropyridine derivatives.

This medicine is able to have an antianginal and hypotensive effect. In addition, it lowers the pressure (arterial) by decreasing the OPSS.

What other properties does the "Felodip" medication have? Instructions for use of the drug include information that it has anti-ischemic dose-dependent effects. The drug reduces the size of the myocardium, and also protects the human body from complications of reperfusion.

This agent has practically no negative inotropic effect. It has minimal effect on the conductive system.

Pharmacokinetics of the drug

How long does the preparation "Felodip" get absorbed? Instructions for use, reviews of this tool say that after taking the tablets inside the active substance of the drug is almost completely absorbed from the digestive tract and acts immediately. Due to its dosage form, the delayed release of the active ingredient ensures its uniform concentration in the blood (during the day), and also leads to an increase in the absorption phase.

We can not say that the bioavailability of this drug is not dependent on therapeutic dosages and is about 15%.

The binding with plasma, or rather its proteins, is approximately 99%. The drug is excreted along with breast milk and penetrates through the BBB, as well as the placental barrier. With a long use of cumulation of the active substance does not occur.

Where is the drug "Felodip" metabolized? The active component of this agent is metabolized in the liver. In this case, inactive metabolites are formed.

The half-life of the drug is about 25 hours. The drug is produced in the form of metabolites (approximately 70%) together with urine and feces (30%).

Indication of the medicinal product

In what cases is the patient assigned a medication "Felodip" (5 mg)? The instruction of this medicine contains the following list of indications for use:

• Arterial hypertension;
• Angina pectoris;
• arrhythmia;
• cardiac ischemia;
• Circulatory disorders;
• Raynaud's syndrome.

Contraindications

In what cases is it strictly forbidden to take the drug "Felodip"? The doctors' comments, as well as the accompanying instruction, state that this medication can not be used under the following conditions:

• Acute myocardial infarction, and also within a month after the infarction;
• Unstable angina;
• Cardiogenic shock;
• Heart failure, especially in the stage of decompensation;
• Aortic stenosis (clinically significant);
• Pregnancy;
• Arterial hypotension (severe);
• In childhood and adolescence (up to 18 years);
• During lactation;
• Increased sensitivity of the patient to a drug or other dihydropyridine derivatives.

It should also be mentioned that this remedy is prescribed with special care to patients with hepatic as well as renal insufficiency.

Medical device "Felodip": instructions for use

Analogs of this tool will be presented below. Now I want to tell you about how this drug should be properly taken.

With arterial hypertension, dosage for adults and elderly people is set individually. As a rule, the initial volume of the drug is 5 mg once a day. During the selection of a suitable dosage, patients are advised to use 2.5 mg tablets. If you are in urgent need, you can increase the medication dose. The average volume of the drug for maintenance treatment is 5-10 mg per day.

For elderly patients or patients with impaired liver function at the beginning of therapy, the drug is prescribed in an amount of 2.5 mg per day.

With stable angina, the medication "Felodip" is prescribed individually. At the same time, its initial dosage (for adults) is 5 mg once a day. If required, the dose can be increased to 10 mg per day. The maximum daily volume of the drug is 20 mg.

Tablets "Felodip" can be taken in combination with ACE inhibitors, beta-adrenoblockers and diuretics. However, it should be noted that the hypotensive effect is enhanced. Therefore, special care must be taken in view of the increased risk of hypotension.

In patients with severe liver disorders, the dosage of the medication should be reduced.

The presented drug should be taken only in the morning, before breakfast. In this case, the tablets in no case can not bite, crush or divide.

An overdose means

If you incorrectly use the "Felodip" tablets, the following symptoms of overdose may be noted in patients: bradycardia and arterial hypotension (expressed).

In case of occurrence of similar signs spend symptomatic therapy. With arterial hypotension (expressed), the patient is given a horizontal position, and also raise his legs. As for bradycardia, in this case, the patient is administered intramuscularly atropine at a dosage of 0.5-1 mg. If necessary, infusions of sodium chloride, glucose solution or dextran are used to increase the plasma volume.

If the above measures are ineffective, the patient is prescribed drugs with a predominant effect on alpha-adrenergic receptors.

Side effects of taking medication

Can the reception of the "Felodip" medication affect the human body in a negative way? Analogues of this drug and the drug itself often causes headache, redness of the face, dizziness, palpitations and increased fatigue. However, it should be noted that such reactions are reversible. As a rule, they appear at the very beginning of therapy, as well as with increasing dosages of the drug.

By the way, depending on the volume of medication taken, the patient may have peripheral edema. According to experts, they represent a consequence of precapillary vasodilation.

In patients with periodontitis or gum disease, a small swelling of the gums may occur while taking the medication. This process can be prevented if one observes the thorough oral hygiene.

In some cases, the reception of the medicine we are considering causes the following side effects:

• Cardiovascular system: palpitation, peripheral edema and tachycardia.
• Dermatological reactions: photosensitization, pruritus, urticaria.
• Peripheral, as well as central nervous system: paresthesia, headache and dizziness.
• Musculoskeletal system: arthralgia, myalgia.
• The digestive tract: gingival hyperplasia, nausea, increased activity of liver enzymes.
• Others: increased fatigue, hypersensitivity reactions, including angioedema.

Analogues and cost of a medicinal product

How much does the medicine that we are considering cost? This is the question that many patients are assigned to whom this medication was prescribed. It should be noted that today such a medicine can be purchased at the following prices:

• Tablets in the amount of 2.5 mg (30 pieces) - 425 Russian rubles;
• Tablets in the amount of 5 mg (30 pieces) - 556 Russian rubles;
• Tablets in the amount of 10 mg (30 pieces) - 831 Russian rubles.

What can replace the drug "Felodip"? Analogs of this drug are available in almost every pharmacy. Among them, I would like to highlight the following medicines: Plendil, Felodipine-SZ, Felodipine, and Felotenz Retard.

Positive feedback from patients about the drug

The patients' reviews of the "Felodip" preparation state that it is very effective, as well as well tolerated by patients, regardless of age and sex. In addition, this medication can even be taken by patients with diabetes mellitus, kidney disorders, bronchial asthma and other obstructive pulmonary diseases, with Raynaud's syndrome, hyperlipidemia, gout, and also after lung transplantation.

Many experts note the fact that this drug has no effect on the lipid profile and the concentration of glucose in the blood.

Negative feedback

Among the negative feedback that patients leave about this drug, one can note those related to the high cost of the drug. Although pharmacists claim that its price is fully consistent with efficiency and quality.