Eye drops Tobrex

Eye drops Tobrex are a strong antibiotic of a wide range of effects. The drug is part of the group of aminoglycosides.

Eye drops Tobrex have antibacterial action due to the suppression of the polypeptide complex and synthesis in microbial ribosomes.

The medication is used in ophthalmology for the treatment of external infections of the eyes and their appendages.

The active substance of the drug is Tobramycin.

Eye drops Tobrex are contraindicated in hypersensitivity (not excluding other aminoglycosides), myasthenia gravis, chronic kidney deficiency, parkinsonism, dehydration, impaired function in the eighth pair of nerves of the skull, in old age and during pregnancy.

Use of the drug may cause adverse reactions. The most common lesions are the auditory and vestibular branches of the eighth pair of nerves with complete (partial) deafness on both sides, dizziness, tinnitus, vertigo, drowsiness, convulsions, impaired orientation, muscular fasciculations, cylinduria, tubular kidney disorders, increased nitrogen levels and Creatinine urea. In addition, there may be anemia, leukocytosis, nausea, thrombocytopenia, eosinophilia, diarrhea, fever, anaphylaxis, pruritus, hyponatemia, rash. Conjunctival use can provoke allergic manifestations in the form of a tumor on the eyelids, itching.

Eye drops Tobrex can enhance the nephro- and neurotoxicity of other medicines. The risk of adverse reactions increases with the combined administration of loop diuretics (ethacrynic acid, furosemide). The likelihood of neuromuscular blockade increases when using Tubokurarina, Decamethonium, Succiniccholine.

An overdose of the drug is noted in the form of violations of kidney functions, auditory and vestibular disorders, paralysis of respiratory muscles, neuromuscular blockade.

The treatment consists in providing adequate oxygenation and ventilation, hydration while monitoring the fluid balance.

Tobrex (drops for eyes) are applied conjunctivally one drop five times a day. When infections in acute forms are allowed to enter every half hour or hour.

For a long-term use of Tobrex drops are not recommended.

In the process of treatment, patients should be provided with strict medical control in view of the potential for the development of nephrotoxic and neurotoxic effects. Regular audiometric tests are recommended. It should be noted that a complete or partial loss of hearing in a number of patients may develop after the completion of the therapeutic course.

In case of increased volume in the distribution of the drug (burns, peritonitis, infection in the retroperitoneal space), optimal concentration is achieved by increasing the dose. In young patients with high cardiac output and glomerular filtration rate to enhance the effect of administration is more often. For patients with impaired renal function and elderly patients, dosage should be reduced, and intervals between instillation - increased. It is recommended to regularly determine the content of calcium, urea nitrogen, magnesium in plasma, sodium, creatinine, urine sediment, urine density (relative), protein.

Prolonged local use of medicament Tobrex can provoke superinfections, including fungal.

Breastfeeding should be stopped for breastfeeding patients throughout the therapeutic course.

When using contact lenses before the introduction of the drug, they must be removed. Set them back can be no less than fifteen minutes after instillation.