Dimethinden maleate: instructions and references

Recently, more and more new funds for allergies have appeared. From this disease people of different ages, even children, suffer. Therefore, for many, it is very important to find a safe and effective remedy. Some try to buy more modern drugs, although they are quite expensive. But no less popular are drugs containing antihistamine components of the first generation, for example dimethindene maleate. This is a synthetic substance without taste and smell, poorly soluble in water. Preparations based on it have anti-allergic, antipruritic and sedative effects.

The properties of this substance

Dimethindene maleate blocks the work of histamine receptors. Due to the fact that histamine stops producing in the body, allergic reactions stop. Very well absorbed by the tissues and quickly acts dimethindene maleate. Preparations based on it have the following properties:

• Relieve itching;
• Reduce the severity of allergic reactions;
• Reduce the permeability of capillaries;
• Soothe.

But these medicines remove only the symptoms. The causes of dimethindene maleate do not eliminate.

Characteristic of this substance

Dimethindene maleate has been used in medical practice all over the world for a long time. But not all people with allergies know about it. They are looking for more effective modern drugs. But often such patients can only help dimethindene maleate. Medicines based on this substance are absorbed quickly and completely. The maximum concentration in their blood is observed after 2 hours. But the disappearance of symptoms begins in 30 minutes. The effect of these drugs lasts up to 12 hours, so it is often not necessary to take them, just once a day. Dimethindene maleate is used for oral administration in the form of a solution, tablets or capsules and externally, in the form of a gel. Now there are only three known drugs on its basis:

• "Fenistil" in the form of drops for oral administration, capsules and gel for external use;
• "Vibrocil" is a drop and spray nasal;
• "Dimethinden" is available in capsules, solution and as a gel.

Indications for use

Inside preparations based on dimethindene maleate are used according to the doctor's prescription for therapeutic and preventive purposes. Most often they are used in such cases:

• To prevent allergic reactions to allergic patients with possible effects of provoking factors;
• With chickenpox, rubella and measles to relieve itching and swelling;
• With hay fever;
• In the treatment of hives, vasomotor and chronic rhinitis;
• At the first manifestations of food or drug allergy;
• To relieve skin itching;
• After insect bites to prevent an allergic reaction;
• In the complex treatment of patients with serum sickness, Quinck's edema and anaphylactic shock.

Dimethindene maleate (gel - one of the forms of release of drugs containing this active substance) is used for hives, dermatitis, eczema, burns, skin itching, and after insect bites. In especially severe cases, it is possible to combine the external application of the drug with the ingestion of drops.

The drug "Fenistil"

Dimethindene maleate is the main active substance of this drug. Basically, "Fenistil" is known to patients in the form of a gel. It is used for itching, insect bites, dermatitis. But no less effective is "Fenistil" in the form of capsules or drops for oral administration. And the effect of drops lasts up to 6 hours, so they are taken three times a day. Capsules contain a higher concentration of dimethindene maleate, so they retain their effect up to 12 hours. In difficult cases, the doctor can decide on the need to share drops and gel.

The preparation "Vibrocil"

This medicine is prescribed for rhinitis, hay fever, otitis. It effectively removes the mucosal edema and facilitates nasal breathing. Therefore, it can also be used to relieve swelling before or after surgery, as well as during a cold. Such properties are explained by the composition of the drug: it contains phenylephrine, dimethindene maleate and auxiliary components. "Vibrocil" is available in the form of drops in the nose, spray and nasal gel. It is often prescribed to children with colds to prevent otitis.

When you can not use these drugs

All drugs based on dimethindene maleate are relatively safe. Categorically it is contraindicated to use them only during pregnancy, lactation, preterm and weakened infants, all children under 2 months, and also with individual intolerance. Other patients are prescribed such medications frequently. However, with caution and under the supervision of a doctor, this should be done for children up to a year and patients with such diseases:

• Bronchial asthma;
• Chronic obstructive pulmonary disease;
• Angle-closure glaucoma;
• Violation of the passability of the urethra;
• Hyperplasia of the prostate.

These preparations in the form of a gel are used more widely. Only 10% of dimethindene maleate is absorbed into the blood from this form of the drug. Therefore, in small areas of the skin, the gel can be used according to indications even during pregnancy in the 2nd and 3rd trimester and with breastfeeding. It can not be applied only to the nipple area.

In such cases, drugs that do not contain dimethindene maleate should be used. Analogues of it, possessing the property of blocking histamine receptors, are also effective for allergy, but some patients are better tolerated. The most famous of them are: "Tsetril", "Alerik", "Xizal", "Lorizan", "Psilo-balm" and others.

Side effects from use

In addition to antihistamines, preparations based on dimethindene maleate have a sedative effect. Therefore, the most frequent side effects after their use are weakness, drowsiness and loss of strength. Some patients may have other unpleasant feelings:

• Dizziness, headaches;
• Muscle spasms;
• Nausea, dry mouth;
• Difficulty breathing.

If the recommended dose is exceeded, there may also be convulsions, hallucinations, a rise in temperature, a strong drop in pressure. Infants may have motor excitation and difficulty breathing.

After using the drugs in the form of a gel, there may be rashes and swelling, dryness and itching at the site of application.

Dimethindene maleate: instructions for use

It is necessary to strictly observe the dosage of taking such drugs, especially in young children. At the age of one to 12 years it is calculated individually, depending on the weight of the child. It is easiest to give drops to children: from 2 months to a year three times a day from 3 to 10 drops, up to 3 years - up to 15 drops, from 3 to 12 years - 15-25 drops. They can be given simply with a spoon (they do not have a taste or smell) or they can be added to a bottle.

Adults and children over 12 years of age are shown taking 3 to 6 mg per day. This dose is divided into 2-3 doses. For example, in the morning - 2 mg, and before bedtime - 4 mg or three times a day for 2 mg. If the drug is taken in solution, it is drunk 20-40 drops 3 times a day. Ingest preparations based on dimethindene maleate can drink no more than 25 days.

The gel for external application is applied to the affected skin areas 2-4 times a day.

Special instructions when using these drugs

The sedative effect of dimethindene maleate promotes the appearance of drowsiness after taking it. Therefore, when using drops or tablets in the morning, you can slightly reduce the dosage. But all the same it is undesirable to drive a vehicle or perform other tasks requiring increased care. In addition, there are several other features of the use of such drugs:

• They can not be combined with alcoholic beverages;
• They increase the effect of sleeping pills;
• After using the gel, skin exposure to sunlight should be avoided;
• If you take dimethindene maleate along with antidepressants, it is possible to increase intraocular pressure;
• For children under one year, the gel should not be applied to large surfaces, and drops should be used with great care.

Reviews

Preparations based on dimethindene maleate in the form of a gel quickly dried and relieve itching for allergic rashes, insect bites. Reviews of tablets and capsules are positive, especially with seasonal manifestations of allergies. Adverse reactions are not manifested more often than it is stated in the instructions. Among the minuses note the high cost of the drug.