The drug "Triftazin": instructions for use, price, analogues, reviews. Overdose, side effects and the abolition of "triftazin"

Drug "Triftazin", the instruction to which will be detailed in this article, is considered one of the most effective antipsychotics. The use of this drug is associated with many subtleties in terms of dosage and duration of therapy.

Description of the preparation, composition

According to group membership, the drug "Triftazin" refers to strong antipsychotic drugs with pronounced antiemetic effect. The main active substance is a compound from the phenothiazines group - trifluoperazine, which can affect not only the central nervous system, but also its peripheral parts, which, in fact, has an antiemetic effect.

The injection solution is a clear, colorless liquid with no specific odor and taste. Tablets "Triftazin" rounded, covered with a shell of blue, on a fracture of white or almost white color.

Form of issue, terms and conditions of storage

Drug "Triftazin", doctors' reviews about which are almost always positive, is issued in two dosage forms: as a solution for injections and in tablets. The active substance content in each ampoule with the solution is 0.2% (2 mg per 1 ml of solution). Ampoules are packed in cardboard boxes of 5, 10 or 100 pieces together with a special ampoule knife and instruction for the use of the drug.

In tablets "Triftazine" the active substance is contained in an amount of 0.005% (0.5 mg). They are packed in blisters of 10 pieces, which, in turn, are placed in cardboard boxes of 4, 5 or 10 pieces in each. Also this dosage form is produced in packages of dark glass or opaque white plastic containing 50 or 100 tablets.

Shelf life of all medicinal forms is 3 years. Keep the tablets and Triftazin solution recommended for use in a cool place with good ventilation. It is inadmissible to get direct sunlight and liquids on the medicine packs. After the expiry date is not recommended to take the drug.

Pharmacological properties of the drug Triftazin

Let's consider the main properties of the drug Triftazin. Instructions for use (official) contains detailed information on the mechanism of action of the active substance of the drug on the receptors of the brain and vagus nerve in the gastrointestinal tract. So, it says that trifluoperazine blocks the PMD receptors in the brain and the D2 receptors in the cerebellum. In addition , the neuroleptic is able to have an alpha-adrenoblocking effect, that is, it actively influences the level of arterial pressure, reducing it.

Trifluoperazine has not been thoroughly studied in terms of pharmacokinetics, but it is for certain known that it actively binds to plasma proteins (at least 80%). The mechanism of disintegration of the compound into metabolites has also been studied little. Removal of the drug from the body occurs mainly through the kidneys, a small part of the active substance and its metabolites is excreted through the intestine (with bile).

Indications for use

Since the action of the drug "Triftazin" instruction for use classifies as antipsychotic, a variety of mental disorders are included in the range of diseases in which it is advisable to use it. Among them - schizophrenia, psychomotor disorders, anxiety and phobia (uncontrollable obsessive fears). In addition, the drug is used to treat vomiting, not caused by diseases of the digestive system.

How safe is the drug we are considering and whether all of the patient categories can use Triftazine? Instructions for use, expert reviews of it allow us to conclude that it is necessary to take the drug only after a comprehensive examination, as it has a number of serious contraindications and side effects. Despite the fact that the medicine is dispensed without a prescription, it is not necessary to decide on its own.

Contraindications

Tablets and solution for injection "Triftazin" have contraindications for use, which imply the impossibility of their use. Among them are the depression of the central nervous system and coma. In addition, the drug "Trifthazin" instruction for use does not recommend taking with heart, liver and kidney, hematopoiesis. The stage of the disease and the severity of its course do not play a significant role. The fact is that there are a number of consequences of taking tablets and a solution of Triftazine. The side effects that will be considered later are themselves very serious, and in the presence of concomitant pathologies, they can provoke even more complex consequences for the patient's body.

It is also not recommended to use this remedy if there is an allergic reaction to any component of the drug in the anamnesis.

Use of "Triftazine" during pregnancy

The active substance of the drug Triftazin (the doctors' reviews contain a lot of supporting information on this matter) has a negative effect on the developing fetus. That is why it is absolutely not recommended to take the drug during pregnancy. The fact is that the active substance trifluoperazine in the fetal tissues is found in concentrations significantly exceeding therapeutic doses. It is it that provokes a weak set of fetal mass, and also increases the risk of developing various vices in its development.

The drug Triftazin (analogues for the active substance is also worth taking into account) is not recommended for lactating women, since the components of the drug are found in breast milk. Even if the mother does not observe any side effects, the baby in the future may face such problems as tardive dyskinesia and retardation.

Side effects

As mentioned earlier, the drug Triftazin can cause a number of undesirable reactions from almost all organs and systems. First of all, the active substance affects the nervous system of the patient, which means that the lion's share of side effects occurs precisely in it. First of all, they include such phenomena as tremor, neck and tongue cramps, which can make speech incoherent (extrapyramidal reactions). Also often there are symptoms of late dyskinesia, insomnia, akathisia and vegetative disorders.

The most common adverse reactions from the central nervous system caused by the use of the drug "Triftazin", reviews called drowsiness, dizziness and loss of visual clarity. Usually, such symptoms appear in the first day after the beginning of treatment with the medicine.

What else can cause the injection of solution for injections or tablets "Triftazin"? Side effects, according to patients and doctors, often affect the digestive system. It manifests itself in the form of dry mouth and anorexia. Also, there are often problems with the normal functioning of the liver. In addition, there may be allergic skin rashes, amenorrhea, agranulocytosis.

special instructions

The above undesirable effects can be mitigated by symptomatic therapy or dose adjustment. The abolition of "triftazin" is required only if there are serious abnormalities in the functioning of the patient's systems. So, let's consider the basic techniques and methods of getting rid of or alleviating unwanted reactions of the body to the drug.

When there is tremor or seizures, in most cases, specialists decide to reduce the patient's dose of the drug or temporary discontinuation of its reception. In especially severe cases, treatment with antiparkinsonian drugs, barbiturates or caffeine preparations (intravenous administration) may be required .

When there are pronounced symptoms of insomnia or motor disinhibition, agitation is not recommended to increase the starting dose of the drug. As a rule, adaptation of the organism to a new medicine takes place within a few days, and unwanted symptoms gradually disappear. Otherwise, you may need to take benzodiazepine or propanolol medication.

Such a condition as tardive dyskinesia, mentioned in the side effects when taking Trifthazine, which will be discussed later, most often develops as a result of long-term medication intake or soon after its withdrawal. Specialists note that dyskinesia (late) is most often diagnosed in elderly patients.

Some of the side effects caused by taking medication are incompatible with actions such as motor vehicle management and complex mechanisms. At the time of treatment, "Triftazinom" is better to abstain from them.

Recommendations for dosage and methods of taking the drug

Dosage of the drug is determined by a specialist based on the individual characteristics of the patient: his condition and the presence of concomitant diseases. At the beginning of the course of therapy, the minimum doses of Triftazin are usually prescribed. Tablets instructions prescribe taking 1-5 mg 2 times a day (adult patients). Over the next three weeks, the dosage is gradually increased and adjusted to 45-60 mg per day. This amount must also be divided into three methods.

For the treatment of children, it is customary to use smaller doses of the drug. At the beginning of therapy take no more than 3 mg per day (in 3 doses). If necessary and the absence of pronounced symptoms of adverse reactions, the dosage is increased to 5-6 mg per day.

Solution for injection "Triftazin" must be administered intramuscularly with an interval of no more than 6 hours. The daily dose of the drug for adults at the same time is a maximum of 10 mg. Children are given a dosage of 1 mg per day, divided into 2 injections, with an interval of at least 12 hours.

We draw the attention of the reader to the fact that treatment with this drug, regardless of the dosage form used, should be performed under the supervision of the attending physician. It is he who decides to change the dosage of the drug Triftazin. Overdosing with proper use of the drug is almost impossible. Unauthorized administration of the drug or a change in the recommended doses to a larger side may lead to unpredictable consequences.

Drug Interactions

All medicines have the property of interacting with each other. Tablets and injection for injection "Triftazin" in this regard are no exception. Usually, experts take into account a variety of factors affecting the effectiveness of the appointment of this drug. So, medicines containing ethanol (syrups, tinctures and the like) can enhance the CNS depressing properties of Triftazin, and also negatively affect respiration processes.

Together with drugs that reduce blood pressure, tablets or solution of "trifthazin" should be used very carefully, since it is possible to develop acute orthostatic hypotension.

Antatsidnye and protivoparkinsonicheskie means contribute to a less absorption of the active substance tablets "Triftazin" from the digestive tract, and, therefore, reduce the effectiveness of the drug.

Negative effect is seen when the drug is combined with lithium salts. According to the data obtained, this combination is fraught with the development of pronounced extrapyramidal symptoms and an increase in the neurotoxic effect of trifluoperazine.

Reviews about the medicine "Triftazin"

Before starting the drug, many people try to find feedback about it. Drug "Triftazin", judging by the comments of specialists, is considered one of the most effective. At the same time, they note that uncontrolled intake of the drug can negatively affect not only the physical, but also the mental state of a person.

For those patients who are shown taking this medication, in many cases it is the only way to lead a normal life. Of course, it does not do without the development of side effects. But, according to statistics, all unpleasant symptoms disappear within a maximum of two weeks after the initiation of therapy.

The patient's opinions about the drug Triftazin are ambiguous. One he really helped, and others so severely suffered side effects that they had to abandon this remedy. Very often consumers indicate the appearance of fatigue, apathy and general weakness. In isolated cases, patients fell into a state when they did not want to commit even elementary movements.

Women, unlike men, often mention weight gain during treatment with Triftazin. Experts also argue that there is no direct relationship between therapy with this drug and weight gain. According to their assumption, this is associated with a decrease in motor activity of patients against the background of maintaining the old diet.

Regarding the effect of the drug, both doctors and patients recognized that this remedy really alleviates or eliminates the symptoms of the underlying disease at all.

Analogues and cost of the drug

So, we have considered the main questions on the use of the drug Triftazin. Do they have equivalent substitutes, or so-called analogues? Of course, there are a lot of such drugs. Neuroleptics are produced today by almost all pharmaceutical companies, and most of the drugs from this group are synonymous with Triftazin (that is, they correspond to it in composition). These include preparations "Vespesin", "Trifluoperazine hydrochloride", "Trifluorazine hydrochloride", "Fluezin", "Equazine", "Stelazin", "Cyclodol" and many others.

The cost of these drugs is not always the same. Foreign analogues are more often more expensive, compared to the drug Triftazin, which costs an average of 50-70 rubles per package (50 tablets). If we consider that therapy with the use of this remedy is long, we can regard its cost as one of the main advantages over imported analogues.