SIGNITEF (eye drops): instructions for use, description, composition and reviews

In what dosage is prescribed the medicine "Signtsef" (eye drops)? Instructions for use, price and indications of the drug will be presented in this article. Also in it you will find information about what the patients say about this tool, whether it has analogs, side effects and contraindications.

Composition, description and packaging

The drug "Signtsef" (eye drops), the instruction for which is enclosed in a cardboard package, contains an active substance such as levofloxacin hemihydrate. As additional components use sodium chloride, hydrochloric acid, benzalkonium chloride, hypromellose, sodium hydroxide and water.

For sale, the medicine in question is in the form of a clear liquid of light yellow color, which comes in the droppers made of plastic.

Pharmacodynamics of the preparation

How does the medicine "Signtsef" (eye drops) work? The instruction for use states that the said preparation is an antimicrobial and antibacterial agent.

Its active substance inhibits topoisomerase IV and DNA gyrase, as well as inhibits the synthesis of DNA, prevents cross-linking and supercoiling of DNA. It should also be said that this medication is capable of provoking morphological changes in the cytoplasm, membranes and cell walls of bacteria.

Eye drops have a detrimental effect on both gram-positive and gram-negative aerobes. In addition, they are active against Chlamydia trachomatis.

After using the drug, its active component accumulates in the lacrimal film. At the same time, the concentration of the drug substance in the tear fluid quickly reaches high values and lasts for six hours.

Indications

At what diseases should I use the medicine "SIGNITSEF" (drops)? Instructions for use, reviews of ophthalmologists say that the drug in question is often used when:

• Treatment of anterior segment infections and an adnexa, which was triggered by bacteria sensitive to levofloxacin;
• The need for prophylactic measures after operations before the eyes;
• Local therapy for infectious eye diseases that were provoked by bacteria susceptible to levofloxacin.

Contraindications to the use of eye drops

What kind of contraindications should you know before using SIGNITEF (eyedrops)? Instruction for use states that this medication is prohibited when:

• Defeats of tendons;
• Hypersensitivity to the elements of the drug;
• Previously conducted treatment with quinolones;
• Breastfeeding;
• Epilepsy;
• Pregnancy.

Also, do not use eye drops for infusions. With caution this drug is prescribed in childhood.

SIGNITEF (Eye Drops): Instruction

The prices and analogues of the medicament in question will be presented at the end of the article.

The instruction informs that this drug should be started to be applied within the first two days after the appearance of signs of the disease. The drug is instilled in the infected eyes in an amount of 1-2 drops at intervals of 120 minutes.

The maximum frequency of this medication is 8 times a day. In 2 days after the beginning of treatment the drug is started to be applied in the same dose, but already 4 times a day.

The duration of therapy directly depends on the characteristics and severity of the disease. Usually treatment lasts for 5 days.

Before applying drops to the patient, the head should be turned back, and then the lower eyelid should be pulled back. It should be dripped, and then close your eyes for a few minutes.

To prevent the drug from getting into the tear duct, the inner edge of the optic organ should be pressed with a finger and held in this condition for 1-2 minutes. At the same time it is forbidden to blink.

As for the remains of eye drops, they are removed with a clean cloth, but without contact with the eyes.

Adverse Reactions

Side effects on the background of the use of the drug in question are extremely rare. As a rule, such reactions are characterized by a moderate or weak degree of severity and after some time pass independently.

So what are the undesirable effects of SIGNITSEF? Instructions for use (the description of the drops was presented above) indicates that the agent may provoke the appearance of the following ophthalmic disorders:

• Burning in the eyes, matting eyelids, deterioration of visual acuity;
• Pain in the eyes, papillary reaction of the conjunctiva, edema of the eyelids;
• Conjunctival follicles, pruritus, erythema eyelid, conjunctival infection;
• Chemosis, photophobia, dry eyes.

Sometimes, from the side of the immune system, anaphylactic and allergic reactions are observed in patients.

As for the central nervous system, dizziness, drowsiness, headaches, paresthesia, confusion, fear, weakness, movement disorders, anxiety, insomnia, depression, hallucinations and convulsions can occur on her part.

Also, rhinitis, thoracic and mediastinal disorders may occur.

Cases of overdose

With the occasional administration of eye drops, toxic effects on the body are excluded. This is due to the fact that the amount of levofloxacin in the preparation is too low.

If a local overdose has occurred, the patient may experience increased adverse reactions. In this case, the drug should be discontinued and the eyes thoroughly rinsed with warm water.

Drug Interactions

The drug "SIGNITSEF" reduces the effectiveness of agents that inhibit bowel motility, as well as aluminum-containing and magnesium-containing antacid drugs, sucralfate and iron salts. The interval between the use of these medicines should be two hours.

The droplets in question increase the half-life of "Cyclosporine."

Removal of levofloxacin is significantly slowed by the simultaneous use of drugs that inhibit tubular secretion, and "Cimetidine."

Special Recommendations

Eye drops "Signiteft" is not recommended for use during the wearing of soft contact lenses due to the presence of the preservative benzalkonium chloride in the preparation.

To avoid getting dirt in the bottle, do not allow the dropper contact with mucous eyes.

Price, similar preparations

The average cost of the funds in question is about 220 rubles.

As for similar drugs, they include the following: Oftakvix, Glevo, Lebel, Levobaks, Levogrin, Levolety, Levotor, Levofast, Loksof, Novoks , "Remedy", "Floksium."

Reviews of eye drops

Eye drops "SIGNITSEF" (instruction, price, reviews described in this article) are a very popular drug. Reviews about them are mostly positive.

Patients talk about the high efficiency of the solution. He treats infectious diseases of the eye quite quickly, and is also great for prevention.

Among the negative responses are those in which patients complain about the high cost of medication and the inability to use it during breastfeeding and when carrying a child.