Preparation "Algezir Ultra": instructions for use, description, composition and reviews

Recently, doctors often appoint patients "Algesir Ultra". The instruction for this tool is quite informative and describes the features of its use for various categories of patients, but it does not provide much information about how this agent works on the body.

Pharmacology

In the composition of the drug - NSAID, which is a derivative of naphthylpropionic acid. In the process of taking this drug is anti-inflammatory, antipyretic, as well as analgesic effect, which is often evidenced by reviews about "Algesir Ultra." The instruction to the tool also points to these nuances.

The mechanism of action of the drug is directly related to the inhibition of the specialized enzyme COX, which makes it possible to oppress the synthesis of prostaglandids from arachidonic acid as effectively as possible. Also, this agent provides suppression of platelet aggregation.

Special attention should be paid to the fact that during the administration of the drug pain syndrome decreases, including joint pain both in motion and at rest. In the process of admission swelling of the joints decreases, morning stiffness, the volume of movements increases, which is noted by almost everyone who left feedback about the Algesir Ultra. The instruction also contains such information, while it also notes that the anti-inflammatory effect can be achieved by the end of the first week of active treatment.

Pharmacokinetics

Subsequently, taking this medication internally naproxen begins to absorb quickly enough from the digestive tract. The C _max in the plasma begins to be observed already for 1-4 hours after administration. It should be noted that the simultaneous use of this drug with food can somewhat slow down the rate of absorption, but it does not reduce the overall absorption. Naproxen differs fairly good absorption in the case of rectal administration, but in this case there is a much slower absorption, when compared with ingestion.

In therapeutic concentrations, this element binds to plasma proteins by almost 100%. The concentration of naproxen in plasma increases proportionally in the use of doses up to 500 mg, while at higher doses there is an increase in clearance, which is due to the full saturation of plasma proteins.

Naproxen diffuses into the synovial fluid.

T _1/2 is approximately 13 hours. About 95% of the total amount of this dose is ultimately excreted in the unchanged state of urine, 6-O-desmethylnaproxen and its various conjugates. All the rest in the near future after the reception is excreted with feces.

Dosage

It is worth noting that it is recommended that the individual dosage is set in accordance with the severity of the disease course in the patient. To the preparation "Algesir Ultra" the instruction says that adults are advised to take it at doses of 0.5-1 g per day in two divided doses, while the daily dose for normal maintenance treatment should be about 500 mg.

The maximum possible daily dose is 1.75 g.

Dosage for children

If treatment is carried out in patients aged 1 to 5 years, then they should use 2.5-5 mg per kg per day for 1-3 doses daily, with the maximum possible course of treatment in this case may be 14 Days. In the treatment of juvenile arthritis in children older than 5 years, the daily dose is fixed and is 10 mg per kg.

The medicinal interaction of the "Algezir Ultra"

Instruction for use says that if it is used simultaneously with antacids, which include aluminum and magnesium, as well as sodium bicarbonate, then in this case it negatively affects the absorption of naproxen, which is quite important in the treatment process.

If the agent is used together with indirect anticoagulants, then there may be minor enhancements in the effect of these drugs, which was noted in the process of carrying out specialized clinical studies.

Also in the process of conducting studies, the effect of simultaneous use of the drug with amoxicillin was studied, which resulted in the development of a nephrotic syndrome in certain situations . If "Algesir Ultra" was used with acetylsalicylic acid, in some cases the total concentration of naproxen in the blood plasma decreased.

Additional features of interaction

Among other things, it is worth noting a few more situations, which are indicated in the instruction for the preparation "Algesir Ultra" (tablets):

• With simultaneous use, the possibility of certain changes in the pharmacokinetic parameters of diazepam is provided;
• If this agent is simultaneously used with caffeine, the effect of naproxen may be enhanced;
• When combined with lithium carbonate , it is possible to increase the concentration of lithium in the blood plasma;
• Combination with methotrexate increases the degree of toxicity of this substance;
• When "Algezir Ultra" is used simultaneously with probenecid, the total concentration of naproxen in the blood plasma is reduced;
• Simultaneous application with salicylamide makes it possible to enhance the action of this substance.

There is information indicating that if the drug is used concomitantly with morphine, ultimately it can lead to the development of myoclonus. Also, with simultaneous use with prednisolone, there is a significant increase in the degree of concentration of this substance in the blood plasma. In addition, there is also a simultaneous use with furosemide, which provides for a decrease in the diuretic effect of this substance. This is noted about such a tool as the drug "Algesir Ultra", reviews. The instruction also indicates this feature of the medication.

Lactation and pregnancy

It is recommended to use this medication with extreme caution in pregnant or lactating women, and in particular this applies to those who are currently in the first or third trimester. The thing here is that after taking this drug naproxen begins to penetrate the placental barrier, and subsequently is released in small quantities with breast milk.

Side effects

It should be noted several side effects, which indicates the preparation "Algesir Ultra" instructions for use. Descriptions in this case are provided for different groups of bodies:

• Digestive system. In the course of admission, there may be vomiting, nausea, a feeling of discomfort in the epigastric region. In rare cases, there are erosive and ulcerative lesions of the digestive tract, as well as various violations of liver function and bleeding.
• Central nervous system. When using the drug in some patients, drowsiness, headache, as well as slowing the speed of psychomotor reactions. In very rare cases, using this tool, there are various hearing impairments, as evidenced by the instruction "Algesir Ultra" instructions for use. The abstract does not describe in detail this feature of use.
• The hematopoiesis system. Extremely rare use of the drug leads to the occurrence of granulocytopenia and thrombocytopenia, as well as hemolytic or aplastic anemia.
• Respiratory system. In rare cases, eosinophilic pneumonia may develop .
• Urinary system. In rare cases, various renal impairment may occur.
• Allergic reactions. In a certain group of patients, urticaria, skin rash and Quincke's edema were observed during the study, which is a fairly common allergic reaction to the various components that make up the drug, as mentioned in the "Algesir Ultra" instructions for use. Treatment in this case may not be suspended.

Among other things, it deserves special attention that in the case of rectal use, there is a risk of mucoid secretions with small blood impurities or the appearance of painful defecation.

When is it used?

In the last few years, modern doctors have often started prescribing this medication to their patients during the treatment of a variety of diseases, including those that describe the instructions for use of the Algesir Ultra. The price of this drug is affordable to almost everyone, and therefore it is prescribed often instead of the majority of the most similar means.

In particular, it is worth noting several major ailments, in the treatment of which it is used most actively:

• osteoarthritis;
• rheumatoid arthritis;
• Ankylosing spondylitis;
• Exacerbation of gout;
• Articular syndrome;
• neuralgia;
• Myalgia;
• Pain in the spine;
• Traumatic inflammation of soft tissues or the musculoskeletal system.

Among other things, "Algesir Ultra" is often found as an auxiliary in the treatment of various infectious and inflammatory diseases of the ENT organs, primary dysmenorrhea, adnexitis, as well as dental and headaches.

Contraindications

There are several cases in which this tool is not recommended to use, and this indicates the "Algesir Ultra" preparation instruction on the application (description). Physicians' reviews also often indicate that this drug is highly not recommended for use in the following situations:

• "Aspirin triad";
• All kinds of erosive and ulcerative lesions in the gastrointestinal tract;
• Pronounced disorders in the functions of the kidneys;
• Violation of the hematopoiesis system;
• Pronounced disorders in the functions of the liver;
• Too high sensitivity to naproxen and other substances that are part of this drug.

Among other things, the use of this remedy is not recommended for children under the age of one year, as evidenced by the instruction "Algesir Ultra" instruction. The price of this product is 85-90 rubles. For 10 tablets.

special instructions

Extremely cautious this tool should be used in the treatment of various diseases of the kidney and liver, gastrointestinal tract in history, as well as heart failure, hypertension or the presence of dyspeptic symptoms. In particular, it should be mandatory to consult with a doctor as to whether the drug can subsequently be used for significant surgical interventions.

In the treatment should always maintain systematic control over the work of the kidneys and liver, as well as the picture of peripheral blood. If it is necessary to determine the degree of concentration of 17-ketosteroids, the intake of naproxen will necessarily have to be canceled 48 hours before the proposed study date.

Particular attention should be paid to the fact that taking this medicine affects the ability to drive cars and manage various mechanisms. In this regard, it is best to abstain from any potentially dangerous activities directly related to the need for concentration of attention and increased speed of psychomotor reactions, while "Algezir Ultra" is being used. Instructions for use on the drug separately underlines this point.