Lincomycin hydrochloride.

Many do not even suspect what a lot of antibacterial substances are known to date. However, this diversity is associated not only with the development of medicine and pharmacology, but also with the increasing need of mankind for these drugs.

A major disadvantage of any antibiotic is that resistance develops to them. Some funds can be taken in several courses in a row, and their effectiveness does not decrease, but there are also those that cause insensitivity of flora from the first days of admission.

Lincomycin hydrochloride is an antibacterial drug belonging to the group of lincosamides. It is produced by a group of actinomycetes and some other microorganisms with similar properties.

When a person enters the human body, a drug substance passes through a series of conversion steps. First, the shell of the tablet or capsule in the stomach is destroyed, and then in the small intestine the drug is split into small particles that are capable of entering the blood. With the blood flow, the medicine enters the inflammatory focus and binds to the large pyroxisome of the ribosomes. In other words, lincomycin hydrochloride disrupts all reactions of the vital activity of bacteria, which leads to their death. The half-life of the drug from the body is about 5 hours, respectively, after this time it is necessary to introduce a second dose of the drug.

After a few hours after its administration, the maximum therapeutic concentration of lincomycin is observed in the blood. It is best to take lincomycin hydrochloride one hour before a meal or through the same amount after, since Taking together with food reduces the absorption of the drug by 50%.

Metabolic changes in the drug pass mainly in the liver, and it is excreted by the kidneys, respectively, a violation of the work of any of these organs can lead to a delay in the decomposition products of the antibiotic in the body - and the development of a toxic reaction.

It should be noted that this antibiotic possesses simultaneously bi-directional action: bactericidal and bacteriostatic. One of them may dominate the other or not at all - it all depends on the sensitivity of the microorganisms and the dosage of the drug. Of course, of no less importance is the duration of the drug, and its compatibility with other drugs.

Lincomycin hydrochloride has the maximum therapeutic effect against Gram-positive non-spore-forming anaerobic bacteria, but its positive effect on some spore anaerobes has also been noted.

Indication of the drug:

- diseases of the upper and lower respiratory tract of an infectious nature;

-pathology of ENT organs (otitis, sinusitis, pharyngitis and laryngitis);

- infectious and pustular lesions of the skin, soft tissues and joints;

- dysentery and scarlet fever.

Lincomycin hydrochloride is prescribed to adults at 1.5 grams per day, which are divided into 3 divided doses (2 capsules 3 times a day). An 8-hour interval between taking capsules should be observed. Uncontrolled use of antibiotics can cause a number of side effects. With more severe and long-lasting infections, you can increase the daily dosage of the drug to 2 grams.

Children under the age of 14 years, lincomycin (capsules of 500 mg) are prescribed depending on the weight, more precisely 30 mg per kilogram in 4 divided doses, if necessary, you can increase the dosage to 60 mg per kilogram of weight.

The entire course of therapy ranges from 10 days to 3 weeks, depending on the severity of the disease and the patient's immune status .

Some patients may experience some pathological reactions after taking the drug:

- vomiting and diarrhea;

- rashes on the skin and mucous membranes;

- jaundice;

- Anemia;

- superinfection.

It is necessary to take antibacterial drugs only according to the doctor's prescription in the indicated dosage and with the observance of the time interval between receptions. If any unusual symptoms or symptoms occur after taking the drug, you should immediately consult a doctor and do not use it before counseling.