"Komfoderm": instructions for use, description, composition, analogues and reviews

What do you know about such a drug as "Komfoderm"? Instructions for use, price, reviews, analogues and general characteristics of this medication are known to a few. Therefore, in this article, we decided to provide all the information about this medication.

Form, composition and description

The drug "Komfoderm", the instruction for use of which is described below, is produced in the form of a white cream with a specific odor (can be without it, and also have a cream shade).

The active components of this topical preparation are methylprednisolone aceponate and urea. Also, the composition of the medicinal ointment includes auxiliary ingredients, which are presented in the form of liquid paraffin, propylene glycol, polysorbate-80, carbomer interpolymer (type A), trometamol, methyl hydroxybenzoate and purified water.

Healing properties

What is the local preparation "Comfoderm" (cream)? Instruction for use reports that this glucocorticosteroid and keratolytic agent at the same time. Its effect is due to the peculiarities of the components that make up its composition. Let's consider their properties in more detail.

Methylprednisolone aceponate is a synthetic, non-halogenated steroid. With external use, it is able to suppress allergic and inflammatory skin reactions, as well as reactions that are associated with increased proliferation. This effect leads to a significant reduction in the objective signs of the inflammatory process (erythema, edema, mocclusion) and subjective sensations (itching, irritation, pain, etc.).

One can not but say that when using this substance at the recommended dose, its systemic effect on the human body is minimal.

After a long and repeated use of methylprednisolone aceponate on large surfaces of the skin (40-60%), as well as when applied under the occlusive dressing, the patients do not suffer from disturbances in the adrenal glands, including the level of cortisol.

The substance in question is capable of binding to glucocorticoid intracellular receptors, causing a number of biological effects. In particular, this chemical process leads to the induction of the synthesis of macrocortin. The latter inhibits the release of arachidonic acid and the formation of inflammation mediators such as leukotrienes and prostaglandins.

What role does urea play in Comfoderm? Instructions for use say that this component has moisturizing and keratolytic effects. It binds the water, which causes the softening of the stratum corneum.

In addition to keratolytic action, urea also exhibits proteolytic activity.

Kinetics

Is the cream "Komfoderm" absorbed? Instructions for use asserts that after the application of this means of methylprednisolone, aceponate is almost immediately hydrolyzed in the dermis and epidermis.

The most active and the main metabolite of this substance is 6-methyl-prednisolone-17-propionate.

The degree of cutaneous absorption of the drug in question depends on the state of the human integument and the way it is used (without or with an occlusive dressing).

Percutaneous absorption of medicament in people with psoriasis and atopic dermatitis is about 2.5%, which is slightly higher than in healthy volunteers (approximately 0.6-1.5%).

Upon ingestion of 6alpha-methylprednisolone-17-propionate into the systemic bloodstream, it is quickly conjugated with glucuronic acid and then inactivated.

Metabolites of the drug under consideration are eliminated mainly through the kidneys, after 16 hours. Active components of this drug do not accumulate in the body. Due to the low absorption of urea with topical application of the cream, the probability of its systemic effects is negligible.

Indications

What is the "Comfoderm" (ointment) appointed from? Instruction for use contains the following list of indications:

• Eczema microbial;
• Dermatitis, allergic (contact);
• Neurodermatitis, atopic dermatitis;
• Eczema is true;
• Dermatitis simple contact;
• Eczema dyshidrotic.

In other words, this drug is prescribed for inflammatory skin diseases accompanied by a violation of keratinization, as well as those exhibiting high sensitivity to treatment with topical glucocorticosteroids.

Contraindications

The drug "Komfoderm", the instruction for its use is obligatory for the reading of all patients, it is forbidden to use at:

• Hypersensitivity to the elements of the cream;
• Tuberculosis or syphilitic processes in the field of drug application;
• Viral diseases (including chicken pox, shingles surrounding it);
• Rosacea, perioral dermatitis in the area of ointment application;
• Any manifestations of vaccination;
• At a minor age.

Medication "Komfoderm" (ointment): instructions for use

The price of the funds in question is about 480-530 rubles. The drug is applied to the affected skin areas in a small layer, once a day.

The duration of continuous and daily treatment with this cream should not exceed 12 weeks. It should be noted that facial skin lesions should be treated for 5 days.

Side effects

What side reactions can the drug "Komfoderm M2" cause? Instruction for use reports that such effects occur very rarely. As a rule, they are manifested in the form of the following local reactions: itching, erythema, burning, the formation of vesicle rash.

In the event that the medication has been used for more than four weeks or in large areas of the skin, the patient may develop atrophy of the skin or telangiectasia, as well as acneform changes, striae and systemic effects that result from the absorption of the corticosteroid.

Also sometimes the drug under consideration causes hypertrichosis, folliculitis, skin depigmentation, perioral dermatitis and allergic reactions.

Comments of consumers and analogues of "Komfoderma"

The analogues of this drug include only the cream "Advantan".

What do patients say about the "Komfoderm" ointment? According to their reviews, this medication is a very effective local remedy. Its use allows you to get rid of various skin diseases, including eczema, neurodermatitis and dermatitis. In some cases this drug is used even with psoriasis.

The shortcomings of the ointment "Komfoderm" include its high cost, as well as the inability to use in childhood.