'Ketorol' in ampoules

"Ketorol" in ampoules belongs to the group of non-steroidal anti-inflammatory drugs. The medication also has an analgesic effect, the effect of which is compared with morphine, and a moderate antipyretic effect.

After the administration of the drug "Ketorol" in ampoules, the analgesic effect begins in thirty minutes. An hour later, the maximum effect is achieved.

After the injection, the drug is completely and rapidly absorbed into the systemic bloodstream from the injection site.

The drug "Ketorol" in ampoules is contraindicated during the prenatal period and during lactation. Penetration of the drug into breast milk.

More than half of the dose is metabolized in the liver with the formation of metabolites pharmacologically inactive. The main metabolites are p-hydroxycetorolac and glucuronides.

91% is excreted by the kidneys, 6% by the intestine. Excretion of glucuronides is carried out with urine.

"Ketorol" in ampoules is prescribed for pain syndromes of strong and medium severity of different genesis (including, with pain in postoperative periods and with cancer).

Ketorol (injections). Instructions.

Intramuscular administration is prescribed in minimally effective, selected with allowance for the intensity of pain syndromes and the response of the patient to doses. If necessary, "Ketorol" (injections) is prescribed in combination with reduced doses of opioid analgesics.

For patients under 65, the drug is administered at a dosage of 10 to 30 mg every four to six hours, depending on the intensity of the pain or 10 to 30 mg at a time.

For patients over 65 years of age, the intramuscular dose of the drug is 10 to 15 mg at a time or 10 to 15 mg every four to six hours, taking into account the pain intensity.

The maximum dosage during the day for patients up to 65 years is 90 mg, for patients after 65 years of age or with disorders of kidney function - 60 mg. Therapeutic course is appointed no more than five days.

The use of "ketorol" may cause adverse reactions.

From the side of the gastrointestinal side effects are expressed in diarrhea, constipation, a feeling of fullness in the stomach. In rare cases, lesions of the gastrointestinal tract are erosive-ulcerative. Adverse reactions include nausea, a burning sensation in the epigastric region, vomiting, spasms, acute pancreatitis, hepatitis, and others.

Rarely there are violations of the urinary system, expressed in acute renal failure, back pain, frequent urination, nephritis, impairment (decrease or increase) in the volume of urine, edema.

In a number of cases, bronchospasm, rhinitis, and laryngeal edema are observed.

The drug has an effect on the functions of the central nervous system. In many cases, taking the drug causes dizziness, drowsiness, headaches. Rarely does aseptic meningitis, depression, hallucinations, hearing loss, psychosis, visual disturbances occur.

In some cases, patients have increased blood pressure, in rare cases - pulmonary edema and fainting. In rare cases, there is leukopenia, eosinophilia, anemia.

When using the drug in postoperative periods, in some cases, there is an increase in bleeding from wounds, nose, or rectal bleeding.

In rare cases, taking the drug causes a skin rash, exofoliative dermatitis, hives and the like.

As local reactions, there may be pain or burning in the area of administration.

The drug is contraindicated in persons with hypersensitivity to NSAIDs suffering from bronchospasm, peptic ulcers, angioedema. No medication is prescribed in the phases of exacerbation of erosive and ulcerative gastrointestinal lesions, with hepatic and renal insufficiency, hemorrhagic stroke and diathesis, hematopoietic disorders, during pregnancy and during labor, lactation. Contraindications are also age up to sixteen years and the risk of bleeding, including during the postoperative period.