Instructions for the use of "Flosteron": dosage, contraindications, analogues

"Flosteron" is a drug that helps slow the release of interleukins 1 and 2, as well as interferon gamma from macrophages and lymphocytes. This drug has immunosuppressive, antitoxic, anti-shock, desensitizing, anti-allergic and anti-inflammatory action.

The drug "Flosteron", the instructions for use of which will be clear to everyone, suppresses the release of the pituitary gland beta-lipotropin and ACGT. But there is no decrease in the level of circulating beta-endorphin. Also, the drug depresses the secretion of FSH and TSH.

The drug "Flosteron" increases the excitability of the central nervous system, while reducing the number of eosinophils and lymphocytes. The drug increases the number of red blood cells, stimulating the production of erythropoietin for this.

The drug "Flosteron", the indications for the use of which are very diverse, interacts with cytoplasmic specific receptors. As a result, a complex is formed that can penetrate into the nuclei of cells and stimulate the synthesis of mRNA, which induces the formation of protein, as well as lipocortin. This substance inhibits the phospholipase A2, while suppressing the release of arachidonic acid. Lipocortin also does not allow the synthesis of components such as leukotrienes, prostaglandins and endoperoxides, which actively contribute to the onset of allergic reactions and inflammatory processes.

Flosteron: indications for use

Injections of this drug are prescribed to combat various types of shock: anaphylactic, hemotransfusion, cardiogenic, toxic, surgical, traumatic, burn. In addition, the drug "Flosteron" is used in the occurrence of anaphylactoid reactions :

1. Swelling of the brain in tumors or after surgery, head trauma and radiation therapy.
2. Bronchial asthma in severe form.
3. Infections of connective tissues.
4. Lupus erythematosus.
5. Rheumatoid arthritis.
6. Acute kidney failure.
7. Poisoning cauterizing fluids.
8. Hepatic coma.
9. Acute hepatitis.
10. Thyrotoxic crisis.

The agent "Flosteron" (injections) is usually used intra-articularly. This therapy is used to combat osteoarthritis, Reiter's disease, ankylosing spondylitis, psoriatic and rheumatoid arthritis.

The drug in tablets

"Flosteron", the instruction for the application of which requires careful study, is produced not only in the form of injections, but also in tablets. They are most often prescribed in the presence of the following ailments:

1. Lupus erythematosus.
2. Diseases of connective tissue.
3. Nodular periarthritis.
4. Scleroderma.
5. Rheumatoid arthritis.
6. Dermatomyositis.
7. Chronic, as well as acute inflammatory processes that occur in the joints.
8. Psoriatic and gouty arthritis.
9. Bechterew's disease.
10. Juvenile arthritis.
11. Plechelohepatic periarteritis.
12. Osteoarthritis.
13. Polyarthritis.
14. Still's syndrome, but only in adults.
15. Nonspecific tenosynovitis.
16. Bursitis.
17. Epicondylitis and synovitis.
18. Rheumatic carditis.
19. Acute rheumatism.
20. Chorea.
21. Chronic as well as acute allergic ailments.
22. Bronchial asthma.
23. Medicinal exanthema.
24. Serum sickness.

The drug "Flosteron" in tablets can be prescribed for the treatment of some skin diseases, for example, with contact dermatitis, eczema, atopic, exfoliative, seborrheic and bullous herpetiform dermatitis, the Lyell syndrome and Stevens-Johnson syndrome.

Also, the drug in this form is used in complex therapy for edema of the brain, which can be metastatic, postoperative and traumatic (after previous parenteral administration). The medicinal product perfectly copes with allergic ailments of the eyes, for example, corneal ulcers, allergic form of conjunctivitis, as well as with some inflammatory diseases, including sympathetic ophthalmia, optic neuritis and the like.

The drug "Flosteron", the instruction to which contains a more detailed list of indications for use, allows you to get rid of the secondary and primary adrenal insufficiency even after their removal. The drug also struggles with kidney diseases: acute glomerulonephritis, nephritic syndrome.

Diseases of the hematopoiesis

The drug in tablets is prescribed for certain disorders in the work of the organs of hematopoiesis: erythrocyte anemia, in another way - erythroblastopenia; Secondary thrombocytopenia, but only in adults; Thrombocytopenic purpura; Lymphogranulomatosis; Acute myelogenous and lymphoid leukemia; Hypoplastic congenital anemia; Hemolytic autoimmune anemia; Agranulocytosis and other ailments.

What lung diseases treats

Very often, with diseases of the respiratory system designate "Flosteron". Instructions for use of this drug indicates that it can be used in complex therapy for lung cancer. In this case, the drug is prescribed in combination with cytostatics. In addition, the instructions for the use of "Flosteron" contain information that the drug helps in combating the syndrome of Leffler. He is appointed with this disease only if the other treatment does not help. Also, the drug is often used for Borreliosis, pulmonary tuberculosis, tuberculosis meningitis and aspiration pneumonia in combination with chemotherapy.

Contraindications to systemic use

Instruction for the application of "Flosteron" says that the drug with systemic therapy has some contraindications. Among them are the following: diabetes mellitus, acute psychosis, congestive heart failure, recent myocardial infarction, gastritis, esophagitis, diverticulitis, peptic ulcer during an exacerbation, active form of tuberculosis in the absence of specific specific treatment, immunodeficiency, suspected or fixed strongyloidiasis , Measles, chicken pox, systemic mycoses.

Contraindications when administered orally

The drug "Flosteron" (the instruction contains all the necessary information) has other contraindications. The drug should not be administered inside with unstable joints, abnormal bleeding, which may be a consequence of taking anticoagulants. Injection of "Flosteron" is prohibited in cases of severe articular osteoporosis, joint fracture of the bone, as well as with an infected lesion of intervertebral spaces, and periarticular soft tissues.

In what cases can not use the drug to treat skin and other ailments

Very often the drug "Flosteron" is used to treat certain types of dermatitis. However, in this case there are contraindications. The drug is prohibited for the treatment of rashes against the background of diaper rash in children under one year, with a postvaccinal reaction. In addition, Flosteron, the instruction for which contains a detailed description of all contraindications, can not be used for the treatment of common acne, and also in the presence of diseases such as sarcoma, xanthoma, hemangioma, melanoma, atheroma, skin cancer, fungal, viral and bacterial Diseases of the skin, herpes, trophic ulcers of the lower leg, which arose as a result of varicose veins.

You can not use the ampoules "Flosteron" for fungal diseases of the ears and eyes, perforation of the eardrums, with the previously transferred or chronic otitis media, glaucoma, sclera, corneal epithelium defect or with their thinning, bacterial infections of the ears and eyes, tuberculosis lesions of these organs, As well as viral acute diseases, for example, superficial keratitis.

Can I take Flosteron for pregnant women and during lactation

According to experts, strictly controlled and adequate research in this area was not conducted. Therefore, the reception of this particular drug is allowed to pregnant women only if the effect of therapy is higher than the risk for a future child. In this case, there are contraindications - pre-eclampsia, symptoms of placenta damage, eclampsia. It is forbidden to use this drug in large doses and for a long period.

With regard to the administration of the drug intramuscularly, in the setting of experiments on rabbits, some deviations in the development of the fetus were identified, among them cephalocele and umbilical hernia. The drug received category C by the FDA for action on an unborn child.

What to do in the lactation period? Experts recommend that women stop breastfeeding for the duration of treatment.

Side effects

Instructions for the use of "Flosteron" contains all the necessary data not only about the dosage of the drug, but also about its side effects. Their severity and frequency directly depend on the amount of medication used, as well as on the duration of admission. As a result of the application of "Flosteron", a glucocorticoid effect may occur. In any case, this is regarded as a side effect.

System Effects

Often in patients with the use of "Flosteron" there were such side effects as anxiety, confusion, disorientation, excitement, hallucinations, euphoria, paranoia, depression, pseudotumor of the cerebellum. There were cases when a patient during a course of therapy could feel a headache, vertigo, dizziness. Specialists note that as a result of treatment, subcapsular cataracts can develop and eye pressure increase, which ultimately leads to glaucoma, optic nerve damage and steroid exophthalmos.

Also, systemic effects are observed on the part of the organs of hematopoiesis and cardiovascular system. So, "Flosteron", the application of which must be agreed with the doctor, can cause changes in the ECG, which are typical for hypokalemia, thrombosis, hypercoagulation, myocardial dystrophy, chronic heart failure in predisposing patients, and arterial hypertension.

Precautionary measures

In patients with certain chronic diseases, which have the development of mental abnormalities, there may be violations of such a plan. This also applies to those cases where the dosage of "Flosteron" is very high. In this case, the symptoms may occur after several weeks or immediately after the start of the drug.

With caution, "Flosteron" should be taken to those who suffer from diabetes, herpes simplex cornea, systemic lupus erythematosus. In the latter case, the risk of aseptic necrosis increases. Also, the drug should be taken cautiously by the elderly, as the likelihood of developing hypertension and osteoporosis increases. This applies to the fairer sex in the post-menopausal period.

The action of "Flosteron" is enhanced with cirrhosis and hypothyroidism. Also, with prolonged admission of the drug, there is a chance of developing adrenal insufficiency. This phenomenon can be observed for several months after the end of the "Flosteron" reception.

With enough long-term therapy of some ailments in children, it is necessary to monitor the dynamics of their development and growth. For this, it is necessary to periodically perform an ophthalmological examination. This allows you to identify cataracts, glaucoma and other ailments. Experts recommend to constantly monitor the work of the hypothalamic-pituitary-adrenal system, and also to monitor the presence in the feces of hidden blood, the amount of glucose in the urine and blood, and electrolytes in the serum. This applies not only to patients with diabetes mellitus. If "Flosteron" is used systemically, then it is necessary to carry out EEG monitoring.

The drug, which is intended to treat skin diseases, should not fall on the mucous membranes, as well as in the eyes. During the period of Flosteron therapy, vaccination and immunization should be avoided.

How to calculate the dosage of the drug

If the patient requires the systemic use of glucocorticosteroids, then "Flosteron" (injections), the instruction recommends that you enter exclusively intramuscularly. There are other methods of using this drug. In some cases, intradermal, intraarticular and periarticular administration is required.

As for the dosage of the drug, it is prescribed by the doctor. The amount of the drug depends not only on the severity of the disease, but also on the age of the patient, the clinical response to appropriate therapy, and other indications. Typically, experts set the shortest period of taking "Flosteron" and the minimum dosage. Very often initially, the patient is assigned only 1 or 2 milliliters of medication per treatment.

Recommended dosage for intravenous administration

A solution for infusions is usually prescribed by drip or very slowly. In this case, a single dose should be from 4 to 8 milligrams, which corresponds to 1 and 2 milliliters, respectively. If necessary, the amount of the drug is changed. Dosage can be in some cases up to 20 milligrams, and supportive - from 2 to 4 milligrams. In this case, the drug is usually diluted with a solution of dextrose or 0.9% solution of sodium chloride. Prepare the preparation immediately before administration. If the solution has not been used for its intended purpose, then it can be stored for 24 hours in a cool place, preferably in a refrigerator.

Dosage for intramuscular injection

Instruction for the use of "Flosteron" does not allow you to determine the dosage yourself. Therefore, the preparation should be discussed with the attending physician. If the medication is used as intramuscular injections, then experts recommend that it be injected deeply. Usually, for serious illnesses, for example, asthmatic status or SLE, the doctor prescribes an initial dose of 4 to 8 milligrams. If the patient is a child of an age from one to five years, then another dosage is used. In this case, an initial injection of 2 milligrams is prescribed. In this case, the drug can be diluted. Children from 6 to 12 years of age are initially prescribed 4 milligrams.

"Flosteron" (injections) instruction allows the use of newborns in preterm labor. This is done to prevent hyaline-membrane disease. Usually the drug is administered before delivery, for 48-72 hours. In this case, the dosage should not exceed 8 milligrams. The second injection is performed a day later.

Dosage with periarticular and intravertual application

In this case, for the treatment of the largest joints, 4 to 8 milligrams of Flosteron are administered, for the middle joints, for example, the wrist or elbow joint, from 2 to 4, for large joints, for example, the shoulder, ankle and knee joints - up to 4, and for small - from 1 to 2. If treatment of skin ailments is carried out, then a single dosage should be approximately 0.2 milliliters per square centimeter. It is required to enter no more than 4 milligrams a week.

Dosage of the drug with local infiltration

With this method of using the drug, experts recommend adhering to the following dosages: with periarticular inflammation, peritendinitis, fibrositis and myositis - from 2 to 4 milligrams, with tendinitis - up to 2, with synovitis and synovial cyst, and bursitis - from 1 Up to 2.

special instructions

With special care, the "Flosteron" drug should be used. Instructions for the use of injections in ampoules or tablets advise to apply strictly in accordance with the prescribed dosage. Since the injections of this drug are very painful, it is allowed to dilute the drug in equal amounts with a solution of a local antiseptic. This is ideally suited to "Lidocaine" or "Procaine hydrochloride". At the same time, mix the solutions in a syringe, not in an ampoule.

During the application of the drug "Flosteron" it is necessary to control the process of recovery. To do this, you should regularly perform blood tests, glycosuria and glycemia. Constantly check the plasma content of electrolytes.

If the drug is used for the therapy of tuberculosis, septic status and intercurrent infections, it is necessary to simultaneously take antibiotics.

Children who are in constant contact with sick chicken pox and measles should be given a specific lg for the treatment period. Pregnant women, as well as those who feed their baby with breast milk, are given "Flosteron" only in view of the expected result, as well as the negative impact on the fetus.

Those children who are in a period of growth, usually prescribed such drugs only for life. In this case, the reception of "Flosteron" in this case should be carried out under the supervision of a treating specialist. It should be remembered that in patients with thyrotoxicosis, the clearance of GCS increases, and in patients with hypothyroidism, on the contrary, it decreases.

Which drug is best

What to prefer: "Flosteron" or "Diprospan"? In fact, these drugs are analogues. In their formulations there is one and the same main component, and they differ by additives. Often, one drug causes an allergy, while the other is perfectly suitable.

Do not change the drug yourself, as replacing "Flosteron" with a cheaper analogue may affect the health of the patient. It should be remembered that "Diprospan" has a higher bioavailability. Therefore, experts recommend using it in emergencies.

Analogues

Not all pharmacies can be found "Flosteron". Analogues can solve the problem. In the form of an ointment, funds "Akiderm" and "Beloderm" are released. There are analogues in other forms, such as Betamethasone valerate, Betamethasone sodium phosphate, Betamethasone, Betazon, Beloderm Express, Betnoveit, Betliben, Diprospan, Celestoderm-V, "Celederm", "Kuterid", "Celeston" and others. Replacement of the drug can be carried out only after consultation with a specialist who appointed "Flosteron". The analogue, as a rule, can be purchased only on the prescription of a doctor.