Instructions for the application of "Gepadif". Reviews and Analogues

What is a medicine like "Gepadif"? Instructions for use, feedback on the effectiveness of this drug will be discussed below. Also, from the presented article you will learn about what the indicated tool is for, what form it is issued in, what it contains, etc.

Composition, forms of release of a medicinal product

Currently, this medicine is produced in the following forms:

• A powder intended for the preparation of an infusion solution, which is placed in vials and packs of cardboard, respectively.

The composition of this drug includes carotene orotate, carnitine hydrochloride, antitoxic fraction, adenosine, pyridoxine hydrochloride and cyanocobalamin.

• The drug "Gepadif" - capsules. Instruction for use states that this form of the drug is produced in a dark brown case with the inscriptions Hepadif and HSD. Their contents are a fine powder of light yellow color with a brownish tinge. Gelatin capsules go on sale in contour cells and cardboard boxes, respectively. The composition of the medicament in question includes: carotene orotate, antitoxic fraction, pyridoxine hydrochloride, cyanocobalamin, adenine hydrochloride and riboflavin. It should also be noted that the agent contains the following excipients: iron oxide black, anhydrous lactose, iron oxide red, magnesium stearate, gelatin, iron oxide yellow, anhydrous colloidal silicon dioxide, titanium dioxide and microcrystalline cellulose.

Pharmacology of a medical device

What is the drug under consideration? What does the instruction for use say? "Gepadif" is a combined preparation. The mechanism of its action is due to the influence of constituent components.

The drug is able to stimulate the biosynthetic processes in the body and the processes of lipid metabolism, prevent necrosis of hepatocytes, normalize the proliferation of hepatocytes, restore normal liver function, and the production of specific enzymes.

Features of the medicinal product

What properties are inherent in the medicine "Gepadif"? Instructions for use asserts that the adenosine contained in the preparation is included in the nucleic acids, coenzymes and virtually all cells of the body. Moreover, it is an endogenous nucleoside and is able to regulate the processes of hematopoiesis. This component reduces the tone of the smooth muscle walls of blood vessels, and also normalizes the supply of O2 hepatocytes.

What role does the group B vitamins (pyridoxine, riboflavin, cyanocobalamin) play in this tool? Due to their presence the preparation "Gepadif" takes an active part in the synthesis of the most important amino acids (tryptophan, methionine, cysteine and others) and OVR. They also stimulate erythropoiesis and normalize fat, protein and carbohydrate metabolism.

The antitoxic fraction included in the drug contains a substitute and irreplaceable amino acids, due to which it has antioxidant and detoxifying effects.

With regard to carnitine, this component takes a direct part in the cleavage of fatty acids, the regulation of fat metabolism and normal digestion of food. It should also be noted that this substance can stimulate the production of bile, increase the sensitivity of cells to insulin and facilitate the absorption of carbohydrates in the intestines, which are extremely necessary to support its normal flora.

Kinetic Properties

How is the absorption of the medicine "Gepadif"? The use of the drug orally promotes the release of a complex of active components in the duodenum. After this, instantaneous absorption of carnitine, vitamins, antitoxic fraction and adenine takes place over the entire length of the small intestine.

The distribution of these substances is not only in the intestines, but also in the liver and kidneys. The maximum concentration of riboflavin is observed in myocardial cells.

The metabolism of pyridoxine is carried out in the liver. This component is distributed in the liver, as well as in muscle tissues and the nervous system. The products of metabolism are mainly excreted by the kidneys.

When the drug is administered intravenously, its substances are also distributed in the muscle tissue, liver, brain, kidneys and cardiomyocytes. Metabolism of the solution also occurs in the liver, and the products of metabolism are excreted through the kidneys.

Indications for taking capsules and using powder

What are the conditions for the patient to prescribe the medication in question? What does the instruction for use say? "Gepadif" is indicated for the complex therapy of the following diseases:

• Cirrhosis of the liver;
• Acute and chronic hepatitis;
• Fatty liver disease;
• Alcoholic liver damage;
• Exogenous poisoning;
• Intoxication, which was caused by long-term use of antitumor and anti-tuberculosis drugs.

Contraindications to the use of the medicine

When should you not apply the solution and capsules "Gepadif" (tablets)? Instruction for use informs that these funds are contraindicated for:

• Allergies to drug components;
• Erythema, nephrolithiasis, erythrocytosis and thromboembolism;
• Under the age of 7 years;
• Ulcer of the digestive tract (especially in the stage of exacerbation).

Instructions for use

"Gepadif" in the form of capsules is taken orally, washed down with water (whole). The dosage regimen of this remedy, as well as the duration of treatment, is determined only by the attending physician.

Usually the daily dosage of the drug for adults is two capsules three times a day. As for children from 7 years, they are prescribed three tablets per day (in 3 divided doses).

In the event that the patient has difficulty with the use of a single capsule, its contents are allowed to dissolve in a small amount of water or juice (only not in milk).

It should also be noted that if capsules are not available to the patient, intravenous administration of the drug is prescribed.

How correctly to do or make nyxes with a preparation "Gepadif"?

The instruction says that the daily dosage of the solution for adults is 8.625 mg per kilogram of body weight. Multiplicity of administration of this agent is 1 time per day.

Before the injection, the contents of the vial are dissolved with a 5% glucose solution in a volume of 500 ml.

Correction of the dose of the drug for the elderly is not required.

Side effects

What are the undesirable reactions caused by this medication? What does the instruction for use say? "Gepadif" is tolerated fairly well. Although in some cases they may still exhibit the following side effects: indigestion, headache, nausea, constipation, urticaria, yellow staining, vomiting, Quincke's edema, diarrhea, rashes on the skin.

Cases of drug overdose

When an overdose of this medication in the patient there are: peripheral neuropathy, diarrhea, increased adverse reactions, vomiting.

To treat such conditions, the affected person is prescribed gastric lavage and symptomatic therapy, as well as activated charcoal and saline laxatives.

Interaction

How does "Gepadif" interact with other drugs? Instruction informs that before taking this medication, it is necessary to consult with the doctor.

"Riboflavin" is forbidden to combine with "Streptomycin", since the first significantly reduces the effectiveness of antibacterial drugs. Also, the metabolism of the agent in question, including its effect on the heart, reduces tricyclic antidepressants.

Vitamin B6, which is part of the "Gepadif", weakens the action of "Levodopa" and reduces the manifestations of adverse reactions of antituberculous agents and "Isoniazid."

The assimilation of vitamin B12 is affected by alcohol, calcium preparations, para-aminosalicylic acid and "cimetidine".

Reviews and Analogues

There are many different analogues of "Gepadif". They can differ not only in price, but in composition. Such medicines include the following: Tavamin, Oktamin Plus, Heptor, Carnitine, Elkar, Carnivit, Almiba, Carnigel, Carniten, Le Carnita, Agvantar "," Stimol "," Heptral "," Steator ".

As it was said above, the medicament in question has a wide spectrum of action. Therefore, it is prescribed for various diseases. However, most often this drug is used as part of complex therapy to support the work of the liver.

Opinions of consumers about the effectiveness and effectiveness of this drug are divided. This is due to the fact that the result of therapy with this drug may be different, depending on the degree of organ damage, the type of disease and concomitant medication with other medications. Therefore, appoint this drug should only a specialist after a thorough examination of the patient.

It should also be noted that very many patients complain that when receiving "Gepadif" they often have side reactions in the form of problems with stools and nausea.