How to apply the drug "Cefazolin" (injections)

The drug "Cefazolin" (injections) is the first generation cephalosporin antibiotic, which has a bactericidal effect.

This drug is not intended for oral administration, as in this case it is destroyed. After this medication is administered, it penetrates well into tissues and organs, including the abdominal cavity, placenta, urinary tract, joints, kidneys, respiratory tract, middle ear, soft tissues, skin and cardiovascular system. The drug "Cefazolin" (injections) is excreted by the kidneys, and in the first 24 hours it is deduced up to 80%.

Indications for use

This drug is intended for use in the presence of such diseases:

• Peritonitis, sepsis, endocarditis;
• It is used in the presence of respiratory tract infections, as well as when there is an infection of the urinary tract;
• Syphilis and gonorrhea are also indications for its use;
• To combat infections that damage bones and joints;
• For the prevention of complications after various operations.

The medicine "Cefazolin" is a form of release

This drug is available in the form of a powder of white or slightly yellowish color, which is intended for intramuscular and intravenous administration.

Mode of application

This drug is only injected or drip. For adults, the daily dose should be from 0.25 to 1 gram, it is administered up to 4 times a day, but not more than 6 grams. Treatment with the drug "Cefazolin" (injections) can last up to 10 days.

For the purpose of prophylaxis one hour before the start of the operation, it is recommended to inject 1 gram of the drug intravenously, during surgery it is also introduced up to 1 gram and after it is completed, for every 8 hours, 0.5 to 1 gram of this drug should be taken every 8 hours.

For children aged 1 month, the daily dose should not be more than 25-50 mg / kg, in especially severe cases it can be increased to 100 mg / kg and is also administered 3-4 times.

In order to prepare a medicine "Cefazolin" (injections), take 0.5 mg of the drug and dissolve in 2-4 ml of sterile water, if administered intramuscularly, it can be diluted in novocaine. If the drug is administered iv, then it is diluted with 5 ml of water and injected for 5 minutes. On drip administration, this agent is diluted in a 5% or 10% solution of dextrose, which is taken 50-100 ml, or in a 0.9% solution of sodium chloride, Ringer's solution or sodium bicarbonate solution.

Before the introduction of the drug "Cefazolinum" in the ampoules should be vigorously and for a long time to shake, so that it mixes well.

Side effects

After applying this medication, such side effects may occur: bronchospasm, urticaria, pruritus, anaphylactic shock, abdominal pain, fever, diarrhea or constipation, stomatitis, pseudomembranous enterocolitis, genital itching, glossitis, candidiasis, phlebitis, anal itching , Granulocytopenia, hemolytic, anemia, leukopenia, thrombocytopenia, neutropenia, tenderness along the veins and superinfection.

Contraindications

The drug "Cefazolin" (injections) is not assigned to pregnant women and newborn children, with intolerance to cephalosporin group preparations, as well as beta-lactam antibiotics.

It should be noted that if a patient has an allergy to penicillins, they can also respond to cephalosporin antibiotics. The drug should be taken cautiously to those people who have such a gastrointestinal disease as colitis. Also, taking this medication can cause a false positive reaction to glucose in the urine.

Drug Interactions

The drug "Cefazolin" (injections) can not be used together with diuretics and anticoagulants. Incompatible this drug with aminoglycosides, as they mutually inactivate each other. During the preparation of a solution that will be administered intravenously, lidocaine can not be used.