"Diferelin": reviews, analogues and instructions for use

One of the most effective medicines intended to combat the worst pathologies of the female and male reproductive system is the drug "Diferelin". Instruction, the price of this drug is often discussed by patients in profile forums. As usual, and this drug has its adherents and opponents. In this article, we will consider the mechanism of action of this drug and its pharmacological features.

Pharmacological group

The drug "Diferelin" is a drug with an antigonadotropic effect. In fact, it is an antihormone, since it has the ability to inhibit the production of luteinizing and follicle-stimulating hormones in female and testosterone in men. Therefore, the drug "Diferelin" is actively used for the treatment of uterine myoma, endometriosis, prostate cancer, premature maturation in adolescents and other diseases.

Composition and form of release

The drug "Diferelin" is currently produced only in one dosage form - lyophilizate to create solutions. In this case, three versions of the drug are produced, differing in the concentration of the active substance and having different purposes:

• "Diferelin" 11.25 mg and 3.75 mg - for intramuscular injection;
• "Diferelin" 0.1 mg - for subcutaneous injection.

In everyday life, doctors and patients briefly refer to the aforementioned varieties of the drug, adding to its name the numbers indicating the content of the main substance in it.

As an active ingredient in the drug "Diferelin", reviews of which are mostly positive, triptorelin appears pamoate. It is he who exerts a pronounced therapeutic and pharmacological effect on the patient's body.

The drug "Diferelin" is sold in cardboard packages, in which there are vials with lyophilizate and a syringe with two needles. In addition, they contain ampoules with a solvent. It can be different. If for lyophilizers "Differelin" 3.75 and 11.25, mainly mannitol is used, then for a drug in a concentration of 0.1 mg, physiological saline is most often used .

The therapeutic effect of "Diferelin"

From a biochemical point of view, this drug is an analogue of the hormone GnRH, synthesized by the hypothalamus. It affects the pituitary gland responsible for the production of sex hormones and thereby regulates the work of the organs of the female and male reproductive system: the prostate gland, the ovaries, the uterus, and the testicles. It turns out that the level of production of sex hormones regulates the drug "Diferelin".

Reviews of its use indicate that it has a pronounced antitumor and antigonadotropic effect and is effective in the treatment of certain pathologies. For example, with infertility, this medicine suppresses the production of luteinizing hormone, which adversely affects ovulation, thereby increasing the likelihood of pregnancy. And with prostate cancer, this drug lowers the testosterone level to a zero mark, characteristic of eunuchs, and increases the patient's chances of getting rid of a malignant neoplasm.

Effective magic "Diferelin" and with endometriosis. By his influence on the production of sex hormones, he gradually introduces a woman into the artificially created state of menopause and thereby provokes atrophy of endometriotic foci.

Indications for use

Depending on the concentration, the drug "Diferelin" has a different effect on the body. The use of this drug in medicine depends on the content of the main active substance in it. For example, injections of "Differelin 0.1 mg" are indicated in infertility, to activate the ovaries and stimulate ovulation with IVF.

The use of this drug in a concentration of 3.75 mg is useful in the fight against prostate cancer, uterine fibroids, premature maturation, genital and extragenital endometriosis, IVF protocols.

In the most serious cases, with prostate cancer with metastases and chronic endometriosis, the appointment of "Diferelin 11.25 mg" is prescribed. Its use significantly increases the patient's chances of recovery.

Instructions for use

The drug "Diferelin 0,1 mg" is used in short and long protocols of IVF under the strict supervision of a doctor. It begins to be administered every day by one ampoule, starting from the second day of menstruation. The duration of such therapy is determined by the individual characteristics of the female body.

But the drug "Diferelin 11.25 mg" is administered to patients every three months. And men can make this injection at any time, and women - only in the first five days of the menstrual cycle. Duration of treatment with this drug lasts from three to six months, since it is not recommended for more than six months.

The widest range of uses for the drug "Diferelin 3.75". The patients' testimonies attest to the extreme effectiveness of this drug. In addition, it is very convenient to use, since it does not require daily administration for a long period of time. Injections of the drug "Diferelin 3.75 mg" are usually done once a month. This is enough to ensure the flow of active substance into the bloodstream in therapeutic dosages. Let us consider in more detail the scheme of application of this medication in relation to various diseases.

Prostate Cancer

For men, prostate cancer is treated with the drug "Diferelin". Patients are injected once every twenty-eight days in such a way that the interval between injections is four weeks. A single dose of the drug - one bottle of 3.75 mg. The duration of the medication is determined by the speed of the patient's recovery.

Endometriosis

Injections of the drug "Diferelin" in endometriosis are found in the first five days of the next menstruation. Follow-up medication is given after four weeks, and the course of therapy lasts a total of 3 to 6 months. It should be remembered that this medicine can not be combined with the use of oral contraceptives.

During the treatment of endometriosis, an artificial climax (amenorrhea) is caused by the drug "Diferelin". The patient's feedback, however, suggests that after the cessation of treatment, the menstrual cycle recovers within a few months, sometimes a full year. Repeated therapy with this drug for relapses of endometriosis, as a rule, is not prescribed - for this, other, equally effective medications are used.

Premature puberty

Children with the arrest of premature puberty drug "Diferelin" is prescribed once in 28 days. In this case, a single dose of its use is calculated taking into account the patient's body weight. Children weighing more than 20 kilograms are given a whole vial (3.75 mg), and children with lower indices have half an ampoule (1.875 mg). The duration of therapy is determined by the attending physician depending on the rate of normalization of the patient's condition.

Fibromyoma of the uterus

In the treatment of this disease, once a month, one bottle of "Diferelin" is administered. And his reception should be carried out during the first five days of the patient's menstrual cycle. Subsequent injections of the drug occur every four weeks. The duration of therapy usually does not exceed three months.

Overdose

At present, there is no case of overdose with the drug "Diferelin". The patient's feedback also indicates his relative safety. In addition, this drug does not affect the concentration of attention and the ability to control moving mechanisms. Therefore, during the course of therapy with this medicine, you can safely drive.

Adverse events

When using the drug "Diferelin" the following side effects may occur:

• Symptomatology of compression of the spinal cord;
• Increased pain;
• Quincke's edema, hives, itching;
• Obstruction of ureters;
• headache;
• Demineralization of bones;
• Decreased potency;
• Dryness of the vagina;
• Sweating;
• Decreased testes;
• Change of breast size;
• Hypogonadotropic amenorrhea;
• Hypertrophy of the ovaries;
• Menorrhagia;
• asthenia;
• nausea, vomiting;
• Hypertension;
• Tides;
• Visual impairment ;
• Emotional lability;
• Hematuria;
• The appearance of excess weight;
• Peripheral edema;
• fever;
• anorexia;
• depression;
• tachycardia;
• alopecia;
• Dyspnoea;
• Hyperemia of the injection site;
• Paresthesia.

Contraindications for use

The medicine "Diferelin" has separate contraindications for use. They are related to the patient's state of health, as well as to his individual physiological characteristics. For example, men should not take this drug with hormone-independent prostate cancer and after removing the testicles, and it is not recommended for women during pregnancy, lactation and polycystic ovary syndrome. All without exception, it is necessary to use with caution the drug "Diferelin" for osteoporosis and hypersensitivity to its components. In case of any negative symptoms, the patient should consult a doctor immediately.

General condition after application

As already mentioned above, the drug "Diferelin" suppresses the production of sex hormones in women and men, thereby introducing them into a state of artificial castration. Of course, immersion in this state and the way out of it is accompanied by various psychological, endocrine-metabolic and neuro-vegetative disorders.

After completion of the course of therapy with this drug, the hormonal background is restored, but during this process the patient may be concerned about irritability, fatigue, headaches, sweating, hot flashes, depression, fever and other unpleasant symptoms. However, within one and a half months after the end of the drug, the patient's physical condition is completely normalized. That is, usually after the last injection of "Diferelin 11.25 mg" the balance of hormones is restored after 4.5 months, and the action of the drug with a concentration of 3.75 mg ends after 2.5 months. For the specified periods of time, women and men are fully rehabilitated by reproductive and sexual functions and come to norm libido.

Application in pregnancy

When carrying a child, treatment with "Diferelin" is contraindicated. However, this medicine is actively used to activate ovulation. Many women could become pregnant after several injections of the drug, but, not knowing about it, continued to take the medicine "Diferelin". The effect of this medicine, as it was possible to establish, does not harm the future child: does not provoke the risk of miscarriage and does not promote the development of congenital malformations. However, the mechanism of the effect of this drug on the female reproductive system during pregnancy still requires careful study.

Analogues of the drug "Diferelin"

On the modern pharmaceutical market there is only one drug-synonym, having in its composition the same active substance - it is "Decapeptil". In addition, pharmacies can be found drugs that have the same therapeutic effect as the drug "Diferelin." A similar effect on the body is provided by the spray "Buserelin", lyophilizate "Buserelin Depot", capsules "Zoladex", preparations "Eligardt" and "Lucrin Depot".

Reviews

There are both positive and negative feedback about the use of the drug "Diferelin." The injections with this drug have a different effect on the patients. Many women, although they note a pronounced therapeutic effect in the treatment of fibroids and other diseases, but complain of side effects, which were hard for them in the process of treatment: weight gain, hot flashes, irritability, fatigue. At the same time, all patients agree that a difficult test of drug therapy is still preferable to cavitary surgery.

In the treatment of prostate cancer and other pathologies in men also there are conflicting reviews about the action of the drug "Diferelin." The price of the drug seems to be acceptable to many, the method of application also does not cause censures, and its effectiveness is composed of laudatory odes, because it not only removes the neoplasm itself, but also eliminates metastases in the bones. However, there are also negative comments about the drug "Diferelin", due to two main reasons: the low effectiveness of the drug in certain specific cases and side effects, which are difficult to tolerate by some patients and force them to stop therapy or completely drop out of the usual rhythm of life.

Price list

What is the cost of the drug "Diferelin"? The price of this medicine varies depending on its variety, the pharmacy network in which it is sold, and the mark-up on the product. So, in the modern market, the cost of seven bottles of "Differelin 0.1 mg" varies between 2597-3107 rubles. A large dosage will require more serious financial investments: for 1 bottle of "Diferelin 3.75 mg" the buyer will have to pay from 7632 to 9076 rubles. Naturally, the most expensive drug is a drug of greater concentration. One ampoule of "Diferelin 11,25 mg" can be bought for 18 269-23 100 rubles.

The price for the drug "Diferelin" is quite high. Similar funds are cheaper, but their appointment can be entrusted only to an experienced doctor, because they have completely different pharmacological features, contraindications and side effects.

Conclusion

Now you know all about the properties of the drug "Diferelin." This hormonal drug is effective against many diseases, but can cause a lot of side effects. Before the beginning of the course of treatment, each patient should be prepared for the fact that such therapy can be a difficult test for him. However, every risk is justified, if the card is health, and sometimes the life of a person. Therefore, you should not abandon the use of the drug "Diferelin" or replace it with cheaper analogs. It is better to start treatment with the most effective means and thereby ensure its favorable outcome. Be healthy!