Cream "Differin": instructions for use, composition, reviews

What is the cream of "Differin" for? The composition of this tool, its indications, release forms, contra-indications and methods of application will be described in detail in this article. In addition, we will tell you about how this medicine works on a person, whether there are side effects after using it, how much it should be applied, how much it costs and so on.

Forms of medical preparation and its composition

At present, there are two different forms of the drug under consideration in the pharmacy chains:

• 0.1% cream from black dots "Differin". The active ingredient of this drug is adapalene. The medicament also contains auxiliary components such as sodium hydroxide solution (10%), methyl glucose sesquistearate, carbomer 934P, sodium edetate, polyethylene glycol-20, phenoxyethanol, glycerol, cyclomethicone, natural perhydroscvalene, distilled water, methyl parahydroxybenzoate and propyl parahydroxybenzoate. Cream "Differin" is sold in pharmacies in tubes of 30 grams, which are placed in cardboard packs.
• 0.1% gel "Differin". Its active substance is also adapalene. As for the additional elements, they are carbomer 980, phenoxyethanol, propylene glycol, sodium hydrochloride, poloxamer 182, distilled water, sodium edetate and methyl parahydroxybenzoate. For sale, the gel comes in plastic tubes of 30 grams, which are placed in cardboard packs.

Pharmacological action of a medical preparation

What is the medicine "Differin" (cream)? The instruction for this drug, which is embedded in cardboard packaging, contains information that adapalene (the active substance) belongs to a new generation of synthetic retinoids. Specialists say that it is a derivative of naphthoic acid.

One can not ignore the fact that adapalene has anti-inflammatory, sebostatic, comedonolytic (or anticomedogenic) properties.

The drug we are considering can easily affect follicular hyperkeratosis with simultaneous regulation of desquamation and keratinization.

Cream of acne "Differin" has a pronounced comedonolytic activity and anticomedogenic effect. In other words, it affects closed and open comedones, and also prevents the formation and development of micro-comedones.

Principle of action of the medicinal product

The main mechanism of the drug is selective binding to nuclear RA-gamma receptors of epidermal cells. This fact significantly distinguishes cream "Differin" from the means of the previous generations, which linked retinoids indiscriminately.

The described mechanism of the drug regulates the final differentiation of keratinocytes. This drug is able to normalize the process of keratinization and reduce the prerequisites for the formation of microcosmodes.

Scientists have been shown the pronounced anti-inflammatory effects of adapalene. The drug inhibits lipoxygenase, arachidonic acid and cytokines. It exhibits very high anti-inflammatory properties, which, in terms of their effect, are comparable only with medicines Indomethacin and Betamethasone.

The active substance of the preparation does not possess a photosensitizing effect.

Pharmacokinetics of the medicine

Due to reduced systemic absorption there is no information on the pharmacokinetics of the drug. Also, there is no systemic effect on the body.

What indications for use is the drug?

Gel and cream "Differin" can be prescribed to patients in the following cases:

• With acne;
• With acne;
• With black dots on the face.

What are the contraindications to the use of the drug?

Gel and cream from black dots "Differin" has no contraindications. However, it should not be used in patients who have a high sensitivity to adapalene, as well as additional substances that are part of the drug. If you neglect this advice, then the skin allergic reactions may appear. In this case, the use of the drug should be immediately discarded.

Drug drug "Differin" (cream): instructions for use

How should I use the medication we are considering? Gel or cream from acne "Differin" is applied to the affected areas of the skin evenly. In this case, the drug should be carefully rubbed. The skin before applying the gel or cream is recommended to be rinsed with a soap solution beforehand, and then carefully dry with a tissue.

Usually the drug is prescribed once a day. Apply it to affected areas of the skin preferably immediately before bed. As a result of this treatment, the therapeutic effect will not take long.

Judging by practice, the result of using the medical preparation "Differin" is observed after 4-8 weeks of therapy. A more stable improvement is observed after about 3 months from the beginning of treatment.

If necessary, a repeated course of therapy with the drug may be performed. However, it should be done only on the advice of specialists.

The medicine "Differin" (cream), whose composition would be presented to your attention at the very beginning of the article, is allowed to be used for dry and sensitive skin.

Is it possible to combine the drug with other agents?

Now you know what a medical device like "Differin" is. Cream or gel to choose for the treatment of dermatological diseases? Experts argue that there is no difference between the named forms of the drug. However, most patients give preference to the cream. This fact is associated with the convenience of its use and a pleasant structure.

The drug "Differin" considered by us is indicated for the treatment of acne of medium and mild severity. As a rule, it is used as a monotherapy. Although acne of moderate severity is often treated in combination with other local remedies (for example, antibiotics, benzoyl peroxide and so on). In addition, in the therapy can be included and systemic drugs (for example, antiandrogen for oral administration, antibiotics).

Cases of overdose

Have there been cases of overdose with the drug "Differin"? Due to reduced systemic absorption, an overdose of this medication is impossible or unlikely.

Interaction with other medical devices

To date, there has been no clinically significant interaction of the cream or gel "Differin" with its simultaneous use with benzoyl peroxide or clindamycin phosphate.

Breastfeeding and Pregnancy Time

Is it possible to use the drug "Differin" during the gestation period? Cream or gel during pregnancy are contraindicated to the same extent. Also, a medical product should never be used during breastfeeding, as it can harm a baby's health.

Side effects from the use of medicament

Can the medical preparation "Differin" (acne cream) cause side effects? Feedback from those who periodically use this tool, says that sometimes the drug becomes the cause of the emergence of local reactions, such as peeling of the skin and their redness. However, the local allergy is manifested only if the gel or cream has been applied in excessive amounts. Therefore, for safety reasons, they should be used strictly according to the instructions.

Special instructions on the use of the medicinal product

During the application of the gel or cream "Differin" it is necessary to avoid getting it on the lips and eyes. If this still happens, then the mucous membranes should be rinsed immediately with warm water. If these rules are not observed, local allergic reactions in the form of redness and swelling are possible.

In some cases, during the use of the medication, the patient may show a brief irritation of the skin. In this case, the therapy should immediately be discontinued. After the disappearance of signs of irritation treatment can continue.

During the use of cream or gel "Differin" it is recommended to avoid active and long stay in the sun. Also, during the treatment period, you should avoid ultraviolet irradiation (visits to the solarium). If these recommendations are not followed, a slight irritation of the skin is possible.

During the use of a medical product, it is highly undesirable to use cosmetic products that have drying or irritating properties. In addition, the use of perfumes and other ethanol-containing products should be discarded.

To obtain the best therapeutic effect, some specialists recommend using other means to treat acne. In this case, the cream or gel "Differin" must be used once a day, at bedtime. In the morning, other drugs should be used (for example, 1% clindamycin lotion, 4% erythromycin lotion, and benzoyl peroxide water solution, the concentration of which does not exceed 10%).

It is allowed to simultaneously use makeup and moisturizing cosmetics, which do not contribute to the formation of comedones.

Terms and conditions of storage of a local preparation

According to experts, adapalene is an active substance that is resistant to light and oxygen. It is also chemically inactive.

It is recommended to store the gel in a place inaccessible to children at a temperature of no more than 25 degrees. Its shelf life is three years.

As for the cream, it should also be stored in a darkened cabinet, where the air temperature does not exceed 25 degrees. Freeze this drug is prohibited. Otherwise, it will lose all its therapeutic properties. Shelf life of the medicinal product is two years. After this period, use the product is strictly prohibited. The same goes for the gel.

The drug "Differin" is released in pharmacies without a doctor's prescription. However, it is not recommended for self-medication. Before use, always consult a doctor.

The cost of the facility, its analogs

The price of the drug we are considering is quite high. So, for one tube of cream (30 g), you will have to pay about 750 Russian rubles. The cost of the gel is similar (sometimes it can be a little higher).

If the drug "Differin" you can not afford, then it can be replaced by cheaper analogues. Among them, I would like to highlight the gel "Clenzite S". Its price is two times lower.

Reviews of the local product

In general, reviews about the cream and gel "Differin" are positive. Patients claim that if used correctly, it really eliminates acne, blackheads and black dots on the face. But, in order to avoid skin irritations, you should always consult a dermatologist before using the product.