"Budenit" for inhalations: instructions for use, description, composition and reviews

In the treatment of bronchial asthma, along with beta-adrenoreceptor agonists, inhalation glucocorticosteroids are widely used, which reduce the incidence and severity of bronchospasm attacks. Among this group of drugs should be allocated "Budenit" for inhalations. Instructions for the application of Budenita contain comprehensive information on the use of the drug, therefore we will pay attention to the consideration of its key features and technical nuances in the use of nebulizer therapy.

Composition of "Budenit Steri-Neb" (suspension)

The instruction says that the preparation is a suspension for inhalation, devoid of color and odor, packed in 2 ml polyethylene ampoules containing 1 mg (0.5 mg / ml) or 0.5 mg (0.25 mg / ml) Active substance budesonide. This substance belongs to the pharmacological group of glucocorticoid hormones for topical application.

Pharmacodynamics

As evidenced by the preparation "Budenit" for inhalation instructions, budesonide (the main active substance) has anti-allergic, anti-inflammatory and anti-edematous effect. By stimulating the production of lipocortin protein budesonide exerts a depressing effect on the synthesis of phospholipase, which in turn leads to a decrease in the synthesis of arachidonic acid, a decrease in the production of prostaglandins and leukotrienes. These processes at the cellular level lead to a decrease in the production of cytokines, reduce the migration of macrophages and lead to a decrease in cellular infiltration. Ultimately, this leads to a decrease in the level of mediators of inflammation, which positively affects the relief of asthma attacks and the stabilization of its clinical course.

As testifies about the preparation "Budenit Steri-Neb" instructions for use, its regular use leads to the restoration of the sensitivity of the bronchial tree to medicines that dilate the bronchi. This, in turn, reduces the frequency of application of the latter, reduces the amount of sputum produced by sputum, reduces sensitivity to allergens, which also has a positive effect on the clinical course of the disease.

The drug does not have mineralocorticoid activity, and also does not have systemic effects due to local action, which reduces the frequency and severity of side effects, is well tolerated with prolonged use.

As indicated by the medication "Budenit Steri-Neb" instructions for use, the analogs of this drug are also well tolerated and do not cause side effects associated with the use of systemic glucocorticosteroids.

After a single application, the therapeutic effect develops after several hours, reaching a maximum severity in 1-2 weeks after the start of use. The drug can be effectively used to prevent the onset of bronchial asthma physical stress, but due to the long latency period, the onset of therapeutic action is almost not suitable for the relief of acute conditions accompanied by bronchospasm.

Pharmacokinetics

The drug is injected with a nebulizer. After inhaling a fine aerosol, budesonide settles on the surface of the bronchial tree. About 15% of the drug due to absorption in the lumen of the bronchial tree enters the systemic circulation and is further metabolized by the cytochrome system to practically inactive metabolites (their activity is 100 times less than that of the starting material). About 70% of the drug is excreted by the kidneys, about 10% is excreted through the intestine.

Indications for use

As a basic drug, budesonide and its analogs are indicated for the treatment and prevention of asthma attacks, with ineffective use of selective beta-adrenomimetics to prevent the onset of the disease and stabilize the clinical picture, and to reduce the therapeutic dose of oral glucocorticoid agents. The drug is successfully used to treat stenosing laryngotracheitis and chronic obstructive pulmonary disease.

Contraindications

"Budenit Steri-Neb" (suspension for inhalation) is contraindicated in the presence of allergic reactions to one or more of the components that make up the drug, as well as to children under the age of 6 years. With great care, the drug is prescribed for pulmonary tuberculosis, respiratory damage to the viral, bacterial, fungal microflora, impaired liver function. The prohibition of the use of the drug in the presence of infectious diseases is due to the local immunosuppressive effect on the mucosa, which may entail a decrease in the immune response and the progression of the disease.

Side effects

Due to the fact that the drug is administered by inhalation with the help of a nebulizer, there is a high probability of dryness of the oral mucosa and upper respiratory tract, sensation of perspiration in the throat and irritation, unusual and unpleasant gustatory sensations, hoarseness or hoarseness of the voice, coughing. This is due to the settling of microparticles of the drug on the surface of the mucosa.

Quite rare are violations of the nervous system, which manifest themselves in the form of nervousness and increased neuropsychic excitability, impaired behavior, headache. In addition, patients who apply Budenit sometimes notice the occurrence of allergic reactions in the form of urticaria, itching or redness of the skin, spasm of the smooth muscles of the bronchial tree, and the development of candidiasis of the oral cavity and esophagus.

The occurrence of paradoxical bronchospasm and progressive dyspnea after the onset of inhalation of the first dose is due to the irritant effect of the drug on the respiratory mucosa. With the development of this side effect, inhalation is recommended to stop and prescribe an alternative therapy.

Despite the low bioavailability of the drug and its predominantly local action, with prolonged use, it is possible to develop systemic effects of glucocorticosteroids. This is manifested by the oppression of the adrenal cortex, the slowing of growth in children, the reduction of bone mineral density, the development of visual impairment.

In some cases (very rarely), irritation of the facial skin may occur when using a nebulizer mask. In order to prevent this complication, disinfectant solutions should be used for the mask, and after inhalation, wash the face skin with running warm water. It is also possible to loosen the tension of the gum that holds the mask on the face. A good alternative may be the use of a mouthpiece or mouthpiece for inhalation.

Use during pregnancy and lactation

Instruction on "Budenit" recommends caution in prescribing the drug in pregnant women, as well as during breastfeeding (although there is no data on the drug's entry into the mother's milk). The drug is recommended to use only if its benefit to the mother exceeds the possible negative consequences and complications for the fetus. In this case, budesonide should be used in a minimally effective dosage, which makes it possible to fully control the course of the disease.

Drug Interactions

At the level of pharmaceutical interaction, the drug is fully compatible with isotonic sodium chloride solution, as well as other inhaled beta-adrenomimetics, mucolytics and expectorants. In order to improve the effectiveness of treatment and therapeutic effect in the management of bronchial spasm, the preparations of these groups can be placed together in the nebulizer chamber. The joint use of bronchodilators not only improves the entry of Budesonide into the bronchoalveolar tree, but also contributes to its deeper penetration through the lumen.

Due to the involvement of cytochrome P450 enzymes in budesonide metabolism, the dose of the drug should be reviewed when using drugs that depress or stimulate the activity of this enzyme. It is not recommended to use the drug jointly with antifungal drugs such as Ketoconazole and Intraconazole, as this may lead to an increase in Budesonide concentration in the plasma.

Medicines that increase the activity of microsomal enzymes ("Phenobarbital", "Phenytoin", "Rifampicin"), reduce the activity of Budesonide.

Mode of application

It's quite easy to use Budenit for inhalations. Instructions for use indicate the need for a nebulizer for therapy. The drug is placed in the nebulizer chamber of the device, and inhalation is performed. Duration of inhalation and dosage should be selected in each case, taking into account the clinical condition and severity of the patient's illness when using the drug "Budenit" for inhalations. Instruction for children from 6 months to 12 years indicates the appointment of budesonide at half the dosage. For patients over 12 years of age, the maintenance dose should be selected individually.

If necessary, the combination of "Budenita" with oral glucocorticoid drugs is recommended to increase the dose of "Budenita" in order to prevent the occurrence and decrease the severity of side effects.

Reviews

The attending physicians and patients are satisfied with the efficacy of the drug. This is evidenced by each review of (a suspension for inhalation Teva "Budenit" - a fairly popular drug) drug. A positive attitude towards it is formed by a low incidence of side effects and high effectiveness of treatment. Opinions about the preparation "Budenit" for inhalations for children (instructions, dosages are given in the article) are positive in mothers, which is also due to the low incidence of side effects. Painless inhalation with nebulizers (which can be performed in the form of various toys) in young children also speaks in favor of using this medication or its analogues.

Overdose

In acute overdose of the drug, severe clinical symptoms are not observed. Treatment is symptomatic, with withdrawal of the drug and the appointment of bronchodilators of a short type of action.

It should be borne in mind that with the long-term use of Budenit in doses exceeding the average therapeutic levels, it is possible to develop side effects at the systemic level (hypercorticism, oppression of adrenal function). This is indicated by the preparation "Budenit" for inhalation instructions. Its price is available for long-term use of this medication as the main for the therapy of bronchial asthma.

Separate directions and recommendations

The instruction on the use of the preparation "Budenit" says that it is not intended to relieve an acute attack of bronchospasm. The average time of development of the therapeutic effect is about 10 days, but it can be increased if there is a large amount of mucus or a viscous secretion in the lumen of the bronchial tree. In such a case, treatment with oral glucocorticoids is possible, followed by a transition only to Budenit Steri-Neb for inhalations.

The instruction to the drug says that, although the probability of occurrence of side effects at the system level is much lower, the minimum effective therapeutic dose must be titrated for the maximum effect. When using the drug in children, in order to detect the development of side effects in a timely manner, one should constantly monitor the growth of the child for a long period of time. With the development of side effects should reduce the dose to the least effective, which allows you to monitor attacks of bronchial asthma.

To prevent the occurrence of a fungal infection in the oral cavity, the patient should be informed of the need for rinsing the oral cavity and removing the remnants of the drug after each inhalation. This contributes to the restoration of local immunity of the oral cavity and mucous membranes.

Technical features of use

Inhalation of "Budenita" with the help of ultrasonic nebulizers is contraindicated. The effective dose of the drug should be calculated taking into account the technical characteristics of the specific nebulizer (taking into account the air flow rate, the volume of the nebulizer chamber, etc.) and the patient's condition.

Before using the drug "Budenit" for inhalations in a nebulizer, the instruction of a nebulizer must be studied without fail. This will avoid improper connection of the device and inefficient use of the drug. If the nebulizer is used for the first time, it is recommended to try it with the use of physiological sodium chloride solution, make sure it is working and then used with medications.

Before the inhalation, a plastic ampoule is removed from the box, it is opened by peeling off the lid, the drug is placed in the nebulizer chamber of the device, the mask is put on the face (or the mouthpiece is clamped) and the airflow is supplied. When carrying out inhalations with the aid of the mouthpiece, one should breathe only through the mouth (a special clip is put on the nose). When using a respiratory mask, the use of a nasal clip is optional.

For inhalation it is recommended to use a nebulizer camera with a valve device that ensures the injection of a fine aerosol of the drug directly at the time of inspiration and closes the exit of the drug at the time of exhalation. This increases the delivery of the drug to the bronchoalveolar tree and reduces the loss of the drug upon exhalation.

"Budenit Steri-Neb": analogues, price

Analogues of the medication "Budenit Steri-Neb" are such drugs as "Pulmicort" and "Pulmicort Turbuhaler", "Cortimen", "Tafen", "Budostere", "Budenofalk" and many others. With these medications, as with Budenit for inhalations, the instruction is identical because of the presence of the same active substance. The cost of these drugs depends on the pharmacy network and the region, as well as on the dosage. On average, the price ranges from 650 to 2550 rubles.

Conclusion

A highly effective drug for the treatment and prevention of asthma attacks is Budenit for inhalations. The instruction to the preparation gives exhaustive information about the dosage and the conditions of application of this drug. Given the use of budesonide in accordance with the instructions and recommended dosages, the drug provides effective treatment. If for some reason you can not purchase the original, there are analogues. "Budenit Steri-Neb" (the price, the instruction is now known to you) will save you from many diseases of the respiratory system.