Bad coagulability of blood.

Today, a clotting disorder can be a consequence of a number of diseases as the blood itself (hemophilia, thrombocytopenia, Villebrant's disease and others), and vascular disease (various vasculitis).

What is clotting? And why is its violation?

Blood, as a liquid environment of the body performs the basic functions assigned to it. First of all, it is the transfer of oxygen and nutrition of tissues. To maintain normal functioning of the body the main thing is to maintain homeostasis. The internal environment of the organism is variable and under the influence of certain influences, appropriate transformations take place in it, contributing to adaptation and survival - this is homeostasis.

Bad coagulability of blood is none other than a defect in one of the homeostasis systems. Normally, the processes of clotting and formation of blood clots (thrombi) and their lysis (dissolution) are constantly occurring in the human body. When there are injuries of the skin or other tissues of the body, the whole cascade of consecutive reactions is activated. Since in the process of formation various substances, like cellular ones (that is, those that separate from the destroyed cells, informing the coagulating system of tissue integrity violation), and non-cellular factors (factors) participate in the formation of the thrombus on the wound surface. The latter are synthesized mainly in their volume in the liver, so poor coagulability of the blood most often indicates abnormalities in the functioning of this body. Often, the disease can be caused by a hereditary pathology in diseases such as Villebrant's disease and hemophilia.

Most of the blood coagulation factors are synthesized from protein (various amino acids), which is why when it is insufficiently supplied with food, poor blood coagulation also develops.

Treatment of this pathology, in the first place, is aimed at eliminating etiological factors, that is, eliminating the causes of the disease that caused it. If there is no possibility of influencing the etiologic link, the pathogenetic effect is applied, which implies an impact on the mechanisms of development of the pathological condition. However, even these two variants of the mechanisms of therapeutic influence do not always cause the disappearance of symptoms and poor coagulability of the blood is not eliminated. In this case, another version of the effect is applied not to pathology, but to optimizing the environment (homeostasis) at the moment.

However, speaking about this pathology, we can not fail to mention such a condition as high blood coagulability. This state occurs much less often than the previous one, but it is not worth neglecting it, since the possible consequences can be very serious. Among the reasons leading to thickening and, as a result, an increase in blood coagulability, we can distinguish the following:

- profuse fluid loss as a result of polyuria (frequent urination), vomiting (often repeated and uncontrollable) or massive burns (as a result of sweating blood plasma on the wound surface)

- the presence of fermentopathy or invasion leading to a change in SCR

- Pregnancy (physiological changes in blood rheology)

- liver disease (violation of the synthesis of enzymes and hormones)

- syndrome of disseminated coagulation inside the vessels

Increased coagulability can lead to blood stasis and the formation of blood clots inside the vessels. Such a process causes the occurrence of ischemia of thrombosed organs and tissues. Treatment in this case is represented by the administration of drugs that dissolve blood clots (for example, streptokinase or alteplase) and blood thinners. In the event that the thrombus completely limited the blood circulation in the organ, necrosis occurs.