"Avodart": the instruction, responses. "Avodart" (tablets): the price

What do you know about Avodart? Analogues, price, indications and instructions of this tool will be presented in this article. Also you will learn about what properties are inherent in this medicine, what pharmacological group it belongs to, what it is part of, etc.

Form, description, packaging and composition

The drug Avodart is available in the form of soft gelatinous oblong and opaque capsules of yellow color, marked with the code "GX CE2". On sale this medication can be found in cardboard boxes, where blisters are placed with 90 or 30 tablets.

Dutasteride acts as an active element of the agent under consideration, and gelatin, butylhydroxytoluene, triglycerides, titanium dioxide, red ink for printing, mono-diglycerides of caprylic acid, glycerin, lecithin and ferric oxide are used as additional constituents.

Pharmacodynamic characteristics

What is the pharmacological group of Avodart? Instruction for use says that this antiandrogenic remedy. Its active substance is a double inhibitor of the enzyme 5-alpha-reductase. This component is able to inhibit the conversion of testosterone to DHT. This is due to the suppression of the activity of 5-alpha-reductase of the first and second types.

After taking Avodart, urination normalizes, the prostate gland size decreases, and the likelihood of curing the disease without surgery is increased.

Features of the medicine

According to specialists, Avodart tablets show therapeutic effect in 8-15 days after the beginning of treatment. The higher the dose of this drug, the more it affects the production of DHT.

Pharmacokinetic properties

The drug "Avodart", the price of which is indicated below, is found in the blood in the maximum concentration 1.5 hours after admission. Its bioavailability is 60%. Simultaneous food intake has no effect on the kinetic parameters of the drug.

This agent has a rather large degree of connection with plasma proteins (about 99%). It should also be noted that with a systematic and long-term intake of about 12% of the active ingredient enters the sperm.

How is the agent treated? What do the instructions and testimonials say about this? "Avodart" is extensively metabolized in the human body. Approximately 2-15% of the active substance is excreted unchanged through the intestine. Complete elimination of the drug is carried out about a month after the end of the course of therapy.

Experts say that even after six months, a small amount of medicine can be found in the blood.

Indications

What is the purpose of this drug? What do the instructions and reviews say about this? "Avodart" is a medicinal product that is used in the following cases:

• With monotherapy and prophylaxis of prostatic hyperplasia progression of the prostate (benign form) by reducing its size, improving urination, alleviating symptoms, and reducing the likelihood of surgery and the risk of acute urinary retention;
• With combined therapy with alpha1-adrenoblockers, as well as to prevent the progression of prostatic hyperplasia of the prostate (benign form) by reducing its size, improving urination, alleviating symptoms, reducing the likelihood of surgery and the risk of acute urinary retention.

Contraindications

It is forbidden to use Avodart when:

• Hypersensitivity to dutasteride, as well as other substances of the drug;
• Increased sensitivity to inhibitors of 5-alpha-reductase.

It should also be noted that this medication is contraindicated for admission to children and women.

With caution Avodart should be prescribed for hepatic insufficiency.

Avodart capsules: instructions for use

Medication is taken orally regardless of food intake.

Capsules are swallowed whole, not chewing and not opening (the contents can cause irritation of the mucous membrane of the oropharynx).

In BPH, adults and elderly men are prescribed a medicine in the amount of 1 capsule once a day.

Despite the fact that the therapeutic effect of taking this drug comes after two weeks, it is recommended to take at least six months.

For the treatment of the mentioned disease, Avodart can be used both in monotherapy and in combination with alpha 1-adrenoblockers.

Special medication

At a dose of 500 μg per day, about 0.1% of the drug is secreted by the kidneys. In this regard, there is no need to reduce dosage in people with disrupted urinary system.

Patients with impaired liver function Avodart should be taken with extreme caution, since its active substance undergoes intensive metabolism in this organ.

Adverse events

What side effects occur when taking this medication? What do doctors say about this? Avodart can cause the following undesirable reactions:

• Apathy and depression;
• Itching rashes on the skin, hives, swelling, allergic manifestations (up to the angioedema);
• Loss of hair on the surface of the body and hypertrichosis;
• Pain and testicular edema;
• Decreased libido and sexual desire, erectile dysfunction, swelling and painful sensations of the mammary glands, problems with ejaculation.

The likelihood of adverse reactions is significantly reduced with increasing duration of therapy (for example, from the second year of taking capsules).

If you combine Avodart with other medications, the frequency of occurrence, as well as the types of adverse events, may differ slightly.

Special Recommendations

Avodart capsules can not be opened, and also to allow contact of their contents with mucous membranes and skin integuments. If the drug is still on the skin, it should be washed off immediately with running water.

The combination of dutasteride and alpha-adrenoblockers increases the risk of heart disease.

Before taking the medication, as well as during the therapy, it is necessary to carry out the examination of the prostate gland (rectal finger, PSA, etc.).

The cost of capsules and the like

How much is Avodart? The price of this medicine is very high. You can buy 30 capsules of this medication for 1500-1600 rubles.

The most common analogues of Avodart are such products as Proscar, Adenosterid, Finpros, Urofin, Prostan, Penester, Finistera.

One can not help saying that the cost of these medicines may be slightly higher than the capsules we are considering.

Reviews

Avodart is a fairly popular drug that is used to treat and prevent BPH. Reviews about it can be found very different. Some patients report that after 12 months of use of the medication the prostate gland has significantly decreased. However, with the cessation of treatment, it again increased. Other patients are extremely unhappy with the high cost of this medication, as well as erectile dysfunction and a decrease in sexual desire while receiving it.

Experts argue that such reactions of the body disappear on their own after 3-4 months of treatment.