Antimicrobial drug Tsifran. Instructions for use

The drug "Cyphran" is an antimicrobial drug with a broad spectrum of action, which is part of the pharmacological group of fluoroquinolones. The active ingredients of this drug are ciprofloxacin and tinidazole. Due to the suppression of DNA gyrase and inhibition of the synthesis of bacterial DNA, these active substances are highly active to the majority of Gram-negative microorganisms.

In particular, the activity of the bactericidal action of the preparation "Tsifran" notes the use instructions for such bacteria: Neisseriagonorrhoeae, Neisseriameningitidis, Haemophilusinfluenzae, Pseudomonasaeruginosa, Salmonellaspp, Escherichiacoli and other microorganisms, strains producing and not producing penicillinase, as well as for methicillin-resistant strains And to Enterococcuspp, Chlamydiaspp, Mycobacteriumspp, Legionellaspp ... strains.

Pharmacological action of the bactericidal medicinal product of a wide spectrum of action "Tsifran" instruction for use is as follows: "This drug is intended for the treatment of infectious pathologies." Effective in the treatment of inflammatory processes - mixed infections, provoked by the activity of aerobic and anaerobic microorganisms and protozoa. "

Pharmacokinetics

The operating ingredients of the preparation "Cyfran" instructions for use call it well compatible. Both ciprofloxacin and tinidazole have good absorption in the digestive tract.

Considering each of the active substances of the drug, it should be noted that ciprofloxacin has approximately 70% bioavailability. Its absorption is somewhat slowed down when used concomitantly with food. This drug has a good penetrability in the tissues and body fluid, including bone, muscle, fat and cartilage. He penetrates into the organs of the urinary system, including in such an organ as the prostate. It is in the secret of her that a high concentration of the content of kiprofloxacin is found, as well as in sperm, saliva, bile, lymphatic fluid, mucus.

Tinidazole is 100% bioavailable. This component also quickly falls into high concentrations in tissues, the liquid medium of the human body, penetrating, in particular, into the cerebrospinal fluid, where it concentrates in the same degree as in plasma. About a quarter of the amount of ingested material is excreted in the urine in an unchanged state, about 10% is released as metabolites, and a very small part of the component leaves the body with feces.

Indications for the prescription of the drug "Tsifran" instruction for use calls the therapy of mixed-infection processes. Among the more specific pathologies for the treatment of which the drug in question is used, the following diseases can be distinguished:

• Osteomyelitis chronic ;

• Intra-abdominal infectious inflammatory processes;

• Amoebic dysentery, as well as mixed type dysentery (amoebic and bacterial);

• Periodontitis, periostitis and other infectious diseases of the oral cavity;

• Gynecological inflammatory pathologies;

• Chronic sinusitis;

• Infectious lesions of the skin, soft tissues;

• Postoperative infectious pathologies;

• Abscess of the lung.

Included in their number and other infections caused by aerobic and anaerobic bacteria, sensitive to the action of the components of the drug.

The preparation "Tsifran" is taken after a meal. You should drink tablets with water in sufficient quantities. Adult patients take the medicine twice a day on a tablet of 500 / 600mg or two 250 / 300mg. Patients under the age of eighteen years are not given this medication. It is not recommended for pregnant women.

Contraindications to the use of the described drug in therapy is hypersensitivity to the components that are part of the Cyphrane, as well as the pathology of the blood, porphyria.