Anti-inflammatory agent "Celebrex": instructions for use

Medication "Celebrex" instructions for use characterizes as a non-steroidal anti-inflammatory agent with pronounced antipyretic and analgesic properties. The effect of this drug is to suppress the synthesis of prostaglandins due to oppression of COX-2. At the same time, "Celebrex" tablets, the instruction for their use confirms this, to a much lesser degree than other non-steroidal anti-inflammatory drugs, contribute to the development of so-called gastroduodenal ulcers. As for the pharmacokinetics of this drug, its highest concentrations are noted one hundred and twenty minutes after use, and the half-life is about eight to twelve hours.

Take the tablets "Celebrex" instructions for use recommends in the complex therapy of diseases such as rheumatoid arthritis, spondylitis, algodismenorea and deforming osteoarthritis. In addition, this remedy is also prescribed for the purpose of arresting a pain syndrome caused by surgical interventions or traumas. According to the annotation, it can be used to treat patients diagnosed with familial adenomatous polyposis.

The main contraindications for the appointment of an anti-inflammatory drug such as Celebrex are individual intolerance to celecoxib, an allergic reaction to sulfonamides, and a condition after aorto-coronary bypass surgery. In addition, do not take this medication for people suffering from bronchial asthma, inflammatory bowel disease or heart failure.

In case of hypersensitivity to acetylsalicylic acid, do not start taking Celebrex tablets . The doctors' testimonies also testify to the undesirability of their use by people with severe form of renal or hepatic insufficiency. The list of contraindications includes the age of up to eighteen years, the period of gestation, lactation period, ischemic disease, gastrointestinal bleeding, peripheral arterial disease and peptic ulcer. With extreme caution to take the drug "Tselebreks" instruction for use advises in case of violations in the cardiovascular system, hyperlipidemia, dyslipidemia and diabetes. People with cerebrovascular diseases, physical diseases, peptic ulcer and predisposition to swelling and fluid retention should also refrain from using this anti-inflammatory drug.

The list of possible adverse reactions associated with taking Celebrex tablets includes tinnitus, thrombocytopenia, cardiac rhythm disturbance, alopecia, and hypertension. In addition, some patients complain of increased anxiety, coughing, upset of the stool, nausea, dysphagia, diarrhea and angioedema.