What is connective tissue dysplasia?

Dysplasia of connective tissue is a violation of the development of this body structure even at the embryo stage and in the early years of human life. The disorder is caused by mutations in certain genes that code for the synthesis of the substances necessary for their creation (collagen, elastin, proteoglycans, and so on) and manifests itself in the form of a change in the structure of fibrous tissues. In addition, in some cases, dysplasia may be due to a violation of the exchange of these substances, regardless of deviations from the norm in the genetic code. Thus, connective tissue dysplasia can occur at different levels, from the gene to the organism level in the form of a metabolic disorder.

To the genetic dysplasia belong those diseases that are not only inherited, but also have a pronounced clinical picture (for example, the Marfan syndrome).

But most often there is a so-called undifferentiated connective tissue dysplasia.

It is due to the complex effect on the fetus of a variety of factors that lead to a disruption in the synthesis and metabolism. Usually it is simply impossible to determine the true cause of this disease.

Such dysplasia of connective tissue manifests itself in the form of external and internal signs. External include articular, skin, bone-skeletal and minor developmental disorders.

Internal phenomena include such phenomena as connective tissue dysplasia of the heart, nervous system, respiratory organs, visual analyzer, abdominal organs.

The peculiarity of this disease is that it is either weak or does not manifest at all immediately after birth, even in cases when the form is clearly differentiated. Markers of dysplasia in a child begin to appear later and grow throughout life. The older a person becomes and the more unfavorable environmental factors affect him, the more pronounced dysplastic symptoms become.

A huge role in this play the so-called dizelementozy - a deficiency in the body of certain trace elements.

Magnesium is considered the main microelement, which contributes to the normal development of connective tissue.

The longer a person does not receive the required amount of magnesium, the more profound changes occur.

Dysplasia of connective tissue with a deficiency of magnesium is manifested in such a way that a large number of proteolytic enzymes begins to be produced.

The result is a significant softening of the collagen fibers. This leads to the fact that the connective tissue is even more degraded and, as a consequence, the symptoms of dysplasia are greatly enhanced.

Treatment of this disease is often based on the intake of drugs containing the necessary trace elements in the right proportions. And it is important not only the amount of substances coming with food, but also their ratio.