Urticaria Cholinergic: Causes, Symptoms, Folk and Medication

In the human body, along with other neurotransmitters that transmit impulses through the synaptic cleft between neurons, there is acetylcholine. He is responsible for the neuromuscular neuronal connection and is also the main one in the parasympathetic nervous system. In the event that for some reason this substance begins to be produced in excess, a person can develop a disease - cholinergic urticaria.

In the article we will talk about the reasons for its appearance and the methods of treatment.

General information about cholinergic urticaria

This ailment is rare. He accounts for no more than 8% of all cases of cases of urticaria. It is interesting that young people are most often affected by them, although there is no age or sex restriction for this disease.

On the skin, the urticaria of cholinergic resembles a burn from the leaves of the nettle - the same blisters or red itchy spots that cause severe discomfort. But in some cases the rash is imperceptible, however, the itch in this case of patients worries no less. In medicine, this disease has another name - itching dermatosis.

Cholinergic urticaria: pathogenesis

The reliable reasons for the appearance of the described pathology are still not known. None of the studies could convincingly prove the direct effect of a component on the appearance of its symptoms.

The generally accepted theory of the development of cholinergic urticaria so far associates allergy with the rupture of the so-called mast cells located in our skin. They are immune highly specialized units involved in adaptive immunity. And their break at a time when a person sweats from exposure to external heat, an increase in internal temperature or at the time of a stressful situation, is provoked by the release of acetylcholine.

Whether cholinergic urticaria has a cause other than those mentioned, it is not known, but in medicine there are 3 main factors that can cause it:

1. Pathological reaction to thermal effects.
2. Exercise stress.
3. Existing diseases (pathology of the endocrine system, gastrointestinal tract, as well as vegetative-vascular or neurocirculatory dystonia).

And the development of cholinergic urticaria begins only if a person has a predisposition to allergic reactions, and hypersensitivity to acetylcholine simultaneously.

Symptoms

Symptoms of the disease appear immediately after the impact of the irritating factor, and they are quite difficult to confuse with any other symptoms.

• The first appear small bubbles, the skin around which, as a rule, becomes edematic and hyperemic.
• Most often, a rash appears on the neck, in the neckline, forearms and chest. The lower part of the body is rarely involved.
• Vesicles strongly itch and cause burning.
• Cholinergic urticaria, the symptoms of which we are considering in this article, are often accompanied by an increase in temperature.
• Due to the fact that acetylcholine is a neurotransmitter, excessive sensitivity to it can cause manifestations of its excessive activity - diarrhea, nausea, vomiting, excessive salivation.

Diagnostics

The hysterectomy is easy to diagnose. To determine it, standard laboratory tests and anamnesis are sufficient. And due to the fact that the first manifestations of pathology are visible immediately after the provoking effect of any of the factors listed above, the patient can always quite clearly define what exactly caused the disease.

To clarify the diagnosis, a subcutaneous injection of an analog preparation of acetylcholine is carried out, or a provocative test is performed in the form of a thermal effect on the skin (for this, the patient's hand is placed in hot water). If after 20 minutes after this there are rashes that subsequently completely disappear, the diagnosis is considered proven.

Cholinergic urticaria: treatment with folk remedies

If other forms of the disease can be treated with antihistamine drugs, the cholinergic urticaria proves to be quite resistant to them.

In this case, these drugs can only slightly and for a short time reduce the symptoms of allergies. Researchers attribute this to the hypersensitivity of the human body to the irritant, which he himself produces.

Several more effective may be 2 and 3 generations of histamine receptor blockers - Loratadine, Cetirizine, Ebastin, etc. They should be prescribed only by an experienced dermatologist, selecting an individual dosage and taking into account possible side effects.

In some cases, folk remedies may also prove useful:

1. Infusion of licorice root, which should drink half the glass twice a day. Powder from this root is taken for ½ tsp. And washed down with water.
2. Infusion of dry nettle. The grass is poured over with boiling water and allowed to stand. Drink like tea 3 times a day.
3. No less useful are mint and chamomile teas, which have a mild soothing effect. They are drunk instead of black tea.
4. They also take horseradish juice (root), which is mixed with honey in a ratio of 1: 1. Take a teaspoon three times a day.

To eliminate the itching and swelling, you can make lotions from a solution of soda, chamomile, string, lemon juice, diluted with water. Any of these means impregnate a sterile bandage and apply for half an hour to areas with a rash. This procedure, if repeated four times a day, can alleviate the condition of the patient.

Prevention of an allergic reaction

If the patient has once been diagnosed as having a "cholinergic urticaria", then in order to avoid relapse of the disease, he will need to adhere to certain rules and restrictions:

• Avoid using a hot bath. For washing now it is more useful to take a cool shower.
• From the diet will have to exclude spicy dishes. Hot food can also cause harm.
• Inadmissible alcohol.
• It will be necessary to avoid profuse sweating both during physical exertion and in all other cases. When sweat appears, you need to rest in the shade or take a shower.
• Care should be taken to avoid stressful situations. When this is not possible, the patient must take a sedative.